ESR AND SPIN TRAPPING STUDIES OF TWO NEW POTENTIAL NTITRYPANOSOMAL DRUGS

The Electron Spin Resonance (ESR) spectra of radicals obtained from two new potential antitrypanosomal drugs by Trypanosoma cruzi reduction were analyzed. DMPO Spin Trapping was used to investigate the possible formation of free radicals in the trypanosome microsomal system. The Nitro 2 (4-(n-butyl)...

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Autores principales:	Olea-Azar,Claudio, Rigol,Carolina, Opazo,Lucía, Morello,Antonio, Maya,Juan Diego, Repetto,Yolanda, Aguirre,Gabriela, Cerecetto,Hugo, Di Maio,Rossanna, González,Mercedes, Porca,Williams
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2003
Materias:	Nitrofuran derivatives N-Oxide derivatives ROS scavenging ESR spin trapping T. cruzi oxidative stress
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072003000400012
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record_format	dspace
spelling	oai:scielo:S0717-970720030004000122004-04-26ESR AND SPIN TRAPPING STUDIES OF TWO NEW POTENTIAL NTITRYPANOSOMAL DRUGSOlea-Azar,ClaudioRigol,CarolinaOpazo,LucíaMorello,AntonioMaya,Juan DiegoRepetto,YolandaAguirre,GabrielaCerecetto,HugoDi Maio,RossannaGonzález,MercedesPorca,Williams Nitrofuran derivatives N-Oxide derivatives ROS scavenging ESR spin trapping T. cruzi oxidative stress The Electron Spin Resonance (ESR) spectra of radicals obtained from two new potential antitrypanosomal drugs by Trypanosoma cruzi reduction were analyzed. DMPO Spin Trapping was used to investigate the possible formation of free radicals in the trypanosome microsomal system. The Nitro 2 (4-(n-butyl)-1-(5-nitrofurfurylidene)semicarbazide) analogue of Nifurtimox showed better antiparasitic activity than N-oxide 1 (4-(n-butyl)-1-[(7-bromo-N1-oxidebenzo[1,2-c]1,2,5-oxadiazole-5-yl)methylidene]semicarbazide). Only Nitro 2 could produce oxygen redox cycling in T. cruzi epimastigotes. The ESR signal intensities were consistent with the trapping of hydroxyl radical. These results are in agreement with the biological observation that Nitro 2 showed antichagasic activity by an oxidative stress mechanisminfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.48 n.4 20032003-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072003000400012en10.4067/S0717-97072003000400012
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Nitrofuran derivatives N-Oxide derivatives ROS scavenging ESR spin trapping T. cruzi oxidative stress
spellingShingle	Nitrofuran derivatives N-Oxide derivatives ROS scavenging ESR spin trapping T. cruzi oxidative stress Olea-Azar,Claudio Rigol,Carolina Opazo,Lucía Morello,Antonio Maya,Juan Diego Repetto,Yolanda Aguirre,Gabriela Cerecetto,Hugo Di Maio,Rossanna González,Mercedes Porca,Williams ESR AND SPIN TRAPPING STUDIES OF TWO NEW POTENTIAL NTITRYPANOSOMAL DRUGS
description	The Electron Spin Resonance (ESR) spectra of radicals obtained from two new potential antitrypanosomal drugs by Trypanosoma cruzi reduction were analyzed. DMPO Spin Trapping was used to investigate the possible formation of free radicals in the trypanosome microsomal system. The Nitro 2 (4-(n-butyl)-1-(5-nitrofurfurylidene)semicarbazide) analogue of Nifurtimox showed better antiparasitic activity than N-oxide 1 (4-(n-butyl)-1-[(7-bromo-N1-oxidebenzo[1,2-c]1,2,5-oxadiazole-5-yl)methylidene]semicarbazide). Only Nitro 2 could produce oxygen redox cycling in T. cruzi epimastigotes. The ESR signal intensities were consistent with the trapping of hydroxyl radical. These results are in agreement with the biological observation that Nitro 2 showed antichagasic activity by an oxidative stress mechanism
author	Olea-Azar,Claudio Rigol,Carolina Opazo,Lucía Morello,Antonio Maya,Juan Diego Repetto,Yolanda Aguirre,Gabriela Cerecetto,Hugo Di Maio,Rossanna González,Mercedes Porca,Williams
author_facet	Olea-Azar,Claudio Rigol,Carolina Opazo,Lucía Morello,Antonio Maya,Juan Diego Repetto,Yolanda Aguirre,Gabriela Cerecetto,Hugo Di Maio,Rossanna González,Mercedes Porca,Williams
author_sort	Olea-Azar,Claudio
title	ESR AND SPIN TRAPPING STUDIES OF TWO NEW POTENTIAL NTITRYPANOSOMAL DRUGS
title_short	ESR AND SPIN TRAPPING STUDIES OF TWO NEW POTENTIAL NTITRYPANOSOMAL DRUGS
title_full	ESR AND SPIN TRAPPING STUDIES OF TWO NEW POTENTIAL NTITRYPANOSOMAL DRUGS
title_fullStr	ESR AND SPIN TRAPPING STUDIES OF TWO NEW POTENTIAL NTITRYPANOSOMAL DRUGS
title_full_unstemmed	ESR AND SPIN TRAPPING STUDIES OF TWO NEW POTENTIAL NTITRYPANOSOMAL DRUGS
title_sort	esr and spin trapping studies of two new potential ntitrypanosomal drugs
publisher	Sociedad Chilena de Química
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072003000400012
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ESR AND SPIN TRAPPING STUDIES OF TWO NEW POTENTIAL NTITRYPANOSOMAL DRUGS

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