DNA CLEAVAGE AND ANTIMICROBIAL ACTIVITY STUDIES ON TRANSITION METAL(II) COMPLEXES OF 4-AMINOANTIPYRINE DERIVATIVE

Anew series of transition metal complexes of Cu(II), Ni(II), Co(II) and Zn(II) have been synthesized from the Schiff base (L) derived from 4-aminoantipyrine, salicylaldehyde and o-phenylenediamine. The structural features have been arrived from their elemental analyses, magnetic susceptibility, mola...

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Autores principales:	RAMAN,N, THALAMUTHU,S, DHAVEETHURAJA,J, NEELAKANDAN,M.A., BANERJEE,SHARMILA
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2008
Materias:	Schiff base 4-aminoantipyrine CT-DNA nuclease activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000100025
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spelling	oai:scielo:S0717-970720080001000252008-07-03DNA CLEAVAGE AND ANTIMICROBIAL ACTIVITY STUDIES ON TRANSITION METAL(II) COMPLEXES OF 4-AMINOANTIPYRINE DERIVATIVERAMAN,NTHALAMUTHU,SDHAVEETHURAJA,JNEELAKANDAN,M.A.BANERJEE,SHARMILA Schiff base 4-aminoantipyrine CT-DNA nuclease activity Anew series of transition metal complexes of Cu(II), Ni(II), Co(II) and Zn(II) have been synthesized from the Schiff base (L) derived from 4-aminoantipyrine, salicylaldehyde and o-phenylenediamine. The structural features have been arrived from their elemental analyses, magnetic susceptibility, molar conductivity, FAB-mass, IR, UV-Vis., 'H NMR and ESR spectral studies. The data show that the complexes have composition of ML type. The UV-Vis., magnetic susceptibility and ESR spectral data of the complexes suggest a square-planar geometry around the central metal ion. The antimicrobial activities of the metal chelates against the bacteria Salmonella typhi, Pseudomonas aeruginosa, Bacillus subtilis, Escherichia coli and fungi Aspergillus niger, Aspergillus flavus and Rhizoctonia bataicola have been carried out. A comparative study of MIC values of the Schiff base and its metal complexes indicates that the metal complexes exhibit higher antibacterial activity than the free ligand. The nuclease activity of the above metal complexes shows only the copper complex cleaves DNAinfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.53 n.1 20082008-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000100025en10.4067/S0717-97072008000100025
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Schiff base 4-aminoantipyrine CT-DNA nuclease activity
spellingShingle	Schiff base 4-aminoantipyrine CT-DNA nuclease activity RAMAN,N THALAMUTHU,S DHAVEETHURAJA,J NEELAKANDAN,M.A. BANERJEE,SHARMILA DNA CLEAVAGE AND ANTIMICROBIAL ACTIVITY STUDIES ON TRANSITION METAL(II) COMPLEXES OF 4-AMINOANTIPYRINE DERIVATIVE
description	Anew series of transition metal complexes of Cu(II), Ni(II), Co(II) and Zn(II) have been synthesized from the Schiff base (L) derived from 4-aminoantipyrine, salicylaldehyde and o-phenylenediamine. The structural features have been arrived from their elemental analyses, magnetic susceptibility, molar conductivity, FAB-mass, IR, UV-Vis., 'H NMR and ESR spectral studies. The data show that the complexes have composition of ML type. The UV-Vis., magnetic susceptibility and ESR spectral data of the complexes suggest a square-planar geometry around the central metal ion. The antimicrobial activities of the metal chelates against the bacteria Salmonella typhi, Pseudomonas aeruginosa, Bacillus subtilis, Escherichia coli and fungi Aspergillus niger, Aspergillus flavus and Rhizoctonia bataicola have been carried out. A comparative study of MIC values of the Schiff base and its metal complexes indicates that the metal complexes exhibit higher antibacterial activity than the free ligand. The nuclease activity of the above metal complexes shows only the copper complex cleaves DNA
author	RAMAN,N THALAMUTHU,S DHAVEETHURAJA,J NEELAKANDAN,M.A. BANERJEE,SHARMILA
author_facet	RAMAN,N THALAMUTHU,S DHAVEETHURAJA,J NEELAKANDAN,M.A. BANERJEE,SHARMILA
author_sort	RAMAN,N
title	DNA CLEAVAGE AND ANTIMICROBIAL ACTIVITY STUDIES ON TRANSITION METAL(II) COMPLEXES OF 4-AMINOANTIPYRINE DERIVATIVE
title_short	DNA CLEAVAGE AND ANTIMICROBIAL ACTIVITY STUDIES ON TRANSITION METAL(II) COMPLEXES OF 4-AMINOANTIPYRINE DERIVATIVE
title_full	DNA CLEAVAGE AND ANTIMICROBIAL ACTIVITY STUDIES ON TRANSITION METAL(II) COMPLEXES OF 4-AMINOANTIPYRINE DERIVATIVE
title_fullStr	DNA CLEAVAGE AND ANTIMICROBIAL ACTIVITY STUDIES ON TRANSITION METAL(II) COMPLEXES OF 4-AMINOANTIPYRINE DERIVATIVE
title_full_unstemmed	DNA CLEAVAGE AND ANTIMICROBIAL ACTIVITY STUDIES ON TRANSITION METAL(II) COMPLEXES OF 4-AMINOANTIPYRINE DERIVATIVE
title_sort	dna cleavage and antimicrobial activity studies on transition metal(ii) complexes of 4-aminoantipyrine derivative
publisher	Sociedad Chilena de Química
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000100025
work_keys_str_mv	AT ramann dnacleavageandantimicrobialactivitystudiesontransitionmetaliicomplexesof4aminoantipyrinederivative AT thalamuthus dnacleavageandantimicrobialactivitystudiesontransitionmetaliicomplexesof4aminoantipyrinederivative AT dhaveethurajaj dnacleavageandantimicrobialactivitystudiesontransitionmetaliicomplexesof4aminoantipyrinederivative AT neelakandanma dnacleavageandantimicrobialactivitystudiesontransitionmetaliicomplexesof4aminoantipyrinederivative AT banerjeesharmila dnacleavageandantimicrobialactivitystudiesontransitionmetaliicomplexesof4aminoantipyrinederivative
_version_	1718445384721760256

DNA CLEAVAGE AND ANTIMICROBIAL ACTIVITY STUDIES ON TRANSITION METAL(II) COMPLEXES OF 4-AMINOANTIPYRINE DERIVATIVE

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