REGIOSELECTIVE SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF O-ALKYLATED PHYSCION'S DERIVATIVES

REGIOSELECTIVE SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF O-ALKYLATED PHYSCION'S DERIVATIVES

Regioselectivity in the reaction of microwave promoted O-alkylation of physcion in the presence of montmorillonite clay K-10 was discussed. The mechanism of formation of corresponding anions of physcion was investigated using semiempirical molecular-orbital methods. The results of antibacterial and...

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Autores principales: MANOJLOVIC,N, MARKOVIC,Z, DURIC,M
Lenguaje:English
Publicado: Sociedad Chilena de Química 2007
Materias:
physcion
O-alkylation
regio selective synthesis
antimicrobial activity
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000400014
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spelling oai:scielo:S0717-970720070004000142008-04-30REGIOSELECTIVE SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF O-ALKYLATED PHYSCION'S DERIVATIVESMANOJLOVIC,NMARKOVIC,ZDURIC,M physcion O-alkylation regio selective synthesis antimicrobial activity Regioselectivity in the reaction of microwave promoted O-alkylation of physcion in the presence of montmorillonite clay K-10 was discussed. The mechanism of formation of corresponding anions of physcion was investigated using semiempirical molecular-orbital methods. The results of antibacterial and antifungal activity of the obtained derivatives showed that the introduction of different substituents (OCF£3, OCH2C(CH3)=CH2, OCH2CH2CH3 and OCH2C6H5), at the C-1 and C-8 atoms led to a remarkable change in their antimicrobial activityinfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.52 n.4 20072007-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000400014en10.4067/S0717-97072007000400014
institution Scielo Chile
collection Scielo Chile
language English
topic physcion
O-alkylation
regio selective synthesis
antimicrobial activity
spellingShingle physcion
O-alkylation
regio selective synthesis
antimicrobial activity
MANOJLOVIC,N
MARKOVIC,Z
DURIC,M
REGIOSELECTIVE SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF O-ALKYLATED PHYSCION'S DERIVATIVES
description Regioselectivity in the reaction of microwave promoted O-alkylation of physcion in the presence of montmorillonite clay K-10 was discussed. The mechanism of formation of corresponding anions of physcion was investigated using semiempirical molecular-orbital methods. The results of antibacterial and antifungal activity of the obtained derivatives showed that the introduction of different substituents (OCF£3, OCH2C(CH3)=CH2, OCH2CH2CH3 and OCH2C6H5), at the C-1 and C-8 atoms led to a remarkable change in their antimicrobial activity
author MANOJLOVIC,N
MARKOVIC,Z
DURIC,M
author_facet MANOJLOVIC,N
MARKOVIC,Z
DURIC,M
author_sort MANOJLOVIC,N
title REGIOSELECTIVE SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF O-ALKYLATED PHYSCION'S DERIVATIVES
title_short REGIOSELECTIVE SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF O-ALKYLATED PHYSCION'S DERIVATIVES
title_full REGIOSELECTIVE SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF O-ALKYLATED PHYSCION'S DERIVATIVES
title_fullStr REGIOSELECTIVE SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF O-ALKYLATED PHYSCION'S DERIVATIVES
title_full_unstemmed REGIOSELECTIVE SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF O-ALKYLATED PHYSCION'S DERIVATIVES
title_sort regioselective synthesis and antimicrobial activity of o-alkylated physcion's derivatives
publisher Sociedad Chilena de Química
publishDate 2007
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000400014
work_keys_str_mv AT manojlovicn regioselectivesynthesisandantimicrobialactivityofoalkylatedphyscionsderivatives
AT markovicz regioselectivesynthesisandantimicrobialactivityofoalkylatedphyscionsderivatives
AT duricm regioselectivesynthesisandantimicrobialactivityofoalkylatedphyscionsderivatives
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