TEMPLATE SYNTHESIS OF NOVEL 14-MEMBERED TETRAAZAMACROCYCLIC TRANSITION METAL COMPLEXES: DNA CLEAVAGE AND ANTIMICROBIAL STUDIES

A new series of 14 membered tetraazamacrocyclic complexes of type [ML]X2, where M=Ni(II), Co(II), Cu(II), Zn(II), Hg(II), VO(IV), Cd(II) and Mn(II); X2= 2C1- S0(4)2- have been synthesized by incorporating an N4 donor site via. the témplate condensation of o-phenylenediamine, formaldehyde, p-anisidin...

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Autores principales:	RAMAN,N, DHAVEETHU RAJA,J, SAKTHIVEL,A
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2008
Materias:	o-phenylenediamine p-anisidine CT DNA antimicrobial activity nuclease activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000300003
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spelling	oai:scielo:S0717-970720080003000032008-10-23TEMPLATE SYNTHESIS OF NOVEL 14-MEMBERED TETRAAZAMACROCYCLIC TRANSITION METAL COMPLEXES: DNA CLEAVAGE AND ANTIMICROBIAL STUDIESRAMAN,NDHAVEETHU RAJA,JSAKTHIVEL,A o-phenylenediamine p-anisidine CT DNA antimicrobial activity nuclease activity A new series of 14 membered tetraazamacrocyclic complexes of type [ML]X2, where M=Ni(II), Co(II), Cu(II), Zn(II), Hg(II), VO(IV), Cd(II) and Mn(II); X2= 2C1- S0(4)2- have been synthesized by incorporating an N4 donor site via. the témplate condensation of o-phenylenediamine, formaldehyde, p-anisidine and metal salt. The structural features of the complexes have been confirmed by spectral and analytical data. From the data, a square-planar geometry around the central metal ion has been suggested except VO(IV) complex which has square-pyramidal geometry. The antimicrobial screening data show good results. From the nuclease activity of the abo ve metal complexes, it is inferred that only the copper and nickel complexes cleave DNA through redox chemistryinfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.53 n.3 20082008-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000300003en10.4067/S0717-97072008000300003
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	o-phenylenediamine p-anisidine CT DNA antimicrobial activity nuclease activity
spellingShingle	o-phenylenediamine p-anisidine CT DNA antimicrobial activity nuclease activity RAMAN,N DHAVEETHU RAJA,J SAKTHIVEL,A TEMPLATE SYNTHESIS OF NOVEL 14-MEMBERED TETRAAZAMACROCYCLIC TRANSITION METAL COMPLEXES: DNA CLEAVAGE AND ANTIMICROBIAL STUDIES
description	A new series of 14 membered tetraazamacrocyclic complexes of type [ML]X2, where M=Ni(II), Co(II), Cu(II), Zn(II), Hg(II), VO(IV), Cd(II) and Mn(II); X2= 2C1- S0(4)2- have been synthesized by incorporating an N4 donor site via. the témplate condensation of o-phenylenediamine, formaldehyde, p-anisidine and metal salt. The structural features of the complexes have been confirmed by spectral and analytical data. From the data, a square-planar geometry around the central metal ion has been suggested except VO(IV) complex which has square-pyramidal geometry. The antimicrobial screening data show good results. From the nuclease activity of the abo ve metal complexes, it is inferred that only the copper and nickel complexes cleave DNA through redox chemistry
author	RAMAN,N DHAVEETHU RAJA,J SAKTHIVEL,A
author_facet	RAMAN,N DHAVEETHU RAJA,J SAKTHIVEL,A
author_sort	RAMAN,N
title	TEMPLATE SYNTHESIS OF NOVEL 14-MEMBERED TETRAAZAMACROCYCLIC TRANSITION METAL COMPLEXES: DNA CLEAVAGE AND ANTIMICROBIAL STUDIES
title_short	TEMPLATE SYNTHESIS OF NOVEL 14-MEMBERED TETRAAZAMACROCYCLIC TRANSITION METAL COMPLEXES: DNA CLEAVAGE AND ANTIMICROBIAL STUDIES
title_full	TEMPLATE SYNTHESIS OF NOVEL 14-MEMBERED TETRAAZAMACROCYCLIC TRANSITION METAL COMPLEXES: DNA CLEAVAGE AND ANTIMICROBIAL STUDIES
title_fullStr	TEMPLATE SYNTHESIS OF NOVEL 14-MEMBERED TETRAAZAMACROCYCLIC TRANSITION METAL COMPLEXES: DNA CLEAVAGE AND ANTIMICROBIAL STUDIES
title_full_unstemmed	TEMPLATE SYNTHESIS OF NOVEL 14-MEMBERED TETRAAZAMACROCYCLIC TRANSITION METAL COMPLEXES: DNA CLEAVAGE AND ANTIMICROBIAL STUDIES
title_sort	template synthesis of novel 14-membered tetraazamacrocyclic transition metal complexes: dna cleavage and antimicrobial studies
publisher	Sociedad Chilena de Química
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000300003
work_keys_str_mv	AT ramann templatesynthesisofnovel14memberedtetraazamacrocyclictransitionmetalcomplexesdnacleavageandantimicrobialstudies AT dhaveethurajaj templatesynthesisofnovel14memberedtetraazamacrocyclictransitionmetalcomplexesdnacleavageandantimicrobialstudies AT sakthivela templatesynthesisofnovel14memberedtetraazamacrocyclictransitionmetalcomplexesdnacleavageandantimicrobialstudies
_version_	1718445389598687232

TEMPLATE SYNTHESIS OF NOVEL 14-MEMBERED TETRAAZAMACROCYCLIC TRANSITION METAL COMPLEXES: DNA CLEAVAGE AND ANTIMICROBIAL STUDIES

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