SYNTHESIS AND RESOLUTION OF THE OPTICAL ISOMERS OF THIENCYNONATE HYDROCHLORIDE

Thiencynonate hydrochloride (N-methyL-9á-(3-azabicyclo[3,3,1]nonanyl)-2'-cyclopentyL-2'- hydroxyL-2'-thienylacetate, I·HCl), an new muscarinic receptor antagonist, was synthesized and its enantiomers were obtained form the optical pure of demethylation product II. A convenient resolut...

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Autores principales:	LIU,HE, LIU,LI-PING, WANG,JING-LI, ZHONG,BO-HUA, LIU,KE-LIANG
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2006
Materias:	Thiencynonate hydrochloride optical resolution anticholinergic Drug
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072006000300006
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spelling	oai:scielo:S0717-970720060003000062006-11-16SYNTHESIS AND RESOLUTION OF THE OPTICAL ISOMERS OF THIENCYNONATE HYDROCHLORIDELIU,HELIU,LI-PINGWANG,JING-LIZHONG,BO-HUALIU,KE-LIANG Thiencynonate hydrochloride optical resolution anticholinergic Drug Thiencynonate hydrochloride (N-methyL-9á-(3-azabicyclo[3,3,1]nonanyl)-2'-cyclopentyL-2'- hydroxyL-2'-thienylacetate, I·HCl), an new muscarinic receptor antagonist, was synthesized and its enantiomers were obtained form the optical pure of demethylation product II. A convenient resolution method of demethylation product II has been developed with N-p- toluenesulfonylglutamic acid as the resolution reagent. The structures of I and II were elucidated by X-ray analysisinfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.51 n.3 20062006-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072006000300006en10.4067/S0717-97072006000300006
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Thiencynonate hydrochloride optical resolution anticholinergic Drug
spellingShingle	Thiencynonate hydrochloride optical resolution anticholinergic Drug LIU,HE LIU,LI-PING WANG,JING-LI ZHONG,BO-HUA LIU,KE-LIANG SYNTHESIS AND RESOLUTION OF THE OPTICAL ISOMERS OF THIENCYNONATE HYDROCHLORIDE
description	Thiencynonate hydrochloride (N-methyL-9á-(3-azabicyclo[3,3,1]nonanyl)-2'-cyclopentyL-2'- hydroxyL-2'-thienylacetate, I·HCl), an new muscarinic receptor antagonist, was synthesized and its enantiomers were obtained form the optical pure of demethylation product II. A convenient resolution method of demethylation product II has been developed with N-p- toluenesulfonylglutamic acid as the resolution reagent. The structures of I and II were elucidated by X-ray analysis
author	LIU,HE LIU,LI-PING WANG,JING-LI ZHONG,BO-HUA LIU,KE-LIANG
author_facet	LIU,HE LIU,LI-PING WANG,JING-LI ZHONG,BO-HUA LIU,KE-LIANG
author_sort	LIU,HE
title	SYNTHESIS AND RESOLUTION OF THE OPTICAL ISOMERS OF THIENCYNONATE HYDROCHLORIDE
title_short	SYNTHESIS AND RESOLUTION OF THE OPTICAL ISOMERS OF THIENCYNONATE HYDROCHLORIDE
title_full	SYNTHESIS AND RESOLUTION OF THE OPTICAL ISOMERS OF THIENCYNONATE HYDROCHLORIDE
title_fullStr	SYNTHESIS AND RESOLUTION OF THE OPTICAL ISOMERS OF THIENCYNONATE HYDROCHLORIDE
title_full_unstemmed	SYNTHESIS AND RESOLUTION OF THE OPTICAL ISOMERS OF THIENCYNONATE HYDROCHLORIDE
title_sort	synthesis and resolution of the optical isomers of thiencynonate hydrochloride
publisher	Sociedad Chilena de Química
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072006000300006
work_keys_str_mv	AT liuhe synthesisandresolutionoftheopticalisomersofthiencynonatehydrochloride AT liuliping synthesisandresolutionoftheopticalisomersofthiencynonatehydrochloride AT wangjingli synthesisandresolutionoftheopticalisomersofthiencynonatehydrochloride AT zhongbohua synthesisandresolutionoftheopticalisomersofthiencynonatehydrochloride AT liukeliang synthesisandresolutionoftheopticalisomersofthiencynonatehydrochloride
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SYNTHESIS AND RESOLUTION OF THE OPTICAL ISOMERS OF THIENCYNONATE HYDROCHLORIDE

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