SYNTHESIS AND CHARACTERIZATION OF CARBOXYMETHYL CHITOSAN-ARG AND CARBOXYMETHYL CHITOSAN-LYS DERIVATIVES

One of the properties of chitosan is their capacity to trap cholesterol. Following this reasoning the incorporation of more amino and alkyl groups will increase the charge density in the macromolecule increasing the capability to retain bilic acids. A series of products from chitosan were prepared f...

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Autores principales:	Cárdenas,Galo, Cuellar,J. Daniel, Neira,Karem
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2004
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072004000300009
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spelling	oai:scielo:S0717-970720040003000092006-03-21SYNTHESIS AND CHARACTERIZATION OF CARBOXYMETHYL CHITOSAN-ARG AND CARBOXYMETHYL CHITOSAN-LYS DERIVATIVESCárdenas,GaloCuellar,J. DanielNeira,KaremOne of the properties of chitosan is their capacity to trap cholesterol. Following this reasoning the incorporation of more amino and alkyl groups will increase the charge density in the macromolecule increasing the capability to retain bilic acids. A series of products from chitosan were prepared from the precursor carboxymethyl chitosan (CMQ). The aminoacids arginine and lysine were methylated in order to direct the amide bond formation and selectively incorporated in carboxymethyl chitosan macromolecule (CMQ-ARG and CMQ-LYS). Preliminary results of "in vitro" retention capacity in human hypercholesterolemic serum are reported. The cholesterol retention capacity was 49.62 ± 1.66 % for CMQ-ARG and 43.72 ± 1.65 % for CMQ-LYS using a 80 mg/mL polymer concentration. On the other hand, the chitosan show a 14.23 ± 0.81 % retention capacity. The increase in the amino group in chitosan derivatives increase the change density to improve the total binding capacity in vitroinfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.49 n.3 20042004-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072004000300009en10.4067/S0717-97072004000300009
institution	Scielo Chile
collection	Scielo Chile
language	English
description	One of the properties of chitosan is their capacity to trap cholesterol. Following this reasoning the incorporation of more amino and alkyl groups will increase the charge density in the macromolecule increasing the capability to retain bilic acids. A series of products from chitosan were prepared from the precursor carboxymethyl chitosan (CMQ). The aminoacids arginine and lysine were methylated in order to direct the amide bond formation and selectively incorporated in carboxymethyl chitosan macromolecule (CMQ-ARG and CMQ-LYS). Preliminary results of "in vitro" retention capacity in human hypercholesterolemic serum are reported. The cholesterol retention capacity was 49.62 ± 1.66 % for CMQ-ARG and 43.72 ± 1.65 % for CMQ-LYS using a 80 mg/mL polymer concentration. On the other hand, the chitosan show a 14.23 ± 0.81 % retention capacity. The increase in the amino group in chitosan derivatives increase the change density to improve the total binding capacity in vitro
author	Cárdenas,Galo Cuellar,J. Daniel Neira,Karem
spellingShingle	Cárdenas,Galo Cuellar,J. Daniel Neira,Karem SYNTHESIS AND CHARACTERIZATION OF CARBOXYMETHYL CHITOSAN-ARG AND CARBOXYMETHYL CHITOSAN-LYS DERIVATIVES
author_facet	Cárdenas,Galo Cuellar,J. Daniel Neira,Karem
author_sort	Cárdenas,Galo
title	SYNTHESIS AND CHARACTERIZATION OF CARBOXYMETHYL CHITOSAN-ARG AND CARBOXYMETHYL CHITOSAN-LYS DERIVATIVES
title_short	SYNTHESIS AND CHARACTERIZATION OF CARBOXYMETHYL CHITOSAN-ARG AND CARBOXYMETHYL CHITOSAN-LYS DERIVATIVES
title_full	SYNTHESIS AND CHARACTERIZATION OF CARBOXYMETHYL CHITOSAN-ARG AND CARBOXYMETHYL CHITOSAN-LYS DERIVATIVES
title_fullStr	SYNTHESIS AND CHARACTERIZATION OF CARBOXYMETHYL CHITOSAN-ARG AND CARBOXYMETHYL CHITOSAN-LYS DERIVATIVES
title_full_unstemmed	SYNTHESIS AND CHARACTERIZATION OF CARBOXYMETHYL CHITOSAN-ARG AND CARBOXYMETHYL CHITOSAN-LYS DERIVATIVES
title_sort	synthesis and characterization of carboxymethyl chitosan-arg and carboxymethyl chitosan-lys derivatives
publisher	Sociedad Chilena de Química
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072004000300009
work_keys_str_mv	AT cardenasgalo synthesisandcharacterizationofcarboxymethylchitosanargandcarboxymethylchitosanlysderivatives AT cuellarjdaniel synthesisandcharacterizationofcarboxymethylchitosanargandcarboxymethylchitosanlysderivatives AT neirakarem synthesisandcharacterizationofcarboxymethylchitosanargandcarboxymethylchitosanlysderivatives
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SYNTHESIS AND CHARACTERIZATION OF CARBOXYMETHYL CHITOSAN-ARG AND CARBOXYMETHYL CHITOSAN-LYS DERIVATIVES

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