SYNTHESIS, CHARACTERIZATION AND IN VITRO ANTIFUNGAL EVALUATION OF NOVEL BENZIMIDAZO[1,2-c]QUINAZOLINES
The synthesis of a series of new benzimidazo[1,2-c]quinazolines starting from 2-nitrobenzaldehyde and o-phenylendiamine is described. The structure elucidation of the products is based on detailed NMR analysis of experiments such as ¹H-COSY, NOESY, DEPT, HSQC and HMBC. These compounds showed antifun...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Lenguaje: | English |
| Publicado: |
Sociedad Chilena de Química
2006
|
| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072006000200018 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: | The synthesis of a series of new benzimidazo[1,2-c]quinazolines starting from 2-nitrobenzaldehyde and o-phenylendiamine is described. The structure elucidation of the products is based on detailed NMR analysis of experiments such as ¹H-COSY, NOESY, DEPT, HSQC and HMBC. These compounds showed antifungal properties only against dermatophytes. Among them, those with electron-donor substituents on the 6-phenyl ring inhibited mainly T. rubrum and E. floccosum with MICs between 25-250 µg/mL and M. canis, M. gypseum and T. mentagrophytes with MICs between 50-250 µg/mL. Structures with electron-withdrawing substituents on the phenyl ring did not show any activities up to 250 µg/ml. Methyl substituents on the benzimidazole ring seem negatively affect the antifungal behaviour of this series |
|---|