Correlation Between COVID-19 Severity, Body Mass Index and Radiological Hepatic Morphology

SUMMARY: Obesity and fatty liver steatosis are already considered metabolic risk factors which may aggravate the severity of COVID-19. This study aims to investigate the correlation between COVID-19 severity, obesity, and liver steatosis and fibrosis. 230 consecutive patients with laboratory-confirm...

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Autores principales:	Qandeel,Haitham, Tayyem,Raed, Fataftah,Jehad, Qasem,Muhannad, Sami,Rawan, Ashour,Haneen, Hasanat,Subreen, Tayyem,Rand, Alqassieh,Rami
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2021
Materias:	COVID-1 Obesity Fatty liver Body Mass Index Hepatic Steatosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000401096
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spelling	oai:scielo:S0717-950220210004010962021-08-16Correlation Between COVID-19 Severity, Body Mass Index and Radiological Hepatic MorphologyQandeel,HaithamTayyem,RaedFataftah,JehadQasem,MuhannadSami,RawanAshour,HaneenHasanat,SubreenTayyem,RandAlqassieh,Rami COVID-1 Obesity Fatty liver Body Mass Index Hepatic Steatosis SUMMARY: Obesity and fatty liver steatosis are already considered metabolic risk factors which may aggravate the severity of COVID-19. This study aims to investigate the correlation between COVID-19 severity, obesity, and liver steatosis and fibrosis. 230 consecutive patients with laboratory-confirmed COVID-19 aged between 15 and 84? years, admitted to a hospital devoted to COVID-19 patients, were enrolled in the study. COVID-19 severity was classified as severe versus non-severe based on admission to ICU. Obesity was assessed by Body Mass Index (BMI). CT-scan was used to check for the liver steatosis. Fibrosis-4 score was calculated. The study was conducted in March-May 2020. Obesity strongly and positively correlated with severe COVID-19 illness r: 0.760 (P<0.001). Hepatic steatosis had rather less of a correlation with COVID-19 severity r: 0.365 (P<0.001). Multivariable-adjusted association between hepatic steatosis or obesity, or both (as exposure) and COVID-19 severity (as the outcome) revealed increased risk of severe COVID-19 illness with obesity (Adjusted model I OR: 465.3, 95 % CI: 21.9-9873.3, P<0.001), with hepatic steatosis (Adjusted model I OR: 5.1, 95 % CI: 1.2-21.0, P<0.025), and with hepatic steatosis among obese patients (Adjusted model I OR: 132, 95 % CI: 10.3-1691.8, P<0.001). Obesity remained the most noticeable factor that strongly correlated with COVID-19 severity, more than liver steatosis. However, the risk to COVID-19 severity was greater in those with both factors: obesity and liver steatosis.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.39 n.4 20212021-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000401096en10.4067/S0717-95022021000401096
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	COVID-1 Obesity Fatty liver Body Mass Index Hepatic Steatosis
spellingShingle	COVID-1 Obesity Fatty liver Body Mass Index Hepatic Steatosis Qandeel,Haitham Tayyem,Raed Fataftah,Jehad Qasem,Muhannad Sami,Rawan Ashour,Haneen Hasanat,Subreen Tayyem,Rand Alqassieh,Rami Correlation Between COVID-19 Severity, Body Mass Index and Radiological Hepatic Morphology
description	SUMMARY: Obesity and fatty liver steatosis are already considered metabolic risk factors which may aggravate the severity of COVID-19. This study aims to investigate the correlation between COVID-19 severity, obesity, and liver steatosis and fibrosis. 230 consecutive patients with laboratory-confirmed COVID-19 aged between 15 and 84? years, admitted to a hospital devoted to COVID-19 patients, were enrolled in the study. COVID-19 severity was classified as severe versus non-severe based on admission to ICU. Obesity was assessed by Body Mass Index (BMI). CT-scan was used to check for the liver steatosis. Fibrosis-4 score was calculated. The study was conducted in March-May 2020. Obesity strongly and positively correlated with severe COVID-19 illness r: 0.760 (P<0.001). Hepatic steatosis had rather less of a correlation with COVID-19 severity r: 0.365 (P<0.001). Multivariable-adjusted association between hepatic steatosis or obesity, or both (as exposure) and COVID-19 severity (as the outcome) revealed increased risk of severe COVID-19 illness with obesity (Adjusted model I OR: 465.3, 95 % CI: 21.9-9873.3, P<0.001), with hepatic steatosis (Adjusted model I OR: 5.1, 95 % CI: 1.2-21.0, P<0.025), and with hepatic steatosis among obese patients (Adjusted model I OR: 132, 95 % CI: 10.3-1691.8, P<0.001). Obesity remained the most noticeable factor that strongly correlated with COVID-19 severity, more than liver steatosis. However, the risk to COVID-19 severity was greater in those with both factors: obesity and liver steatosis.
author	Qandeel,Haitham Tayyem,Raed Fataftah,Jehad Qasem,Muhannad Sami,Rawan Ashour,Haneen Hasanat,Subreen Tayyem,Rand Alqassieh,Rami
author_facet	Qandeel,Haitham Tayyem,Raed Fataftah,Jehad Qasem,Muhannad Sami,Rawan Ashour,Haneen Hasanat,Subreen Tayyem,Rand Alqassieh,Rami
author_sort	Qandeel,Haitham
title	Correlation Between COVID-19 Severity, Body Mass Index and Radiological Hepatic Morphology
title_short	Correlation Between COVID-19 Severity, Body Mass Index and Radiological Hepatic Morphology
title_full	Correlation Between COVID-19 Severity, Body Mass Index and Radiological Hepatic Morphology
title_fullStr	Correlation Between COVID-19 Severity, Body Mass Index and Radiological Hepatic Morphology
title_full_unstemmed	Correlation Between COVID-19 Severity, Body Mass Index and Radiological Hepatic Morphology
title_sort	correlation between covid-19 severity, body mass index and radiological hepatic morphology
publisher	Sociedad Chilena de Anatomía
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000401096
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Correlation Between COVID-19 Severity, Body Mass Index and Radiological Hepatic Morphology

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