Effects of Acute Oral Exposure to Acrylamide on Histological Structures of the Stomach in Wistar Rats

SUMMARY: Acrylamide is a toxic chemical substance with wide implementation in chemical industry. In 2002 the presence of acrylamide was discovered in foods rich in starch which are prepared at high temperatures. The aim of this study was to investigate the histopathological changes in the gastric ti...

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Auteurs principaux:	Sabo,I. J. R, Lakic,Tanja Z, Capo,Ivan D, Andrejic-Visnjic,Bojana M, Matavulj,Milica, Djolai,Matilda A
Langue:	English
Publié:	Sociedad Chilena de Anatomía 2021
Sujets:	Acrylamide Food Stomach Wistar Rat Toxicity
Accès en ligne:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000400963
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spelling	oai:scielo:S0717-950220210004009632021-08-16Effects of Acute Oral Exposure to Acrylamide on Histological Structures of the Stomach in Wistar RatsSabo,I. J. RLakic,Tanja ZCapo,Ivan DAndrejic-Visnjic,Bojana MMatavulj,MilicaDjolai,Matilda A Acrylamide Food Stomach Wistar Rat Toxicity SUMMARY: Acrylamide is a toxic chemical substance with wide implementation in chemical industry. In 2002 the presence of acrylamide was discovered in foods rich in starch which are prepared at high temperatures. The aim of this study was to investigate the histopathological changes in the gastric tissue in Wistar rats induced with injection of oral acrylamide. The research was carried out 6 groups of 5 animals (Wistar rats), two control groups and four experimental groups. Histological changes in the stomach tissue of Wistar rats are seen as a direct slight damage of the surface epithelium, accompanynig inflammatory reaction and renewal of the epithelium. Examined inflammatory and degenerative parameters show a positive correlation with respect to dose and time of exposition to acrylamide. Knowing the mechanism of action of these toxic substances, allows to apply adequate prevention in nutrition and make an appropriate choice of therapeutic methods.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.39 n.4 20212021-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000400963en10.4067/S0717-95022021000400963
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Acrylamide Food Stomach Wistar Rat Toxicity
spellingShingle	Acrylamide Food Stomach Wistar Rat Toxicity Sabo,I. J. R Lakic,Tanja Z Capo,Ivan D Andrejic-Visnjic,Bojana M Matavulj,Milica Djolai,Matilda A Effects of Acute Oral Exposure to Acrylamide on Histological Structures of the Stomach in Wistar Rats
description	SUMMARY: Acrylamide is a toxic chemical substance with wide implementation in chemical industry. In 2002 the presence of acrylamide was discovered in foods rich in starch which are prepared at high temperatures. The aim of this study was to investigate the histopathological changes in the gastric tissue in Wistar rats induced with injection of oral acrylamide. The research was carried out 6 groups of 5 animals (Wistar rats), two control groups and four experimental groups. Histological changes in the stomach tissue of Wistar rats are seen as a direct slight damage of the surface epithelium, accompanynig inflammatory reaction and renewal of the epithelium. Examined inflammatory and degenerative parameters show a positive correlation with respect to dose and time of exposition to acrylamide. Knowing the mechanism of action of these toxic substances, allows to apply adequate prevention in nutrition and make an appropriate choice of therapeutic methods.
author	Sabo,I. J. R Lakic,Tanja Z Capo,Ivan D Andrejic-Visnjic,Bojana M Matavulj,Milica Djolai,Matilda A
author_facet	Sabo,I. J. R Lakic,Tanja Z Capo,Ivan D Andrejic-Visnjic,Bojana M Matavulj,Milica Djolai,Matilda A
author_sort	Sabo,I. J. R
title	Effects of Acute Oral Exposure to Acrylamide on Histological Structures of the Stomach in Wistar Rats
title_short	Effects of Acute Oral Exposure to Acrylamide on Histological Structures of the Stomach in Wistar Rats
title_full	Effects of Acute Oral Exposure to Acrylamide on Histological Structures of the Stomach in Wistar Rats
title_fullStr	Effects of Acute Oral Exposure to Acrylamide on Histological Structures of the Stomach in Wistar Rats
title_full_unstemmed	Effects of Acute Oral Exposure to Acrylamide on Histological Structures of the Stomach in Wistar Rats
title_sort	effects of acute oral exposure to acrylamide on histological structures of the stomach in wistar rats
publisher	Sociedad Chilena de Anatomía
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000400963
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Effects of Acute Oral Exposure to Acrylamide on Histological Structures of the Stomach in Wistar Rats

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