THE REACTION OF CYANOACETYLHYDRAZINE WITH w-BROMOACETOPHENONE: NOVEL SYNTHESIS OF 1,3,4-OXADIAZINE, PYRIDAZINE AND COUMARIN DERIVATIVES

The reaction of cyanoacetylhydrazine with co-bromoacetophenone gave the condensation product p-Bromoacetophenone-a-cyanoacetylhydrazone (3). The latter product underwent ready cyclization to give the 1,3,4-oxadiazine derivative 4. The reactivities of either 3 or 4 towards some chemical reagents like...

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Autores principales:	MOHAREB,RAFAT M, IBRAHIM,REHAB A, HO,JONATHAN Z
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2007
Materias:	Cyanoacetylhydrazine 1,3,4-Oxadiazine Pyridazine Toxicity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000100005
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spelling	oai:scielo:S0717-970720070001000052007-05-07THE REACTION OF CYANOACETYLHYDRAZINE WITH w-BROMOACETOPHENONE: NOVEL SYNTHESIS OF 1,3,4-OXADIAZINE, PYRIDAZINE AND COUMARIN DERIVATIVESMOHAREB,RAFAT MIBRAHIM,REHAB AHO,JONATHAN Z Cyanoacetylhydrazine 1,3,4-Oxadiazine Pyridazine Toxicity The reaction of cyanoacetylhydrazine with co-bromoacetophenone gave the condensation product p-Bromoacetophenone-a-cyanoacetylhydrazone (3). The latter product underwent ready cyclization to give the 1,3,4-oxadiazine derivative 4. The reactivities of either 3 or 4 towards some chemical reagents like cyanomethylene reagents, diazonium salts, aromatic aldehydes, phenylisothio-cyanate and elemental sulfur were studied to afford 17 newly producís for which the toxicity towards Fusarium oxysporum f. sp. Lycopersici and Helminthosporium oryzea was measured. Moreover their effect towards mycelial dry mass, sporulation and nucleic acid synthesis of Fusarium oxysporum f. sp. Lycopersici was measuredinfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.52 n.1 20072007-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000100005en10.4067/S0717-97072007000100005
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Cyanoacetylhydrazine 1,3,4-Oxadiazine Pyridazine Toxicity
spellingShingle	Cyanoacetylhydrazine 1,3,4-Oxadiazine Pyridazine Toxicity MOHAREB,RAFAT M IBRAHIM,REHAB A HO,JONATHAN Z THE REACTION OF CYANOACETYLHYDRAZINE WITH w-BROMOACETOPHENONE: NOVEL SYNTHESIS OF 1,3,4-OXADIAZINE, PYRIDAZINE AND COUMARIN DERIVATIVES
description	The reaction of cyanoacetylhydrazine with co-bromoacetophenone gave the condensation product p-Bromoacetophenone-a-cyanoacetylhydrazone (3). The latter product underwent ready cyclization to give the 1,3,4-oxadiazine derivative 4. The reactivities of either 3 or 4 towards some chemical reagents like cyanomethylene reagents, diazonium salts, aromatic aldehydes, phenylisothio-cyanate and elemental sulfur were studied to afford 17 newly producís for which the toxicity towards Fusarium oxysporum f. sp. Lycopersici and Helminthosporium oryzea was measured. Moreover their effect towards mycelial dry mass, sporulation and nucleic acid synthesis of Fusarium oxysporum f. sp. Lycopersici was measured
author	MOHAREB,RAFAT M IBRAHIM,REHAB A HO,JONATHAN Z
author_facet	MOHAREB,RAFAT M IBRAHIM,REHAB A HO,JONATHAN Z
author_sort	MOHAREB,RAFAT M
title	THE REACTION OF CYANOACETYLHYDRAZINE WITH w-BROMOACETOPHENONE: NOVEL SYNTHESIS OF 1,3,4-OXADIAZINE, PYRIDAZINE AND COUMARIN DERIVATIVES
title_short	THE REACTION OF CYANOACETYLHYDRAZINE WITH w-BROMOACETOPHENONE: NOVEL SYNTHESIS OF 1,3,4-OXADIAZINE, PYRIDAZINE AND COUMARIN DERIVATIVES
title_full	THE REACTION OF CYANOACETYLHYDRAZINE WITH w-BROMOACETOPHENONE: NOVEL SYNTHESIS OF 1,3,4-OXADIAZINE, PYRIDAZINE AND COUMARIN DERIVATIVES
title_fullStr	THE REACTION OF CYANOACETYLHYDRAZINE WITH w-BROMOACETOPHENONE: NOVEL SYNTHESIS OF 1,3,4-OXADIAZINE, PYRIDAZINE AND COUMARIN DERIVATIVES
title_full_unstemmed	THE REACTION OF CYANOACETYLHYDRAZINE WITH w-BROMOACETOPHENONE: NOVEL SYNTHESIS OF 1,3,4-OXADIAZINE, PYRIDAZINE AND COUMARIN DERIVATIVES
title_sort	reaction of cyanoacetylhydrazine with w-bromoacetophenone: novel synthesis of 1,3,4-oxadiazine, pyridazine and coumarin derivatives
publisher	Sociedad Chilena de Química
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000100005
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THE REACTION OF CYANOACETYLHYDRAZINE WITH w-BROMOACETOPHENONE: NOVEL SYNTHESIS OF 1,3,4-OXADIAZINE, PYRIDAZINE AND COUMARIN DERIVATIVES

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