SYNTHESIS, SPECTRAL CHARACTERIZATION AND DNA CLEAVAGE STUDY OF HETEROCYCLIC SCHIFF BASE METAL COMPLEXES

Four novel N2O2 type Schiff base metal complexes of Cu(II), Ni(II), Co(II) and Zn(II) have been synthesized from a new Schiff base ligand derived from 4-aminoantipyrine, salicylaldehyde and 2-amino-3-hydroxy- pyridine. The ligand and its complexes have been characterized on the basis of Elemental an...

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Autores principales:	RAMAN,N, JOHNSON RAJA,S, JOSEPH,J, DHAVEETHU RAJA,J
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2007
Materias:	4-aminoantipyrine salicylaldehyde 2-amino-3-hydroxypyridine calf thymus DNA antimicrobial activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000200004
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spelling	oai:scielo:S0717-970720070002000042007-09-13SYNTHESIS, SPECTRAL CHARACTERIZATION AND DNA CLEAVAGE STUDY OF HETEROCYCLIC SCHIFF BASE METAL COMPLEXESRAMAN,NJOHNSON RAJA,SJOSEPH,JDHAVEETHU RAJA,J 4-aminoantipyrine salicylaldehyde 2-amino-3-hydroxypyridine calf thymus DNA antimicrobial activity Four novel N2O2 type Schiff base metal complexes of Cu(II), Ni(II), Co(II) and Zn(II) have been synthesized from a new Schiff base ligand derived from 4-aminoantipyrine, salicylaldehyde and 2-amino-3-hydroxy- pyridine. The ligand and its complexes have been characterized on the basis of Elemental analyses, Magnetic susceptibility, FAB Mass, UV-Vis., IR, ¹H-NMR, ESR and CV spectral studies, as well as conductivity data. On the basis of spectral studies, a square-planar geometry for the complexes has been proposed. The ESR spectrum of Cu(II) complex was recorded at LNT and its salient features are reported. The in vitro antimicrobial activity of the investigated compounds was tested against the bacteria such as Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and fungi Candida albicans and Rhizopus stolonifer. The data indicate that most of the metal complexes have higher antimicrobial activity than the free ligand. DNA cleavage experiments performed on calf thymus DNA plasmids using metal complexes in the presence of H2O2 showed that all the complexes afford a pronounced DNA cleavageinfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.52 n.2 20072007-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000200004en10.4067/S0717-97072007000200004
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	4-aminoantipyrine salicylaldehyde 2-amino-3-hydroxypyridine calf thymus DNA antimicrobial activity
spellingShingle	4-aminoantipyrine salicylaldehyde 2-amino-3-hydroxypyridine calf thymus DNA antimicrobial activity RAMAN,N JOHNSON RAJA,S JOSEPH,J DHAVEETHU RAJA,J SYNTHESIS, SPECTRAL CHARACTERIZATION AND DNA CLEAVAGE STUDY OF HETEROCYCLIC SCHIFF BASE METAL COMPLEXES
description	Four novel N2O2 type Schiff base metal complexes of Cu(II), Ni(II), Co(II) and Zn(II) have been synthesized from a new Schiff base ligand derived from 4-aminoantipyrine, salicylaldehyde and 2-amino-3-hydroxy- pyridine. The ligand and its complexes have been characterized on the basis of Elemental analyses, Magnetic susceptibility, FAB Mass, UV-Vis., IR, ¹H-NMR, ESR and CV spectral studies, as well as conductivity data. On the basis of spectral studies, a square-planar geometry for the complexes has been proposed. The ESR spectrum of Cu(II) complex was recorded at LNT and its salient features are reported. The in vitro antimicrobial activity of the investigated compounds was tested against the bacteria such as Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and fungi Candida albicans and Rhizopus stolonifer. The data indicate that most of the metal complexes have higher antimicrobial activity than the free ligand. DNA cleavage experiments performed on calf thymus DNA plasmids using metal complexes in the presence of H2O2 showed that all the complexes afford a pronounced DNA cleavage
author	RAMAN,N JOHNSON RAJA,S JOSEPH,J DHAVEETHU RAJA,J
author_facet	RAMAN,N JOHNSON RAJA,S JOSEPH,J DHAVEETHU RAJA,J
author_sort	RAMAN,N
title	SYNTHESIS, SPECTRAL CHARACTERIZATION AND DNA CLEAVAGE STUDY OF HETEROCYCLIC SCHIFF BASE METAL COMPLEXES
title_short	SYNTHESIS, SPECTRAL CHARACTERIZATION AND DNA CLEAVAGE STUDY OF HETEROCYCLIC SCHIFF BASE METAL COMPLEXES
title_full	SYNTHESIS, SPECTRAL CHARACTERIZATION AND DNA CLEAVAGE STUDY OF HETEROCYCLIC SCHIFF BASE METAL COMPLEXES
title_fullStr	SYNTHESIS, SPECTRAL CHARACTERIZATION AND DNA CLEAVAGE STUDY OF HETEROCYCLIC SCHIFF BASE METAL COMPLEXES
title_full_unstemmed	SYNTHESIS, SPECTRAL CHARACTERIZATION AND DNA CLEAVAGE STUDY OF HETEROCYCLIC SCHIFF BASE METAL COMPLEXES
title_sort	synthesis, spectral characterization and dna cleavage study of heterocyclic schiff base metal complexes
publisher	Sociedad Chilena de Química
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000200004
work_keys_str_mv	AT ramann synthesisspectralcharacterizationanddnacleavagestudyofheterocyclicschiffbasemetalcomplexes AT johnsonrajas synthesisspectralcharacterizationanddnacleavagestudyofheterocyclicschiffbasemetalcomplexes AT josephj synthesisspectralcharacterizationanddnacleavagestudyofheterocyclicschiffbasemetalcomplexes AT dhaveethurajaj synthesisspectralcharacterizationanddnacleavagestudyofheterocyclicschiffbasemetalcomplexes
_version_	1718445371407990784

SYNTHESIS, SPECTRAL CHARACTERIZATION AND DNA CLEAVAGE STUDY OF HETEROCYCLIC SCHIFF BASE METAL COMPLEXES

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