Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review

SUMMARY: The cause and prevention of recurrent aphthous stomatitis (also called aphthous ulcers or canker sores) are still unknown. This may be due in part to ignorance of the risk factors present in susceptible people. In this systematic review (PROSPERO record #CRD42019122214), we show that most o...

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Autores principales:	Rivera,César, Muñoz,Antonieta, Puentes,Carolina, Aguayo,Esteban
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2021
Materias:	Aphthous stomatitis Risk factors Genetic polymorphisms Multivariate analysis Systematic review.
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000401102
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spelling	oai:scielo:S0717-950220210004011022021-08-16Risk Factors for Recurrent Aphthous Stomatitis: A Systematic ReviewRivera,CésarMuñoz,AntonietaPuentes,CarolinaAguayo,Esteban Aphthous stomatitis Risk factors Genetic polymorphisms Multivariate analysis Systematic review. SUMMARY: The cause and prevention of recurrent aphthous stomatitis (also called aphthous ulcers or canker sores) are still unknown. This may be due in part to ignorance of the risk factors present in susceptible people. In this systematic review (PROSPERO record #CRD42019122214), we show that most of the risk factors for the disease are single nucleotide genetic polymorphisms in genes related to the functioning of immune system (TLR4, MMP9, E-selectin, IL-1 beta and TNF-alpha). Single nucleotide genetic polymorphisms do not constitute a modifiable risk. This indicates that, at least in part, susceptibility to recurrent aphthous stomatitis is hereditary, and that these factors cannot be modified.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.39 n.4 20212021-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000401102en10.4067/S0717-95022021000401102
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Aphthous stomatitis Risk factors Genetic polymorphisms Multivariate analysis Systematic review.
spellingShingle	Aphthous stomatitis Risk factors Genetic polymorphisms Multivariate analysis Systematic review. Rivera,César Muñoz,Antonieta Puentes,Carolina Aguayo,Esteban Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review
description	SUMMARY: The cause and prevention of recurrent aphthous stomatitis (also called aphthous ulcers or canker sores) are still unknown. This may be due in part to ignorance of the risk factors present in susceptible people. In this systematic review (PROSPERO record #CRD42019122214), we show that most of the risk factors for the disease are single nucleotide genetic polymorphisms in genes related to the functioning of immune system (TLR4, MMP9, E-selectin, IL-1 beta and TNF-alpha). Single nucleotide genetic polymorphisms do not constitute a modifiable risk. This indicates that, at least in part, susceptibility to recurrent aphthous stomatitis is hereditary, and that these factors cannot be modified.
author	Rivera,César Muñoz,Antonieta Puentes,Carolina Aguayo,Esteban
author_facet	Rivera,César Muñoz,Antonieta Puentes,Carolina Aguayo,Esteban
author_sort	Rivera,César
title	Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review
title_short	Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review
title_full	Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review
title_fullStr	Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review
title_full_unstemmed	Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review
title_sort	risk factors for recurrent aphthous stomatitis: a systematic review
publisher	Sociedad Chilena de Anatomía
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000401102
work_keys_str_mv	AT riveracesar riskfactorsforrecurrentaphthousstomatitisasystematicreview AT munozantonieta riskfactorsforrecurrentaphthousstomatitisasystematicreview AT puentescarolina riskfactorsforrecurrentaphthousstomatitisasystematicreview AT aguayoesteban riskfactorsforrecurrentaphthousstomatitisasystematicreview
_version_	1718445208840962048

Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review

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