REDOX PROPERTIES OF RUTHENIUM COMPLEX WITH CATECHOL ARE INVOLVED IN TOXICITY TO GLIAL CELLS

Since the biological activity of [RuIII(NH3)4(catechol)]+ has never been tested, its cytotoxicity to glial cells was assayed and correlated with its redox properties. Coordinated catechol oxidizes faster than catechol in the presence of oxygen, but controlled potential electrolysis showed that its o...

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Autores principales:	WAGNER L. C,ALMEIDA, VÍTOR,DANIELA N., PEREIRA,MARCO R. G, DESÁ,DENISE S., ALVAREZ,LISANDRO D. G, PINHEIRO,ALEXANDRE M, COSTA,SILVIA L., COSTA,MARIA F. D, ROCHA,ZÊNIS N. DA, EL-BACHÁ,RAMON S
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2007
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000300010
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spelling	oai:scielo:S0717-970720070003000102007-11-29REDOX PROPERTIES OF RUTHENIUM COMPLEX WITH CATECHOL ARE INVOLVED IN TOXICITY TO GLIAL CELLSWAGNER L. C,ALMEIDAVÍTOR,DANIELA N.PEREIRA,MARCO R. GDESÁ,DENISE S.ALVAREZ,LISANDRO D. GPINHEIRO,ALEXANDRE MCOSTA,SILVIA L.COSTA,MARIA F. DROCHA,ZÊNIS N. DAEL-BACHÁ,RAMON SSince the biological activity of [RuIII(NH3)4(catechol)]+ has never been tested, its cytotoxicity to glial cells was assayed and correlated with its redox properties. Coordinated catechol oxidizes faster than catechol in the presence of oxygen, but controlled potential electrolysis showed that its oxidation involves only one-electron. However, the oxidation of the free ligand by oxygen involves two electrons, which could generate more reactive oxygen species. Indeed, catechol was more cytotoxic than [RuIII(NH3)4(catechol)]+ complex to human glioblastoma GL-15 cells and also to rat astrocytes. [RuIII(NH3)4(catechol)]+-induced cytotoxicity was related to the generation of reactive oxygen species and [RuC1(NH3)5]2+. However, other mechanisms should be involved since antioxidant enzymes and deferoxamine only partially protected GL-15 cellsinfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.52 n.3 20072007-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000300010en10.4067/S0717-97072007000300010
institution	Scielo Chile
collection	Scielo Chile
language	English
description	Since the biological activity of [RuIII(NH3)4(catechol)]+ has never been tested, its cytotoxicity to glial cells was assayed and correlated with its redox properties. Coordinated catechol oxidizes faster than catechol in the presence of oxygen, but controlled potential electrolysis showed that its oxidation involves only one-electron. However, the oxidation of the free ligand by oxygen involves two electrons, which could generate more reactive oxygen species. Indeed, catechol was more cytotoxic than [RuIII(NH3)4(catechol)]+ complex to human glioblastoma GL-15 cells and also to rat astrocytes. [RuIII(NH3)4(catechol)]+-induced cytotoxicity was related to the generation of reactive oxygen species and [RuC1(NH3)5]2+. However, other mechanisms should be involved since antioxidant enzymes and deferoxamine only partially protected GL-15 cells
author	WAGNER L. C,ALMEIDA VÍTOR,DANIELA N. PEREIRA,MARCO R. G DESÁ,DENISE S. ALVAREZ,LISANDRO D. G PINHEIRO,ALEXANDRE M COSTA,SILVIA L. COSTA,MARIA F. D ROCHA,ZÊNIS N. DA EL-BACHÁ,RAMON S
spellingShingle	WAGNER L. C,ALMEIDA VÍTOR,DANIELA N. PEREIRA,MARCO R. G DESÁ,DENISE S. ALVAREZ,LISANDRO D. G PINHEIRO,ALEXANDRE M COSTA,SILVIA L. COSTA,MARIA F. D ROCHA,ZÊNIS N. DA EL-BACHÁ,RAMON S REDOX PROPERTIES OF RUTHENIUM COMPLEX WITH CATECHOL ARE INVOLVED IN TOXICITY TO GLIAL CELLS
author_facet	WAGNER L. C,ALMEIDA VÍTOR,DANIELA N. PEREIRA,MARCO R. G DESÁ,DENISE S. ALVAREZ,LISANDRO D. G PINHEIRO,ALEXANDRE M COSTA,SILVIA L. COSTA,MARIA F. D ROCHA,ZÊNIS N. DA EL-BACHÁ,RAMON S
author_sort	WAGNER L. C,ALMEIDA
title	REDOX PROPERTIES OF RUTHENIUM COMPLEX WITH CATECHOL ARE INVOLVED IN TOXICITY TO GLIAL CELLS
title_short	REDOX PROPERTIES OF RUTHENIUM COMPLEX WITH CATECHOL ARE INVOLVED IN TOXICITY TO GLIAL CELLS
title_full	REDOX PROPERTIES OF RUTHENIUM COMPLEX WITH CATECHOL ARE INVOLVED IN TOXICITY TO GLIAL CELLS
title_fullStr	REDOX PROPERTIES OF RUTHENIUM COMPLEX WITH CATECHOL ARE INVOLVED IN TOXICITY TO GLIAL CELLS
title_full_unstemmed	REDOX PROPERTIES OF RUTHENIUM COMPLEX WITH CATECHOL ARE INVOLVED IN TOXICITY TO GLIAL CELLS
title_sort	redox properties of ruthenium complex with catechol are involved in toxicity to glial cells
publisher	Sociedad Chilena de Química
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000300010
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REDOX PROPERTIES OF RUTHENIUM COMPLEX WITH CATECHOL ARE INVOLVED IN TOXICITY TO GLIAL CELLS

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