HYDROPHOBICALLY MODIFIED POLYELECTROLYTES AS POTENTIAL DRUGS RESERVOIRS OF N-ALKYL-NITROIMIDAZOLES

The solubilization of three commercial drugs (ornindazole, metronidazole and tinidazole) and model compounds (N-alkyl-2-methyl-4-nitroimidazoles) on aggregates formed by anionic polyelectrolytes, carrying alkyl side chains of different length, have been investigated in aqueous solution at pH 3.0, 7....

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Autores principales:	SALAMANCA,CONSTAIN H, BARRAZA,RAÚL G, ACEVEDO,BETSABÉ, OLEA,ANDRÉS F
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2007
Materias:	Polyelectrolyte maleic copolymers N-alkyl-nitroimidazoles partition drugs reservoirs
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000100014
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spelling	oai:scielo:S0717-970720070001000142007-05-07HYDROPHOBICALLY MODIFIED POLYELECTROLYTES AS POTENTIAL DRUGS RESERVOIRS OF N-ALKYL-NITROIMIDAZOLESSALAMANCA,CONSTAIN HBARRAZA,RAÚL GACEVEDO,BETSABÉOLEA,ANDRÉS F Polyelectrolyte maleic copolymers N-alkyl-nitroimidazoles partition drugs reservoirs The solubilization of three commercial drugs (ornindazole, metronidazole and tinidazole) and model compounds (N-alkyl-2-methyl-4-nitroimidazoles) on aggregates formed by anionic polyelectrolytes, carrying alkyl side chains of different length, have been investigated in aqueous solution at pH 3.0, 7.0 and 11.0. Potassium salts of poly(maleic acid-co-1-olefins), PA-nK2 with n ranging from 8 to 18, were used as micelle-forming polymers. The partition of these drugs between water and the hydrophobic microdomains provided by PA-nK2 was studied by the pseudo-phase model to determinate the distribution coefficient K S, and the standard free energy of transfer Δμºt. The results indicate that solubility of alkyl-nitroimidazoles on these polymer micelles depends moderately on the length of the alkyl chain, and therefore is mainly determined by the heterocyclic group. On the other hand, the solubilization of 1-hexyl-2-methyl-4-nitroimidazole increase with decreasing length of the side alkyl chain; i.e. K S follows the order PA-8K2 > PA-10K2 > PA-12K2 > PA-14K2 > PA-16K2 >PA-18K2info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.52 n.1 20072007-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000100014en10.4067/S0717-97072007000100014
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Polyelectrolyte maleic copolymers N-alkyl-nitroimidazoles partition drugs reservoirs
spellingShingle	Polyelectrolyte maleic copolymers N-alkyl-nitroimidazoles partition drugs reservoirs SALAMANCA,CONSTAIN H BARRAZA,RAÚL G ACEVEDO,BETSABÉ OLEA,ANDRÉS F HYDROPHOBICALLY MODIFIED POLYELECTROLYTES AS POTENTIAL DRUGS RESERVOIRS OF N-ALKYL-NITROIMIDAZOLES
description	The solubilization of three commercial drugs (ornindazole, metronidazole and tinidazole) and model compounds (N-alkyl-2-methyl-4-nitroimidazoles) on aggregates formed by anionic polyelectrolytes, carrying alkyl side chains of different length, have been investigated in aqueous solution at pH 3.0, 7.0 and 11.0. Potassium salts of poly(maleic acid-co-1-olefins), PA-nK2 with n ranging from 8 to 18, were used as micelle-forming polymers. The partition of these drugs between water and the hydrophobic microdomains provided by PA-nK2 was studied by the pseudo-phase model to determinate the distribution coefficient K S, and the standard free energy of transfer Δμºt. The results indicate that solubility of alkyl-nitroimidazoles on these polymer micelles depends moderately on the length of the alkyl chain, and therefore is mainly determined by the heterocyclic group. On the other hand, the solubilization of 1-hexyl-2-methyl-4-nitroimidazole increase with decreasing length of the side alkyl chain; i.e. K S follows the order PA-8K2 > PA-10K2 > PA-12K2 > PA-14K2 > PA-16K2 >PA-18K2
author	SALAMANCA,CONSTAIN H BARRAZA,RAÚL G ACEVEDO,BETSABÉ OLEA,ANDRÉS F
author_facet	SALAMANCA,CONSTAIN H BARRAZA,RAÚL G ACEVEDO,BETSABÉ OLEA,ANDRÉS F
author_sort	SALAMANCA,CONSTAIN H
title	HYDROPHOBICALLY MODIFIED POLYELECTROLYTES AS POTENTIAL DRUGS RESERVOIRS OF N-ALKYL-NITROIMIDAZOLES
title_short	HYDROPHOBICALLY MODIFIED POLYELECTROLYTES AS POTENTIAL DRUGS RESERVOIRS OF N-ALKYL-NITROIMIDAZOLES
title_full	HYDROPHOBICALLY MODIFIED POLYELECTROLYTES AS POTENTIAL DRUGS RESERVOIRS OF N-ALKYL-NITROIMIDAZOLES
title_fullStr	HYDROPHOBICALLY MODIFIED POLYELECTROLYTES AS POTENTIAL DRUGS RESERVOIRS OF N-ALKYL-NITROIMIDAZOLES
title_full_unstemmed	HYDROPHOBICALLY MODIFIED POLYELECTROLYTES AS POTENTIAL DRUGS RESERVOIRS OF N-ALKYL-NITROIMIDAZOLES
title_sort	hydrophobically modified polyelectrolytes as potential drugs reservoirs of n-alkyl-nitroimidazoles
publisher	Sociedad Chilena de Química
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000100014
work_keys_str_mv	AT salamancaconstainh hydrophobicallymodifiedpolyelectrolytesaspotentialdrugsreservoirsofnalkylnitroimidazoles AT barrazaraulg hydrophobicallymodifiedpolyelectrolytesaspotentialdrugsreservoirsofnalkylnitroimidazoles AT acevedobetsabe hydrophobicallymodifiedpolyelectrolytesaspotentialdrugsreservoirsofnalkylnitroimidazoles AT oleaandresf hydrophobicallymodifiedpolyelectrolytesaspotentialdrugsreservoirsofnalkylnitroimidazoles
_version_	1718445370320617472

HYDROPHOBICALLY MODIFIED POLYELECTROLYTES AS POTENTIAL DRUGS RESERVOIRS OF N-ALKYL-NITROIMIDAZOLES

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