Expression of Myosin Heavy Chain Isoform mRNA Transcripts in the Masseter and Medial Pterygoid Muscles

SUMMARY: Both the masseter and medial pterygoid muscles elevate the mandible, raising the lower jaw by acting simultaneously on the lateral and medial surfaces of the mandibular ramus. Nevertheless, electromyographic studies indicate that these muscles, as well as the superficial and deep heads of t...

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Autores principales:	Ciurana,Neus, Artells,Rosa, Casado,Aroa, Potau,Josep Maria
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2021
Materias:	Masseter Medial pterygoid Myosin heavy chain
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000501406
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spelling	oai:scielo:S0717-950220210005014062021-10-19Expression of Myosin Heavy Chain Isoform mRNA Transcripts in the Masseter and Medial Pterygoid MusclesCiurana,NeusArtells,RosaCasado,AroaPotau,Josep Maria Masseter Medial pterygoid Myosin heavy chain SUMMARY: Both the masseter and medial pterygoid muscles elevate the mandible, raising the lower jaw by acting simultaneously on the lateral and medial surfaces of the mandibular ramus. Nevertheless, electromyographic studies indicate that these muscles, as well as the superficial and deep heads of the masseter, act in a different way during mastication. We have analyzed by real time quantitative polymerase chain reaction (RT-qPCR) the expression of myosin heavy chain (MHC) isoforms in the masseter and medial pterygoid muscles in humans in order to identify possible differences in the expression patterns that may be related to functional differences identified with electromyography. Our findings indicate that the expression pattern of MHC isoforms in the two muscles is characteristic of fast and powerful phasic muscles. We have also observed a high percentage of expression of the MHC-IIx isoform and the expression of the MHC-M isoform at the mRNA level in both muscles, an isoform that does not translate into protein in the masticatory muscles of humans. The high percentage of expression of the MHC-IIx isoform in humans can be related to a high contractile speed of the masseter and medial pterygoid in humans. On the other hand, the low percentage of expression of the MHC-M isoform at the mRNA level in both muscles can be related to the complex evolutionary process that has reduced the size and force of the masticatory muscles in humans.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.39 n.5 20212021-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000501406en10.4067/S0717-95022021000501406
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Masseter Medial pterygoid Myosin heavy chain
spellingShingle	Masseter Medial pterygoid Myosin heavy chain Ciurana,Neus Artells,Rosa Casado,Aroa Potau,Josep Maria Expression of Myosin Heavy Chain Isoform mRNA Transcripts in the Masseter and Medial Pterygoid Muscles
description	SUMMARY: Both the masseter and medial pterygoid muscles elevate the mandible, raising the lower jaw by acting simultaneously on the lateral and medial surfaces of the mandibular ramus. Nevertheless, electromyographic studies indicate that these muscles, as well as the superficial and deep heads of the masseter, act in a different way during mastication. We have analyzed by real time quantitative polymerase chain reaction (RT-qPCR) the expression of myosin heavy chain (MHC) isoforms in the masseter and medial pterygoid muscles in humans in order to identify possible differences in the expression patterns that may be related to functional differences identified with electromyography. Our findings indicate that the expression pattern of MHC isoforms in the two muscles is characteristic of fast and powerful phasic muscles. We have also observed a high percentage of expression of the MHC-IIx isoform and the expression of the MHC-M isoform at the mRNA level in both muscles, an isoform that does not translate into protein in the masticatory muscles of humans. The high percentage of expression of the MHC-IIx isoform in humans can be related to a high contractile speed of the masseter and medial pterygoid in humans. On the other hand, the low percentage of expression of the MHC-M isoform at the mRNA level in both muscles can be related to the complex evolutionary process that has reduced the size and force of the masticatory muscles in humans.
author	Ciurana,Neus Artells,Rosa Casado,Aroa Potau,Josep Maria
author_facet	Ciurana,Neus Artells,Rosa Casado,Aroa Potau,Josep Maria
author_sort	Ciurana,Neus
title	Expression of Myosin Heavy Chain Isoform mRNA Transcripts in the Masseter and Medial Pterygoid Muscles
title_short	Expression of Myosin Heavy Chain Isoform mRNA Transcripts in the Masseter and Medial Pterygoid Muscles
title_full	Expression of Myosin Heavy Chain Isoform mRNA Transcripts in the Masseter and Medial Pterygoid Muscles
title_fullStr	Expression of Myosin Heavy Chain Isoform mRNA Transcripts in the Masseter and Medial Pterygoid Muscles
title_full_unstemmed	Expression of Myosin Heavy Chain Isoform mRNA Transcripts in the Masseter and Medial Pterygoid Muscles
title_sort	expression of myosin heavy chain isoform mrna transcripts in the masseter and medial pterygoid muscles
publisher	Sociedad Chilena de Anatomía
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000501406
work_keys_str_mv	AT ciurananeus expressionofmyosinheavychainisoformmrnatranscriptsinthemasseterandmedialpterygoidmuscles AT artellsrosa expressionofmyosinheavychainisoformmrnatranscriptsinthemasseterandmedialpterygoidmuscles AT casadoaroa expressionofmyosinheavychainisoformmrnatranscriptsinthemasseterandmedialpterygoidmuscles AT potaujosepmaria expressionofmyosinheavychainisoformmrnatranscriptsinthemasseterandmedialpterygoidmuscles
_version_	1718445217086963712

Expression of Myosin Heavy Chain Isoform mRNA Transcripts in the Masseter and Medial Pterygoid Muscles

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