QUANTUM YIELDS OF SINGLET MOLECULAR OXYGEN, O2(¹deltag), PRODUCED BY ANTIMALARIC DRUGS IN ORGANIC SOLVENTS

Detection of singlet molecular oxygen, O2(1delta g), by phosphorescence emission, lambda = 1270 nm, following laser excitation was employed to measure the quantum yield of O2(1delta g) generation by the antimalaric drugs quinine, quinacrine, chloroquine and primaquine in several organic solvents. Th...

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Autores principales:	Valencia U,Cristina, Lemp,Else, L. Zanocco,Antonio
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2003
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072003000400003
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spelling	oai:scielo:S0717-970720030004000032004-04-26QUANTUM YIELDS OF SINGLET MOLECULAR OXYGEN, O2(¹deltag), PRODUCED BY ANTIMALARIC DRUGS IN ORGANIC SOLVENTSValencia U,CristinaLemp,ElseL. Zanocco,AntonioDetection of singlet molecular oxygen, O2(1delta g), by phosphorescence emission, lambda = 1270 nm, following laser excitation was employed to measure the quantum yield of O2(1delta g) generation by the antimalaric drugs quinine, quinacrine, chloroquine and primaquine in several organic solvents. The same method was employed to measure total rate constants, kT, for quenching (physical and chemical) of O2(¹deltag) by the antimalaric drugs. All drugs studied sensitize singlet oxygen formation in organic media. Quinine was the most efficient sensitizer in the four solvents employed. Three of the drugs under study, quinine, quinacrine and chloroquine, produced efficiently singlet molecular oxygen in ethanol. Also, the antimalaric drugs are relatively efficient quenchers of singlet oxygen. Values of kT range from (0.63 ± 0.02) x 10(7) M-1 s-1 for primaquine in hexane to (17.1 ± 0.30) x 10(7) M-1 s-1 for primaquine in acetonitrile. Data obtained show that undesirable adverse cutaneous and ocular side effects associated to the malaria treatments with these drugs could be related at least partially to their ability to produce singlet molecular oxygen in particular if the drug is present in low polarity microenvironments in biological systemsinfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.48 n.4 20032003-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072003000400003en10.4067/S0717-97072003000400003
institution	Scielo Chile
collection	Scielo Chile
language	English
description	Detection of singlet molecular oxygen, O2(1delta g), by phosphorescence emission, lambda = 1270 nm, following laser excitation was employed to measure the quantum yield of O2(1delta g) generation by the antimalaric drugs quinine, quinacrine, chloroquine and primaquine in several organic solvents. The same method was employed to measure total rate constants, kT, for quenching (physical and chemical) of O2(¹deltag) by the antimalaric drugs. All drugs studied sensitize singlet oxygen formation in organic media. Quinine was the most efficient sensitizer in the four solvents employed. Three of the drugs under study, quinine, quinacrine and chloroquine, produced efficiently singlet molecular oxygen in ethanol. Also, the antimalaric drugs are relatively efficient quenchers of singlet oxygen. Values of kT range from (0.63 ± 0.02) x 10(7) M-1 s-1 for primaquine in hexane to (17.1 ± 0.30) x 10(7) M-1 s-1 for primaquine in acetonitrile. Data obtained show that undesirable adverse cutaneous and ocular side effects associated to the malaria treatments with these drugs could be related at least partially to their ability to produce singlet molecular oxygen in particular if the drug is present in low polarity microenvironments in biological systems
author	Valencia U,Cristina Lemp,Else L. Zanocco,Antonio
spellingShingle	Valencia U,Cristina Lemp,Else L. Zanocco,Antonio QUANTUM YIELDS OF SINGLET MOLECULAR OXYGEN, O2(¹deltag), PRODUCED BY ANTIMALARIC DRUGS IN ORGANIC SOLVENTS
author_facet	Valencia U,Cristina Lemp,Else L. Zanocco,Antonio
author_sort	Valencia U,Cristina
title	QUANTUM YIELDS OF SINGLET MOLECULAR OXYGEN, O2(¹deltag), PRODUCED BY ANTIMALARIC DRUGS IN ORGANIC SOLVENTS
title_short	QUANTUM YIELDS OF SINGLET MOLECULAR OXYGEN, O2(¹deltag), PRODUCED BY ANTIMALARIC DRUGS IN ORGANIC SOLVENTS
title_full	QUANTUM YIELDS OF SINGLET MOLECULAR OXYGEN, O2(¹deltag), PRODUCED BY ANTIMALARIC DRUGS IN ORGANIC SOLVENTS
title_fullStr	QUANTUM YIELDS OF SINGLET MOLECULAR OXYGEN, O2(¹deltag), PRODUCED BY ANTIMALARIC DRUGS IN ORGANIC SOLVENTS
title_full_unstemmed	QUANTUM YIELDS OF SINGLET MOLECULAR OXYGEN, O2(¹deltag), PRODUCED BY ANTIMALARIC DRUGS IN ORGANIC SOLVENTS
title_sort	quantum yields of singlet molecular oxygen, o2(¹deltag), produced by antimalaric drugs in organic solvents
publisher	Sociedad Chilena de Química
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072003000400003
work_keys_str_mv	AT valenciaucristina quantumyieldsofsingletmolecularoxygeno21deltagproducedbyantimalaricdrugsinorganicsolvents AT lempelse quantumyieldsofsingletmolecularoxygeno21deltagproducedbyantimalaricdrugsinorganicsolvents AT lzanoccoantonio quantumyieldsofsingletmolecularoxygeno21deltagproducedbyantimalaricdrugsinorganicsolvents
_version_	1718445329860263936

QUANTUM YIELDS OF SINGLET MOLECULAR OXYGEN, O2(¹deltag), PRODUCED BY ANTIMALARIC DRUGS IN ORGANIC SOLVENTS

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