A CONVENIENT, RENEWABLE SOURCE OF THE ANXIOLYTIC PROAPORPHINE ALKALOID GLAZIOVINE: DUGUETIA VALLICOLA LEAVES

The leaves of Duguetia vallicola, a fairly common, large evergreen tree from the coastal regions of Panama, Colombia and Venezuela, contain (6aS)-glaziovine (1) as a major constituent. The abundance and renewable character of the plant material make it an attractive source for this rare, psychoactiv...

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Autores principales: PÉREZ,EDWIN G., SÁEZ,JAIRO, CASSELS,BRUCE K.
Lenguaje:English
Publicado: Sociedad Chilena de Química 2005
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072005000300005
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Sumario:The leaves of Duguetia vallicola, a fairly common, large evergreen tree from the coastal regions of Panama, Colombia and Venezuela, contain (6aS)-glaziovine (1) as a major constituent. The abundance and renewable character of the plant material make it an attractive source for this rare, psychoactive alkaloid. The availability of glaziovine and its O-methyl derivative pronuciferine (2) has made complete ¹H and 13C NMR assignments of proaporphines possible for the first time