Scar-Free Wound Healing Following Full-Thickness Cutaneous Wounding in the Tail and Body of Scincella tsinlingensis

SUMMARY: The cutaneous wounds of trunk and tail healing scar-free or with scar were different in lizard species. Full- thickness cutaneous injuries of tail and body of Scincella tsinlingensis were examined by histomorphological and immunohistochemistrical methods. The results showed that all injurie...

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Autores principales:	Yang,Chun, Wang,Xin, Zhang,Huihui, Li,Lin
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2021
Materias:	Scincella tsinlingensis Skin wound healing Histology Immunohistochemistry
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000401139
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spelling	oai:scielo:S0717-950220210004011392021-08-16Scar-Free Wound Healing Following Full-Thickness Cutaneous Wounding in the Tail and Body of Scincella tsinlingensisYang,ChunWang,XinZhang,HuihuiLi,Lin Scincella tsinlingensis Skin wound healing Histology Immunohistochemistry SUMMARY: The cutaneous wounds of trunk and tail healing scar-free or with scar were different in lizard species. Full- thickness cutaneous injuries of tail and body of Scincella tsinlingensis were examined by histomorphological and immunohistochemistrical methods. The results showed that all injuries healed without scarring. The process of the wound healing of S. tsinlingensis involved hemostasis, re-epithelialization, proliferation and remodelling, which also could be further subdivided into six stages. Stage I, 0-2 day post wound (dpw), the blood oozed gradually, no obvious wound contraction, minimal blood loss. Stage II, 2-10 dpw, the wound bed covered by the fibrin clot of blood, tissue fluid and tissue debris. Stage III, 7d-15 dpw, the wrinkled wound epitheliums was gradually stratified, and its surface was keratinized and exfoliated. Stage IV, 10-28 dpw, pigment cells were distributed at the boundary between epidermis and dermis, with few blood vessels and no granulation tissue formation. Stage V, 20-70 dpw, opaque scales covered the wound epithelium with randomly scattered melanophores in the base of the epidermis. Stage VI, 45-135 dpw, the epidermis and dermis restored to the thickness of the original skin. Regenerated scales were similar to scales of the uninjured dermis. The positive immunostaining of matrix metalloproteinases-9, cytokeratin 6, alpha smooth muscle actin, caspase 3 and transforming growth factor-β3 showed the specificity of healing period and different stages, which participated in skin wounds healing of S. tsinlingensis.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.39 n.4 20212021-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000401139en10.4067/S0717-95022021000401139
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Scincella tsinlingensis Skin wound healing Histology Immunohistochemistry
spellingShingle	Scincella tsinlingensis Skin wound healing Histology Immunohistochemistry Yang,Chun Wang,Xin Zhang,Huihui Li,Lin Scar-Free Wound Healing Following Full-Thickness Cutaneous Wounding in the Tail and Body of Scincella tsinlingensis
description	SUMMARY: The cutaneous wounds of trunk and tail healing scar-free or with scar were different in lizard species. Full- thickness cutaneous injuries of tail and body of Scincella tsinlingensis were examined by histomorphological and immunohistochemistrical methods. The results showed that all injuries healed without scarring. The process of the wound healing of S. tsinlingensis involved hemostasis, re-epithelialization, proliferation and remodelling, which also could be further subdivided into six stages. Stage I, 0-2 day post wound (dpw), the blood oozed gradually, no obvious wound contraction, minimal blood loss. Stage II, 2-10 dpw, the wound bed covered by the fibrin clot of blood, tissue fluid and tissue debris. Stage III, 7d-15 dpw, the wrinkled wound epitheliums was gradually stratified, and its surface was keratinized and exfoliated. Stage IV, 10-28 dpw, pigment cells were distributed at the boundary between epidermis and dermis, with few blood vessels and no granulation tissue formation. Stage V, 20-70 dpw, opaque scales covered the wound epithelium with randomly scattered melanophores in the base of the epidermis. Stage VI, 45-135 dpw, the epidermis and dermis restored to the thickness of the original skin. Regenerated scales were similar to scales of the uninjured dermis. The positive immunostaining of matrix metalloproteinases-9, cytokeratin 6, alpha smooth muscle actin, caspase 3 and transforming growth factor-β3 showed the specificity of healing period and different stages, which participated in skin wounds healing of S. tsinlingensis.
author	Yang,Chun Wang,Xin Zhang,Huihui Li,Lin
author_facet	Yang,Chun Wang,Xin Zhang,Huihui Li,Lin
author_sort	Yang,Chun
title	Scar-Free Wound Healing Following Full-Thickness Cutaneous Wounding in the Tail and Body of Scincella tsinlingensis
title_short	Scar-Free Wound Healing Following Full-Thickness Cutaneous Wounding in the Tail and Body of Scincella tsinlingensis
title_full	Scar-Free Wound Healing Following Full-Thickness Cutaneous Wounding in the Tail and Body of Scincella tsinlingensis
title_fullStr	Scar-Free Wound Healing Following Full-Thickness Cutaneous Wounding in the Tail and Body of Scincella tsinlingensis
title_full_unstemmed	Scar-Free Wound Healing Following Full-Thickness Cutaneous Wounding in the Tail and Body of Scincella tsinlingensis
title_sort	scar-free wound healing following full-thickness cutaneous wounding in the tail and body of scincella tsinlingensis
publisher	Sociedad Chilena de Anatomía
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000401139
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Scar-Free Wound Healing Following Full-Thickness Cutaneous Wounding in the Tail and Body of Scincella tsinlingensis

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