A STRUCTURE-AFFINITY STUDY OF THE OPIOID BINDING OF SOME 3-SUBSTITUTED MORPHINANS

A ZINDO/1 quantum-chemical structure-affinity relationship study is presented for the interaction of a group of 3-substituted morphinans with mu, delta and kappa opioid receptors. From this and previous work it is concluded that: 1. Receptor selectivity is regulated by different electronic densities...

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Autores principales: GÓMEZ-JERIA,JUAN SEBASTIÁN, GERLI-CANDIA,LORENA A, HURTADO,S. MARCELA
Lenguaje:English
Publicado: Sociedad Chilena de Química 2004
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072004000400008
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