1-BENZOYL-2-(2-NITROPHENYL)-1H-BENZIMIDAZOLE DERIVATIVES: A NOVEL APPROACH TO THE DEVELOPMENT OF NEW HIV-1 REVERSE TRANSCRIPTASE INHIBITORS

1-BENZOYL-2-(2-NITROPHENYL)-1H-BENZIMIDAZOLE DERIVATIVES: A NOVEL APPROACH TO THE DEVELOPMENT OF NEW HIV-1 REVERSE TRANSCRIPTASE INHIBITORS

A novel approach to the development of a new class of HIV-1 RT inhibitors is reported. The 1-benzoyl-2-aryl-1H-benzimidazole series was designed as a combination of two previously reported active scaffolds, the benzimidazole and benzoyl moieties. The active compounds of the series effectively blocke...

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Main Authors: VÁSQUEZ,DAVID, LAGOS,CARLOS F, MELLA-RAIPÁN,JAIME, GONZÁLEZ,LUIS, EBENSPERGER,ROBERTO, ALVAREZ-FIGUEROA,M. JAVIERA, SÁEZ,EDMUNDO, PESSOA-MAHANA,HERNÁN, ARAYA-SECCHP,RAÚL, GONZÁLEZ-WONG,ANGEL, PÉREZ-ACLE,TOMÁS, PESSOA-MAHANA,C. DAVID
Language:English
Published: Sociedad Chilena de Química 2007
Subjects:
NNRTIs
HIV-1 RT
molecular modeling
benzoylbenzimidazole derivatives
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000400002
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