SYNTHESIS OF NOVEL PYRAZOLE, COUMARIN AND PYRIDAZINE DERIVATIVES EVALUATED AS POTENTIAL ANTIMICROBIAL AND ANTIFUNGAL AGENTS
The reaction of cyanoacetylhydrazine with ω-bromoacetophenone gave the N-[2-bromo-1-phenylethylidene]-2-isocyanoacetohydrazide (3). The latter compound underwent ready cyclization when treated with potassium cyanide to give the 1-(isocyanoacetyl)-3-phenyl-1H-pyrazol-5-amine (6). Compound 6...
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| Autores principales: | , |
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| Lenguaje: | English |
| Publicado: |
Sociedad Chilena de Química
2007
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| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000200006 |
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| Sumario: | The reaction of cyanoacetylhydrazine with ω-bromoacetophenone gave the N-[2-bromo-1-phenylethylidene]-2-isocyanoacetohydrazide (3). The latter compound underwent ready cyclization when treated with potassium cyanide to give the 1-(isocyanoacetyl)-3-phenyl-1H-pyrazol-5-amine (6). Compound 6 underwent a series of heterocyclization to give either coumarin, pyridazine, 1,2,4-triazine or thiophene derivatives. The antimicrobial and antifungal activities of the newly synthesized products were measured, using two Gram-negative (Escherichia coli and Pseudomonas aeruginosa), two Gram-positive bacteria (Bacillus subtilis and Bacillus cereus) and the antifungal activity using Candida albicans |
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