IN VITRO TRYPANOCIDAL ACTIVITY AND CHEMICAL CONSTITUENTS OF ASPILIA PLATYPHYLLA (BAKER) BLAKE

Chloroform and ethanol crude extracts of the underground parts of Aspilia platyphylla (Baker) Blake (Asteraceae - Heliantheae) were submitted to phytochemical investigations and trypanocidal assay. Both extracts were subjected to a partition process with organic solvents. Using a GC analysis method,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	VENEZIANI,RODRIGO C. S., DE OLIVEIRA,DIONÉIA C. R., ALBUQUERQUE,SÉRGIO, CUNHA,WILSON R.
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2007
Materias:	Aspilia platyphylla Diterpenes Trypanocidal Activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000100008
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-97072007000100008
record_format	dspace
spelling	oai:scielo:S0717-970720070001000082007-05-07IN VITRO TRYPANOCIDAL ACTIVITY AND CHEMICAL CONSTITUENTS OF ASPILIA PLATYPHYLLA (BAKER) BLAKEVENEZIANI,RODRIGO C. S.DE OLIVEIRA,DIONÉIA C. R.ALBUQUERQUE,SÉRGIOCUNHA,WILSON R. Aspilia platyphylla Diterpenes Trypanocidal Activity Chloroform and ethanol crude extracts of the underground parts of Aspilia platyphylla (Baker) Blake (Asteraceae - Heliantheae) were submitted to phytochemical investigations and trypanocidal assay. Both extracts were subjected to a partition process with organic solvents. Using a GC analysis method, it was possible to identify the tritepernes β-amyrin, α-amyrin, β-friedelanol, and friedelin, as well as the phytosterol stigmasterol, directly in the n-hexane soluble fraction obtained from the CHCl3 crude extract. Through chromatographic methods and spectroscopic techniques, it was possible to isolate and identify ent-pimara-8(14), 15-dien-19-oic acid; 7-keto-ent-pimara-8(14),15-dien-19-oic acid; 6-acethyl-8-hydroxy-2,2-dimethylchromene; 7β-hydroxy-ent-pimara-8(14),15-dien-19-oic acid; ethyl 6,7-dihydroxycinammate, and rutin in the CH2Cl2 and AcOEt soluble fractions obtained from the CHCl3 and EtOH crude extracts. The CH2Cl2 soluble fractions obtained from the CHCl3 and EtOH crude extracts are active in vitro against the trypomastigote forms of Trypanossoma cruzi (Y strain)info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.52 n.1 20072007-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000100008en10.4067/S0717-97072007000100008
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Aspilia platyphylla Diterpenes Trypanocidal Activity
spellingShingle	Aspilia platyphylla Diterpenes Trypanocidal Activity VENEZIANI,RODRIGO C. S. DE OLIVEIRA,DIONÉIA C. R. ALBUQUERQUE,SÉRGIO CUNHA,WILSON R. IN VITRO TRYPANOCIDAL ACTIVITY AND CHEMICAL CONSTITUENTS OF ASPILIA PLATYPHYLLA (BAKER) BLAKE
description	Chloroform and ethanol crude extracts of the underground parts of Aspilia platyphylla (Baker) Blake (Asteraceae - Heliantheae) were submitted to phytochemical investigations and trypanocidal assay. Both extracts were subjected to a partition process with organic solvents. Using a GC analysis method, it was possible to identify the tritepernes β-amyrin, α-amyrin, β-friedelanol, and friedelin, as well as the phytosterol stigmasterol, directly in the n-hexane soluble fraction obtained from the CHCl3 crude extract. Through chromatographic methods and spectroscopic techniques, it was possible to isolate and identify ent-pimara-8(14), 15-dien-19-oic acid; 7-keto-ent-pimara-8(14),15-dien-19-oic acid; 6-acethyl-8-hydroxy-2,2-dimethylchromene; 7β-hydroxy-ent-pimara-8(14),15-dien-19-oic acid; ethyl 6,7-dihydroxycinammate, and rutin in the CH2Cl2 and AcOEt soluble fractions obtained from the CHCl3 and EtOH crude extracts. The CH2Cl2 soluble fractions obtained from the CHCl3 and EtOH crude extracts are active in vitro against the trypomastigote forms of Trypanossoma cruzi (Y strain)
author	VENEZIANI,RODRIGO C. S. DE OLIVEIRA,DIONÉIA C. R. ALBUQUERQUE,SÉRGIO CUNHA,WILSON R.
author_facet	VENEZIANI,RODRIGO C. S. DE OLIVEIRA,DIONÉIA C. R. ALBUQUERQUE,SÉRGIO CUNHA,WILSON R.
author_sort	VENEZIANI,RODRIGO C. S.
title	IN VITRO TRYPANOCIDAL ACTIVITY AND CHEMICAL CONSTITUENTS OF ASPILIA PLATYPHYLLA (BAKER) BLAKE
title_short	IN VITRO TRYPANOCIDAL ACTIVITY AND CHEMICAL CONSTITUENTS OF ASPILIA PLATYPHYLLA (BAKER) BLAKE
title_full	IN VITRO TRYPANOCIDAL ACTIVITY AND CHEMICAL CONSTITUENTS OF ASPILIA PLATYPHYLLA (BAKER) BLAKE
title_fullStr	IN VITRO TRYPANOCIDAL ACTIVITY AND CHEMICAL CONSTITUENTS OF ASPILIA PLATYPHYLLA (BAKER) BLAKE
title_full_unstemmed	IN VITRO TRYPANOCIDAL ACTIVITY AND CHEMICAL CONSTITUENTS OF ASPILIA PLATYPHYLLA (BAKER) BLAKE
title_sort	in vitro trypanocidal activity and chemical constituents of aspilia platyphylla (baker) blake
publisher	Sociedad Chilena de Química
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000100008
work_keys_str_mv	AT venezianirodrigocs invitrotrypanocidalactivityandchemicalconstituentsofaspiliaplatyphyllabakerblake AT deoliveiradioneiacr invitrotrypanocidalactivityandchemicalconstituentsofaspiliaplatyphyllabakerblake AT albuquerquesergio invitrotrypanocidalactivityandchemicalconstituentsofaspiliaplatyphyllabakerblake AT cunhawilsonr invitrotrypanocidalactivityandchemicalconstituentsofaspiliaplatyphyllabakerblake
_version_	1718445369171378176

IN VITRO TRYPANOCIDAL ACTIVITY AND CHEMICAL CONSTITUENTS OF ASPILIA PLATYPHYLLA (BAKER) BLAKE

Ejemplares similares