SYNTHESIS AND CONFORMATIONAL ANALYSIS OF LEPTOCARPIN DERIVATIVES: INFLUENCE OF MODIFICATION OF THE OXIRANE RINGON LEPTOCARPIN'S CYTOTOXIC ACTIVITY

SYNTHESIS AND CONFORMATIONAL ANALYSIS OF LEPTOCARPIN DERIVATIVES: INFLUENCE OF MODIFICATION OF THE OXIRANE RINGON LEPTOCARPIN'S CYTOTOXIC ACTIVITY

The reaction in acidconditions of Leptocarpin 1, a compound with antitumor activity, formed two new isomeric products, 8b-angeloyl-1b,3b-dihydroxy-4,10-dimethyl,-D11(13) methylen-4Z,9Z-dieneheliangol-6,12-olide 2 and 8b-angeloyl-1b,3b-dihydroxy-4-methyl-D11(13),D11(14)-dimethylen-4Z-eneheliangol-6,1...

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Main Authors: MARTÍNEZ,ROLANDO, KESTERNICH,VICTOR, CARRACSO,HÉCTOR, ÁLVAREZ-CONTRERAS,CAROLINA, MONTENEGRO,CAROLINA, UGARTE,RICARDO, GUTIÉRREZ,ELENA, MORENO,JOSÉ, GARCÍA,CARLOS, WERNER,ENRIQUE, CÁRCAMOS,JUAN
Language:English
Published: Sociedad Chilena de Química 2006
Subjects:
Conformational analysis
Heliangolide
Sesquiterpene lactones
Cytotoxicity
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072006000400003
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