ALKALOIDS AND A FLAVONOID FROM AERIAL PARTS (LEAVES AND TWIGS) OF DUGUETIA FURFURACEA - ANNONACEAE

Duguetia furfuracea is a shrub of the Annonaceae family that occurs in several regions in Brazil. In the state of Mato Grosso do Sul this species often becomes an invading plant when the cerrado is turned into pastures. In the local folk medicine, its powdered seeds are mixed with water and used aga...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Carollo,Carlos Alexandre, Hellmann-Carollo,Aline Regina, Siqueira,João Máximo de, Albuquerque,Sérgio
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2006
Materias:	Duguetia furfuracea Annonaceae alkaloid flavonoid Trypanosoma cruzi
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072006000200001
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-97072006000200001
record_format	dspace
spelling	oai:scielo:S0717-970720060002000012006-06-30ALKALOIDS AND A FLAVONOID FROM AERIAL PARTS (LEAVES AND TWIGS) OF DUGUETIA FURFURACEA - ANNONACEAECarollo,Carlos AlexandreHellmann-Carollo,Aline ReginaSiqueira,João Máximo deAlbuquerque,Sérgio Duguetia furfuracea Annonaceae alkaloid flavonoid Trypanosoma cruzi Duguetia furfuracea is a shrub of the Annonaceae family that occurs in several regions in Brazil. In the state of Mato Grosso do Sul this species often becomes an invading plant when the cerrado is turned into pastures. In the local folk medicine, its powdered seeds are mixed with water and used against pediculosis, and the infusion of twigs and leaves is used to treat rheumatism.. The present work led to the isolation and characterization from the aerial parts of the plant (leaves and twigs), of twelve isoquinoline alkaloids of aporphine oxoaporphine, bisbenzyltetrahydro-isoquinoline, benzyltetrahydro-isoquinoline and tetrahydroprotoberberine skeletons. In addition b-sytosterol and the flavonoid isorhamnethin were obtained. The activity of these different patterns of isoquinoline skeleton and the flavonoid was tested against Trypanosoma cruzi, and only aporphinoid skeleton with (R)-configuration, (-)-asimilobine, was really effective against trypomastigotes (strain Y), killing approximately 72% of the parasites at a maximal concentration of 128.0 mM (IC50 57.2 mM). The trypanocidal activity of the alkaloids and the flavonoid have been investigatedinfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.51 n.2 20062006-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072006000200001en10.4067/S0717-97072006000200001
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Duguetia furfuracea Annonaceae alkaloid flavonoid Trypanosoma cruzi
spellingShingle	Duguetia furfuracea Annonaceae alkaloid flavonoid Trypanosoma cruzi Carollo,Carlos Alexandre Hellmann-Carollo,Aline Regina Siqueira,João Máximo de Albuquerque,Sérgio ALKALOIDS AND A FLAVONOID FROM AERIAL PARTS (LEAVES AND TWIGS) OF DUGUETIA FURFURACEA - ANNONACEAE
description	Duguetia furfuracea is a shrub of the Annonaceae family that occurs in several regions in Brazil. In the state of Mato Grosso do Sul this species often becomes an invading plant when the cerrado is turned into pastures. In the local folk medicine, its powdered seeds are mixed with water and used against pediculosis, and the infusion of twigs and leaves is used to treat rheumatism.. The present work led to the isolation and characterization from the aerial parts of the plant (leaves and twigs), of twelve isoquinoline alkaloids of aporphine oxoaporphine, bisbenzyltetrahydro-isoquinoline, benzyltetrahydro-isoquinoline and tetrahydroprotoberberine skeletons. In addition b-sytosterol and the flavonoid isorhamnethin were obtained. The activity of these different patterns of isoquinoline skeleton and the flavonoid was tested against Trypanosoma cruzi, and only aporphinoid skeleton with (R)-configuration, (-)-asimilobine, was really effective against trypomastigotes (strain Y), killing approximately 72% of the parasites at a maximal concentration of 128.0 mM (IC50 57.2 mM). The trypanocidal activity of the alkaloids and the flavonoid have been investigated
author	Carollo,Carlos Alexandre Hellmann-Carollo,Aline Regina Siqueira,João Máximo de Albuquerque,Sérgio
author_facet	Carollo,Carlos Alexandre Hellmann-Carollo,Aline Regina Siqueira,João Máximo de Albuquerque,Sérgio
author_sort	Carollo,Carlos Alexandre
title	ALKALOIDS AND A FLAVONOID FROM AERIAL PARTS (LEAVES AND TWIGS) OF DUGUETIA FURFURACEA - ANNONACEAE
title_short	ALKALOIDS AND A FLAVONOID FROM AERIAL PARTS (LEAVES AND TWIGS) OF DUGUETIA FURFURACEA - ANNONACEAE
title_full	ALKALOIDS AND A FLAVONOID FROM AERIAL PARTS (LEAVES AND TWIGS) OF DUGUETIA FURFURACEA - ANNONACEAE
title_fullStr	ALKALOIDS AND A FLAVONOID FROM AERIAL PARTS (LEAVES AND TWIGS) OF DUGUETIA FURFURACEA - ANNONACEAE
title_full_unstemmed	ALKALOIDS AND A FLAVONOID FROM AERIAL PARTS (LEAVES AND TWIGS) OF DUGUETIA FURFURACEA - ANNONACEAE
title_sort	alkaloids and a flavonoid from aerial parts (leaves and twigs) of duguetia furfuracea - annonaceae
publisher	Sociedad Chilena de Química
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072006000200001
work_keys_str_mv	AT carollocarlosalexandre alkaloidsandaflavonoidfromaerialpartsleavesandtwigsofduguetiafurfuraceaannonaceae AT hellmanncarolloalineregina alkaloidsandaflavonoidfromaerialpartsleavesandtwigsofduguetiafurfuraceaannonaceae AT siqueirajoaomaximode alkaloidsandaflavonoidfromaerialpartsleavesandtwigsofduguetiafurfuraceaannonaceae AT albuquerquesergio alkaloidsandaflavonoidfromaerialpartsleavesandtwigsofduguetiafurfuraceaannonaceae
_version_	1718445359201517568

ALKALOIDS AND A FLAVONOID FROM AERIAL PARTS (LEAVES AND TWIGS) OF DUGUETIA FURFURACEA - ANNONACEAE

Ejemplares similares