HPLC DETERMINATION OF EZETIMIBE AND SIMVASTATIN IN PHARMACEUTICAL FORMULATIONS

Asimple, precise and sensitive reverse-phase high performance liquid chromatographic method was developed and validated for the simultaneous determination of ezetimibe and simvastatin in pharmaceutical formulations. Chromatographic separation was performed on a Merck Cl 8 columnata wavelength of 240...

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Autores principales:	ASHFAQ,MUHAMMAD, ULLAHKHAN,ISLAM, SHANAZ QUTAB,SYED, NAEEMRAZZAQ,SYED
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2007
Materias:	HPLC acetonitrile isocratic ezetimibe simvastatin
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000300005
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spelling	oai:scielo:S0717-970720070003000052007-11-29HPLC DETERMINATION OF EZETIMIBE AND SIMVASTATIN IN PHARMACEUTICAL FORMULATIONSASHFAQ,MUHAMMADULLAHKHAN,ISLAMSHANAZ QUTAB,SYEDNAEEMRAZZAQ,SYED HPLC acetonitrile isocratic ezetimibe simvastatin Asimple, precise and sensitive reverse-phase high performance liquid chromatographic method was developed and validated for the simultaneous determination of ezetimibe and simvastatin in pharmaceutical formulations. Chromatographic separation was performed on a Merck Cl 8 columnata wavelength of 240 nm using a mixture of 0.1M ammonium acetate buffer pH 5.0 and acetonitrile in the ratio of (30:70, v/v). The method results in excellent separation with good resolution between the two analytes. The within day variation was between 0.28 and 1.10 % and between day variation was between 0.56 and 1.32 %. The recovery was greater than 99.12 % with RSD less than 1.38 %. The method was validated according to ICH guidelines by performing linearity, accuracy, precision, limits of quantitation and selectivity. The results show mat the method is suitable for its intended useinfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.52 n.3 20072007-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000300005en10.4067/S0717-97072007000300005
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	HPLC acetonitrile isocratic ezetimibe simvastatin
spellingShingle	HPLC acetonitrile isocratic ezetimibe simvastatin ASHFAQ,MUHAMMAD ULLAHKHAN,ISLAM SHANAZ QUTAB,SYED NAEEMRAZZAQ,SYED HPLC DETERMINATION OF EZETIMIBE AND SIMVASTATIN IN PHARMACEUTICAL FORMULATIONS
description	Asimple, precise and sensitive reverse-phase high performance liquid chromatographic method was developed and validated for the simultaneous determination of ezetimibe and simvastatin in pharmaceutical formulations. Chromatographic separation was performed on a Merck Cl 8 columnata wavelength of 240 nm using a mixture of 0.1M ammonium acetate buffer pH 5.0 and acetonitrile in the ratio of (30:70, v/v). The method results in excellent separation with good resolution between the two analytes. The within day variation was between 0.28 and 1.10 % and between day variation was between 0.56 and 1.32 %. The recovery was greater than 99.12 % with RSD less than 1.38 %. The method was validated according to ICH guidelines by performing linearity, accuracy, precision, limits of quantitation and selectivity. The results show mat the method is suitable for its intended use
author	ASHFAQ,MUHAMMAD ULLAHKHAN,ISLAM SHANAZ QUTAB,SYED NAEEMRAZZAQ,SYED
author_facet	ASHFAQ,MUHAMMAD ULLAHKHAN,ISLAM SHANAZ QUTAB,SYED NAEEMRAZZAQ,SYED
author_sort	ASHFAQ,MUHAMMAD
title	HPLC DETERMINATION OF EZETIMIBE AND SIMVASTATIN IN PHARMACEUTICAL FORMULATIONS
title_short	HPLC DETERMINATION OF EZETIMIBE AND SIMVASTATIN IN PHARMACEUTICAL FORMULATIONS
title_full	HPLC DETERMINATION OF EZETIMIBE AND SIMVASTATIN IN PHARMACEUTICAL FORMULATIONS
title_fullStr	HPLC DETERMINATION OF EZETIMIBE AND SIMVASTATIN IN PHARMACEUTICAL FORMULATIONS
title_full_unstemmed	HPLC DETERMINATION OF EZETIMIBE AND SIMVASTATIN IN PHARMACEUTICAL FORMULATIONS
title_sort	hplc determination of ezetimibe and simvastatin in pharmaceutical formulations
publisher	Sociedad Chilena de Química
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000300005
work_keys_str_mv	AT ashfaqmuhammad hplcdeterminationofezetimibeandsimvastatininpharmaceuticalformulations AT ullahkhanislam hplcdeterminationofezetimibeandsimvastatininpharmaceuticalformulations AT shanazqutabsyed hplcdeterminationofezetimibeandsimvastatininpharmaceuticalformulations AT naeemrazzaqsyed hplcdeterminationofezetimibeandsimvastatininpharmaceuticalformulations
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HPLC DETERMINATION OF EZETIMIBE AND SIMVASTATIN IN PHARMACEUTICAL FORMULATIONS

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