SYNTHESIS OF NOVEL PYRAZOLE, COUMARIN AND PYRIDAZINE DERIVATIVES EVALUATED AS POTENTIAL ANTIMICROBIAL AND ANTIFUNGAL AGENTS

SYNTHESIS OF NOVEL PYRAZOLE, COUMARIN AND PYRIDAZINE DERIVATIVES EVALUATED AS POTENTIAL ANTIMICROBIAL AND ANTIFUNGAL AGENTS

The reaction of cyanoacetylhydrazine with ω-bromoacetophenone gave the N’-[2-bromo-1-phenylethylidene]-2-isocyanoacetohydrazide (3). The latter compound underwent ready cyclization when treated with potassium cyanide to give the 1-(isocyanoacetyl)-3-phenyl-1H-pyrazol-5-amine (6). Compound 6...

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Autores principales: WARDAKHAN,WAGNAT W, LOUCA,NADIA A
Lenguaje:English
Publicado: Sociedad Chilena de Química 2007
Materias:
Cyanoacetylhydrazine
Pyrazole
Coumarin
Pyridazine
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000200006
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spelling oai:scielo:S0717-970720070002000062007-09-13SYNTHESIS OF NOVEL PYRAZOLE, COUMARIN AND PYRIDAZINE DERIVATIVES EVALUATED AS POTENTIAL ANTIMICROBIAL AND ANTIFUNGAL AGENTSWARDAKHAN,WAGNAT WLOUCA,NADIA A Cyanoacetylhydrazine Pyrazole Coumarin Pyridazine The reaction of cyanoacetylhydrazine with ω-bromoacetophenone gave the N’-[2-bromo-1-phenylethylidene]-2-isocyanoacetohydrazide (3). The latter compound underwent ready cyclization when treated with potassium cyanide to give the 1-(isocyanoacetyl)-3-phenyl-1H-pyrazol-5-amine (6). Compound 6 underwent a series of heterocyclization to give either coumarin, pyridazine, 1,2,4-triazine or thiophene derivatives. The antimicrobial and antifungal activities of the newly synthesized products were measured, using two Gram-negative (Escherichia coli and Pseudomonas aeruginosa), two Gram-positive bacteria (Bacillus subtilis and Bacillus cereus) and the antifungal activity using Candida albicansinfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.52 n.2 20072007-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000200006en10.4067/S0717-97072007000200006
institution Scielo Chile
collection Scielo Chile
language English
topic Cyanoacetylhydrazine
Pyrazole
Coumarin
Pyridazine
spellingShingle Cyanoacetylhydrazine
Pyrazole
Coumarin
Pyridazine
WARDAKHAN,WAGNAT W
LOUCA,NADIA A
SYNTHESIS OF NOVEL PYRAZOLE, COUMARIN AND PYRIDAZINE DERIVATIVES EVALUATED AS POTENTIAL ANTIMICROBIAL AND ANTIFUNGAL AGENTS
description The reaction of cyanoacetylhydrazine with ω-bromoacetophenone gave the N’-[2-bromo-1-phenylethylidene]-2-isocyanoacetohydrazide (3). The latter compound underwent ready cyclization when treated with potassium cyanide to give the 1-(isocyanoacetyl)-3-phenyl-1H-pyrazol-5-amine (6). Compound 6 underwent a series of heterocyclization to give either coumarin, pyridazine, 1,2,4-triazine or thiophene derivatives. The antimicrobial and antifungal activities of the newly synthesized products were measured, using two Gram-negative (Escherichia coli and Pseudomonas aeruginosa), two Gram-positive bacteria (Bacillus subtilis and Bacillus cereus) and the antifungal activity using Candida albicans
author WARDAKHAN,WAGNAT W
LOUCA,NADIA A
author_facet WARDAKHAN,WAGNAT W
LOUCA,NADIA A
author_sort WARDAKHAN,WAGNAT W
title SYNTHESIS OF NOVEL PYRAZOLE, COUMARIN AND PYRIDAZINE DERIVATIVES EVALUATED AS POTENTIAL ANTIMICROBIAL AND ANTIFUNGAL AGENTS
title_short SYNTHESIS OF NOVEL PYRAZOLE, COUMARIN AND PYRIDAZINE DERIVATIVES EVALUATED AS POTENTIAL ANTIMICROBIAL AND ANTIFUNGAL AGENTS
title_full SYNTHESIS OF NOVEL PYRAZOLE, COUMARIN AND PYRIDAZINE DERIVATIVES EVALUATED AS POTENTIAL ANTIMICROBIAL AND ANTIFUNGAL AGENTS
title_fullStr SYNTHESIS OF NOVEL PYRAZOLE, COUMARIN AND PYRIDAZINE DERIVATIVES EVALUATED AS POTENTIAL ANTIMICROBIAL AND ANTIFUNGAL AGENTS
title_full_unstemmed SYNTHESIS OF NOVEL PYRAZOLE, COUMARIN AND PYRIDAZINE DERIVATIVES EVALUATED AS POTENTIAL ANTIMICROBIAL AND ANTIFUNGAL AGENTS
title_sort synthesis of novel pyrazole, coumarin and pyridazine derivatives evaluated as potential antimicrobial and antifungal agents
publisher Sociedad Chilena de Química
publishDate 2007
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000200006
work_keys_str_mv AT wardakhanwagnatw synthesisofnovelpyrazolecoumarinandpyridazinederivativesevaluatedaspotentialantimicrobialandantifungalagents
AT loucanadiaa synthesisofnovelpyrazolecoumarinandpyridazinederivativesevaluatedaspotentialantimicrobialandantifungalagents
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