LIPID PEROXIDATION RATES OF DPPC LIPOSOMES CONTAINING DIFFERENT AMOUNTS OF OXIDABLE LIPIDS SHOW OPPOSITE DEPENDENCE WITH THE TEMPERATURE

The effect of temperature on the oxidation rates of arachidonic acid and linoleic acid incorporated into dipalmitoylphosphatidylcholine liposomes have been investigated. The reaction was started by the photolysis of 2,2'-azobis (2-amidino propane) in order to minimize the dependence of the init...

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Autores principales:	CUBILLOS,MARÍA, LISSI,EDUARDO, ABUIN,ELSA
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2006
Materias:	lipid peroxidation linoleic acid arachidonic acid dipalmitoyl- phosphatidylcholine
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072006000100013
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spelling	oai:scielo:S0717-970720060001000132006-06-08LIPID PEROXIDATION RATES OF DPPC LIPOSOMES CONTAINING DIFFERENT AMOUNTS OF OXIDABLE LIPIDS SHOW OPPOSITE DEPENDENCE WITH THE TEMPERATURECUBILLOS,MARÍALISSI,EDUARDOABUIN,ELSA lipid peroxidation linoleic acid arachidonic acid dipalmitoyl- phosphatidylcholine The effect of temperature on the oxidation rates of arachidonic acid and linoleic acid incorporated into dipalmitoylphosphatidylcholine liposomes have been investigated. The reaction was started by the photolysis of 2,2'-azobis (2-amidino propane) in order to minimize the dependence of the initiation rate with temperature. Both positive and negative activation energies were obtained for the rate of the oxidation, depending on the amount of oxidable lipid (20% or 50% mol:mol) and the temperature range considered. Changes in the rigidity of the liposomes elicited by temperature were assessed by measuring the generalized polarization of 6-dodecanoyl-2 (dimethylamino naphthalene), Laurdan. The high increase in rate observed at low temperatures employing lipid mixtures that render liposomes in the gel phase is attributed to a reduced rate constant of the termination step of the oxidation chaininfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.51 n.1 20062006-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072006000100013en10.4067/S0717-97072006000100013
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	lipid peroxidation linoleic acid arachidonic acid dipalmitoyl- phosphatidylcholine
spellingShingle	lipid peroxidation linoleic acid arachidonic acid dipalmitoyl- phosphatidylcholine CUBILLOS,MARÍA LISSI,EDUARDO ABUIN,ELSA LIPID PEROXIDATION RATES OF DPPC LIPOSOMES CONTAINING DIFFERENT AMOUNTS OF OXIDABLE LIPIDS SHOW OPPOSITE DEPENDENCE WITH THE TEMPERATURE
description	The effect of temperature on the oxidation rates of arachidonic acid and linoleic acid incorporated into dipalmitoylphosphatidylcholine liposomes have been investigated. The reaction was started by the photolysis of 2,2'-azobis (2-amidino propane) in order to minimize the dependence of the initiation rate with temperature. Both positive and negative activation energies were obtained for the rate of the oxidation, depending on the amount of oxidable lipid (20% or 50% mol:mol) and the temperature range considered. Changes in the rigidity of the liposomes elicited by temperature were assessed by measuring the generalized polarization of 6-dodecanoyl-2 (dimethylamino naphthalene), Laurdan. The high increase in rate observed at low temperatures employing lipid mixtures that render liposomes in the gel phase is attributed to a reduced rate constant of the termination step of the oxidation chain
author	CUBILLOS,MARÍA LISSI,EDUARDO ABUIN,ELSA
author_facet	CUBILLOS,MARÍA LISSI,EDUARDO ABUIN,ELSA
author_sort	CUBILLOS,MARÍA
title	LIPID PEROXIDATION RATES OF DPPC LIPOSOMES CONTAINING DIFFERENT AMOUNTS OF OXIDABLE LIPIDS SHOW OPPOSITE DEPENDENCE WITH THE TEMPERATURE
title_short	LIPID PEROXIDATION RATES OF DPPC LIPOSOMES CONTAINING DIFFERENT AMOUNTS OF OXIDABLE LIPIDS SHOW OPPOSITE DEPENDENCE WITH THE TEMPERATURE
title_full	LIPID PEROXIDATION RATES OF DPPC LIPOSOMES CONTAINING DIFFERENT AMOUNTS OF OXIDABLE LIPIDS SHOW OPPOSITE DEPENDENCE WITH THE TEMPERATURE
title_fullStr	LIPID PEROXIDATION RATES OF DPPC LIPOSOMES CONTAINING DIFFERENT AMOUNTS OF OXIDABLE LIPIDS SHOW OPPOSITE DEPENDENCE WITH THE TEMPERATURE
title_full_unstemmed	LIPID PEROXIDATION RATES OF DPPC LIPOSOMES CONTAINING DIFFERENT AMOUNTS OF OXIDABLE LIPIDS SHOW OPPOSITE DEPENDENCE WITH THE TEMPERATURE
title_sort	lipid peroxidation rates of dppc liposomes containing different amounts of oxidable lipids show opposite dependence with the temperature
publisher	Sociedad Chilena de Química
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072006000100013
work_keys_str_mv	AT cubillosmaria lipidperoxidationratesofdppcliposomescontainingdifferentamountsofoxidablelipidsshowoppositedependencewiththetemperature AT lissieduardo lipidperoxidationratesofdppcliposomescontainingdifferentamountsofoxidablelipidsshowoppositedependencewiththetemperature AT abuinelsa lipidperoxidationratesofdppcliposomescontainingdifferentamountsofoxidablelipidsshowoppositedependencewiththetemperature
_version_	1718445358857584640

LIPID PEROXIDATION RATES OF DPPC LIPOSOMES CONTAINING DIFFERENT AMOUNTS OF OXIDABLE LIPIDS SHOW OPPOSITE DEPENDENCE WITH THE TEMPERATURE

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