Polymorphisms in DSSP (rs36094464) and RUNX2 (rs566712) Genes Contribute to the Susceptibility of Dental Caries in Childhood

SUMMARY: Dental caries corresponds to an ecological and non-contagious, dynamic and chronic disease of multifactorial origin; currently there is evidence of how genetic factors could be included as predisposing agents to suffer it, however this evidence is diverse and incipient. a cross-sectional st...

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Autores principales:	Sanhueza,Jorge, Bustos,Luis, Rodríguez,Nelia, Borie-Echeverria,Evelyn, Salinas,Paulo
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2021
Materias:	Caries Childhood Polymorphisms DSPP RUNX2
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000300802
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spelling	oai:scielo:S0717-950220210003008022021-07-25Polymorphisms in DSSP (rs36094464) and RUNX2 (rs566712) Genes Contribute to the Susceptibility of Dental Caries in ChildhoodSanhueza,JorgeBustos,LuisRodríguez,NeliaBorie-Echeverria,EvelynSalinas,Paulo Caries Childhood Polymorphisms DSPP RUNX2 SUMMARY: Dental caries corresponds to an ecological and non-contagious, dynamic and chronic disease of multifactorial origin; currently there is evidence of how genetic factors could be included as predisposing agents to suffer it, however this evidence is diverse and incipient. a cross-sectional study was p erformed to investigate the possible associations of DSPP (rs36094464), RUNX2 (rs566712) and KLK4 (rs198968) polymorphisms in early childhood caries. Saliva samples of children (2-11years old) were collected and genotyped for DSPP (rs36094464), RUNX2 (rs566712) and KLK4 (rs198968) polymorphisms. Through the ceft index their caries history was determined and the gene variants were students through molecular biology techniques. polymorphisms of the DSSP (rs36094464) and RUNX2 (rs566712) are associated and contribute to the susceptibility of dental caries disease in early childhood, as they are related to their history of caries. KLK4 (rs198968) polymorphisms are not associated. In conclusions, the studied polymorphisms on DSSP and RUNX2 genes are associated with changes in the tooth microarchitecture, favoring the appearance of microlesions that would contribute to dental caries disease susceptibility in early childhood. Also, no association was found for the studied polymorphism of the KLK4 gene with dental caries disease susceptibility.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.39 n.3 20212021-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000300802en10.4067/S0717-95022021000300802
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Caries Childhood Polymorphisms DSPP RUNX2
spellingShingle	Caries Childhood Polymorphisms DSPP RUNX2 Sanhueza,Jorge Bustos,Luis Rodríguez,Nelia Borie-Echeverria,Evelyn Salinas,Paulo Polymorphisms in DSSP (rs36094464) and RUNX2 (rs566712) Genes Contribute to the Susceptibility of Dental Caries in Childhood
description	SUMMARY: Dental caries corresponds to an ecological and non-contagious, dynamic and chronic disease of multifactorial origin; currently there is evidence of how genetic factors could be included as predisposing agents to suffer it, however this evidence is diverse and incipient. a cross-sectional study was p erformed to investigate the possible associations of DSPP (rs36094464), RUNX2 (rs566712) and KLK4 (rs198968) polymorphisms in early childhood caries. Saliva samples of children (2-11years old) were collected and genotyped for DSPP (rs36094464), RUNX2 (rs566712) and KLK4 (rs198968) polymorphisms. Through the ceft index their caries history was determined and the gene variants were students through molecular biology techniques. polymorphisms of the DSSP (rs36094464) and RUNX2 (rs566712) are associated and contribute to the susceptibility of dental caries disease in early childhood, as they are related to their history of caries. KLK4 (rs198968) polymorphisms are not associated. In conclusions, the studied polymorphisms on DSSP and RUNX2 genes are associated with changes in the tooth microarchitecture, favoring the appearance of microlesions that would contribute to dental caries disease susceptibility in early childhood. Also, no association was found for the studied polymorphism of the KLK4 gene with dental caries disease susceptibility.
author	Sanhueza,Jorge Bustos,Luis Rodríguez,Nelia Borie-Echeverria,Evelyn Salinas,Paulo
author_facet	Sanhueza,Jorge Bustos,Luis Rodríguez,Nelia Borie-Echeverria,Evelyn Salinas,Paulo
author_sort	Sanhueza,Jorge
title	Polymorphisms in DSSP (rs36094464) and RUNX2 (rs566712) Genes Contribute to the Susceptibility of Dental Caries in Childhood
title_short	Polymorphisms in DSSP (rs36094464) and RUNX2 (rs566712) Genes Contribute to the Susceptibility of Dental Caries in Childhood
title_full	Polymorphisms in DSSP (rs36094464) and RUNX2 (rs566712) Genes Contribute to the Susceptibility of Dental Caries in Childhood
title_fullStr	Polymorphisms in DSSP (rs36094464) and RUNX2 (rs566712) Genes Contribute to the Susceptibility of Dental Caries in Childhood
title_full_unstemmed	Polymorphisms in DSSP (rs36094464) and RUNX2 (rs566712) Genes Contribute to the Susceptibility of Dental Caries in Childhood
title_sort	polymorphisms in dssp (rs36094464) and runx2 (rs566712) genes contribute to the susceptibility of dental caries in childhood
publisher	Sociedad Chilena de Anatomía
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000300802
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Polymorphisms in DSSP (rs36094464) and RUNX2 (rs566712) Genes Contribute to the Susceptibility of Dental Caries in Childhood

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