Effects of Exogenous Ghrelin on the Tissue Structure and Somato-Statin Secretion in the Pancreas of African Ostrich Chicks

SUMMARY: This study aimed to investigate the effect of exogenous ghrelin on pancreatic growth and development in African ostrich chicks. Sixteen 40-day-old African ostrich chicks (male or female) were randomly divided into four groups and injected intravenously metatarsal vein with saline (control)...

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Autores principales:	Li,Baitao, Li,Peng, Wang,Jiaxiang, Liu,Siyu, Ye,Lixun, Pi,Jinsong, Peng,Kemei, Sun,Qing
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2021
Materias:	African ostrich Ghrelin Pancreas Growth and development
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000501459
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spelling	oai:scielo:S0717-950220210005014592021-10-19Effects of Exogenous Ghrelin on the Tissue Structure and Somato-Statin Secretion in the Pancreas of African Ostrich ChicksLi,BaitaoLi,PengWang,JiaxiangLiu,SiyuYe,LixunPi,JinsongPeng,KemeiSun,Qing African ostrich Ghrelin Pancreas Growth and development SUMMARY: This study aimed to investigate the effect of exogenous ghrelin on pancreatic growth and development in African ostrich chicks. Sixteen 40-day-old African ostrich chicks (male or female) were randomly divided into four groups and injected intravenously metatarsal vein with saline (control) or ghrelin (10, 50, and 100 μg/kg) for 6 days. Body and pancreas weight were determined, structural characteristics were observed using HE staining, somatostatin-immunopositive cells were detected using immunohistochemistry. The results were as follows: 1. The 50 and 100 μg/kg groups showed lower relative pancreas weight than the control group (P < 0.05). 2.The islet area per unit area of the pancreas was higher in the 10, 50, and 100 μg/kg groups than in the control group (P < 0.05). The number of islets per unit area of the pancreas was lower in the 10 μg/kg group than in the control (P < 0.05) and slightly higher in the 50 and 100 μg/kg groups than in the control (P > 0.05. Moreover, compared with the control, the islet cells in treatment groups were loosely arranged and showed reduced cytoplasm. In the exocrine pancreas, the volume of acinar cells in the 10, 50, and 100 μg/kg groups all decreased to varying degrees. 3. Somatostatin immunopositive cells were mainly located around the periphery of the islets and sporadically distributed in the center. The density of the somatostatin immunopositive cells in the 10, 50, and 100 μg/kg groups was higher than that in the control (P < 0.05). These findings suggest that exogenous ghrelin increases the area and number of islets and number of somatostatin immunopositive cells but reduces relative pancreas weight and effects the morphological and structural development of the pancreas, which may inhibit the pancreatic growth and development in African ostrich chicks.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.39 n.5 20212021-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000501459en10.4067/S0717-95022021000501459
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	African ostrich Ghrelin Pancreas Growth and development
spellingShingle	African ostrich Ghrelin Pancreas Growth and development Li,Baitao Li,Peng Wang,Jiaxiang Liu,Siyu Ye,Lixun Pi,Jinsong Peng,Kemei Sun,Qing Effects of Exogenous Ghrelin on the Tissue Structure and Somato-Statin Secretion in the Pancreas of African Ostrich Chicks
description	SUMMARY: This study aimed to investigate the effect of exogenous ghrelin on pancreatic growth and development in African ostrich chicks. Sixteen 40-day-old African ostrich chicks (male or female) were randomly divided into four groups and injected intravenously metatarsal vein with saline (control) or ghrelin (10, 50, and 100 μg/kg) for 6 days. Body and pancreas weight were determined, structural characteristics were observed using HE staining, somatostatin-immunopositive cells were detected using immunohistochemistry. The results were as follows: 1. The 50 and 100 μg/kg groups showed lower relative pancreas weight than the control group (P < 0.05). 2.The islet area per unit area of the pancreas was higher in the 10, 50, and 100 μg/kg groups than in the control group (P < 0.05). The number of islets per unit area of the pancreas was lower in the 10 μg/kg group than in the control (P < 0.05) and slightly higher in the 50 and 100 μg/kg groups than in the control (P > 0.05. Moreover, compared with the control, the islet cells in treatment groups were loosely arranged and showed reduced cytoplasm. In the exocrine pancreas, the volume of acinar cells in the 10, 50, and 100 μg/kg groups all decreased to varying degrees. 3. Somatostatin immunopositive cells were mainly located around the periphery of the islets and sporadically distributed in the center. The density of the somatostatin immunopositive cells in the 10, 50, and 100 μg/kg groups was higher than that in the control (P < 0.05). These findings suggest that exogenous ghrelin increases the area and number of islets and number of somatostatin immunopositive cells but reduces relative pancreas weight and effects the morphological and structural development of the pancreas, which may inhibit the pancreatic growth and development in African ostrich chicks.
author	Li,Baitao Li,Peng Wang,Jiaxiang Liu,Siyu Ye,Lixun Pi,Jinsong Peng,Kemei Sun,Qing
author_facet	Li,Baitao Li,Peng Wang,Jiaxiang Liu,Siyu Ye,Lixun Pi,Jinsong Peng,Kemei Sun,Qing
author_sort	Li,Baitao
title	Effects of Exogenous Ghrelin on the Tissue Structure and Somato-Statin Secretion in the Pancreas of African Ostrich Chicks
title_short	Effects of Exogenous Ghrelin on the Tissue Structure and Somato-Statin Secretion in the Pancreas of African Ostrich Chicks
title_full	Effects of Exogenous Ghrelin on the Tissue Structure and Somato-Statin Secretion in the Pancreas of African Ostrich Chicks
title_fullStr	Effects of Exogenous Ghrelin on the Tissue Structure and Somato-Statin Secretion in the Pancreas of African Ostrich Chicks
title_full_unstemmed	Effects of Exogenous Ghrelin on the Tissue Structure and Somato-Statin Secretion in the Pancreas of African Ostrich Chicks
title_sort	effects of exogenous ghrelin on the tissue structure and somato-statin secretion in the pancreas of african ostrich chicks
publisher	Sociedad Chilena de Anatomía
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000501459
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Effects of Exogenous Ghrelin on the Tissue Structure and Somato-Statin Secretion in the Pancreas of African Ostrich Chicks

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