ELECTROCHEMICAL AND ELECTROPHORETIC STUDY OF SODIUM METAMIZOLE

Electrochemical and electrophoretic behavior of sodium metamizole under conditions of variable pH has been studied. Voltammetric results indicate that sodium metamizole behaves as a quasi-reversible system over the potential window considered. These studies were complemented with capillary zone elec...

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Autores principales:	BASÁEZ,LUISA, PERIC,IVÁN M, JARA,PAOLA A, SOTO,CESAR A, CONTRERAS,DAVID R, AGUIRRE,CAROLINA, VANÝSEK,PETR
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2008
Materias:	sodium metamizole NSAID drugs voltammetry electrochemical determination capillary zone electrophoresis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000300004
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spelling	oai:scielo:S0717-970720080003000042008-10-23ELECTROCHEMICAL AND ELECTROPHORETIC STUDY OF SODIUM METAMIZOLEBASÁEZ,LUISAPERIC,IVÁN MJARA,PAOLA ASOTO,CESAR ACONTRERAS,DAVID RAGUIRRE,CAROLINAVANÝSEK,PETR sodium metamizole NSAID drugs voltammetry electrochemical determination capillary zone electrophoresis Electrochemical and electrophoretic behavior of sodium metamizole under conditions of variable pH has been studied. Voltammetric results indicate that sodium metamizole behaves as a quasi-reversible system over the potential window considered. These studies were complemented with capillary zone electrophoresis analysis in order to know the starting composition of solutions of sodium metamizole at different pH valúes and buffer composition. Among degradation products , the extent of the active metabolite 4-methylaminoantipyrine was found to be media dependent as well as was the appearance of different degradation products . Consequently, the extent of the oxidation process in voltammetric studies is dependent on the composition of the starting solutions. Information obtained by cyclic voltammetry and capillary zone electrophoresis has been concordant and conclusive in that both methods can be used in a qualitative study of sodium metamizole, under the experimental conditions assayedinfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.53 n.3 20082008-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000300004en10.4067/S0717-97072008000300004
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	sodium metamizole NSAID drugs voltammetry electrochemical determination capillary zone electrophoresis
spellingShingle	sodium metamizole NSAID drugs voltammetry electrochemical determination capillary zone electrophoresis BASÁEZ,LUISA PERIC,IVÁN M JARA,PAOLA A SOTO,CESAR A CONTRERAS,DAVID R AGUIRRE,CAROLINA VANÝSEK,PETR ELECTROCHEMICAL AND ELECTROPHORETIC STUDY OF SODIUM METAMIZOLE
description	Electrochemical and electrophoretic behavior of sodium metamizole under conditions of variable pH has been studied. Voltammetric results indicate that sodium metamizole behaves as a quasi-reversible system over the potential window considered. These studies were complemented with capillary zone electrophoresis analysis in order to know the starting composition of solutions of sodium metamizole at different pH valúes and buffer composition. Among degradation products , the extent of the active metabolite 4-methylaminoantipyrine was found to be media dependent as well as was the appearance of different degradation products . Consequently, the extent of the oxidation process in voltammetric studies is dependent on the composition of the starting solutions. Information obtained by cyclic voltammetry and capillary zone electrophoresis has been concordant and conclusive in that both methods can be used in a qualitative study of sodium metamizole, under the experimental conditions assayed
author	BASÁEZ,LUISA PERIC,IVÁN M JARA,PAOLA A SOTO,CESAR A CONTRERAS,DAVID R AGUIRRE,CAROLINA VANÝSEK,PETR
author_facet	BASÁEZ,LUISA PERIC,IVÁN M JARA,PAOLA A SOTO,CESAR A CONTRERAS,DAVID R AGUIRRE,CAROLINA VANÝSEK,PETR
author_sort	BASÁEZ,LUISA
title	ELECTROCHEMICAL AND ELECTROPHORETIC STUDY OF SODIUM METAMIZOLE
title_short	ELECTROCHEMICAL AND ELECTROPHORETIC STUDY OF SODIUM METAMIZOLE
title_full	ELECTROCHEMICAL AND ELECTROPHORETIC STUDY OF SODIUM METAMIZOLE
title_fullStr	ELECTROCHEMICAL AND ELECTROPHORETIC STUDY OF SODIUM METAMIZOLE
title_full_unstemmed	ELECTROCHEMICAL AND ELECTROPHORETIC STUDY OF SODIUM METAMIZOLE
title_sort	electrochemical and electrophoretic study of sodium metamizole
publisher	Sociedad Chilena de Química
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000300004
work_keys_str_mv	AT basaezluisa electrochemicalandelectrophoreticstudyofsodiummetamizole AT pericivanm electrochemicalandelectrophoreticstudyofsodiummetamizole AT jarapaolaa electrochemicalandelectrophoreticstudyofsodiummetamizole AT sotocesara electrochemicalandelectrophoreticstudyofsodiummetamizole AT contrerasdavidr electrochemicalandelectrophoreticstudyofsodiummetamizole AT aguirrecarolina electrochemicalandelectrophoreticstudyofsodiummetamizole AT vanysekpetr electrochemicalandelectrophoreticstudyofsodiummetamizole
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ELECTROCHEMICAL AND ELECTROPHORETIC STUDY OF SODIUM METAMIZOLE

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