DESIGNING, SYNTHESIS, SPECTRAL CHARACTERIZATION OF ANTIMICROBIAL AND DNA ACTIVE TRIDENTATE SCHIFF BASE LIGANDS AND THEIR COMPLEXES

New neutral Schiff base tridentate ligand transition metal complexes of the composition, ML2 where M= Cu(II), Ni(II), Co(II) and Zn(II); L= ligands derived from semicarbazide hydrochloride and 2,4pentanedione/methyl acetoacetate/acetoacetanilide, were synthesized and characterized by elemental analy...

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Autores principales:	RAMAN,N, JOHNSON RAJA,S, JOSEPH,J, SAKTHIVEL,A, DHAVEETHU RAJA,J
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2008
Materias:	Schiff base Metal Complexes DNA Antimicrobial studies
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000300010
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spelling	oai:scielo:S0717-970720080003000102008-10-23DESIGNING, SYNTHESIS, SPECTRAL CHARACTERIZATION OF ANTIMICROBIAL AND DNA ACTIVE TRIDENTATE SCHIFF BASE LIGANDS AND THEIR COMPLEXESRAMAN,NJOHNSON RAJA,SJOSEPH,JSAKTHIVEL,ADHAVEETHU RAJA,J Schiff base Metal Complexes DNA Antimicrobial studies New neutral Schiff base tridentate ligand transition metal complexes of the composition, ML2 where M= Cu(II), Ni(II), Co(II) and Zn(II); L= ligands derived from semicarbazide hydrochloride and 2,4pentanedione/methyl acetoacetate/acetoacetanilide, were synthesized and characterized by elemental analyses, magnetic susceptibility, IR, UV-Vis., ¹H-NMR, 13C-NMR, CV, ESR, and FAB-mass spectral techniques. Electronic absorption spectra of the complexes indícate an octahedral geometry around the metal ion. The magnetic susceptibility measurements and low conductance data provide evidence for the monomeric and neutral natures of the complexes respective ly. The electrochemical behaviour, the anodic and cathodic potential and the number of electrón transfer were calculated using cyclic voltammogram. The X-band ESR spectrum of copper complex in DMSO at 300 K and 77 K was recorded and its salient features are reported. The antimicrobial activities of the ligands and their complexes have been studied by screening the compounds against the bacteria E. coli, P.aeruginosa, P.mirabilis, S. typhi, and B.subtilis and also the fungi C.albicans and R. stolonifer and results have been compared with the standard drug, amphicillin. The data indícate that most of the metal complexes have higher antimicrobial activity than the free ligands and the standard. The DNA cleavage experiments, performed using gel electrophoresis with the corresponding metal complexes in the presence of H(2)0(2) showed all the complexes afford a pronounced discernible DNA cleavage evidenced by the disappearance of Form I (supercoiled) of plasmid and the production of Form III (linear)info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.53 n.3 20082008-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000300010en10.4067/S0717-97072008000300010
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Schiff base Metal Complexes DNA Antimicrobial studies
spellingShingle	Schiff base Metal Complexes DNA Antimicrobial studies RAMAN,N JOHNSON RAJA,S JOSEPH,J SAKTHIVEL,A DHAVEETHU RAJA,J DESIGNING, SYNTHESIS, SPECTRAL CHARACTERIZATION OF ANTIMICROBIAL AND DNA ACTIVE TRIDENTATE SCHIFF BASE LIGANDS AND THEIR COMPLEXES
description	New neutral Schiff base tridentate ligand transition metal complexes of the composition, ML2 where M= Cu(II), Ni(II), Co(II) and Zn(II); L= ligands derived from semicarbazide hydrochloride and 2,4pentanedione/methyl acetoacetate/acetoacetanilide, were synthesized and characterized by elemental analyses, magnetic susceptibility, IR, UV-Vis., ¹H-NMR, 13C-NMR, CV, ESR, and FAB-mass spectral techniques. Electronic absorption spectra of the complexes indícate an octahedral geometry around the metal ion. The magnetic susceptibility measurements and low conductance data provide evidence for the monomeric and neutral natures of the complexes respective ly. The electrochemical behaviour, the anodic and cathodic potential and the number of electrón transfer were calculated using cyclic voltammogram. The X-band ESR spectrum of copper complex in DMSO at 300 K and 77 K was recorded and its salient features are reported. The antimicrobial activities of the ligands and their complexes have been studied by screening the compounds against the bacteria E. coli, P.aeruginosa, P.mirabilis, S. typhi, and B.subtilis and also the fungi C.albicans and R. stolonifer and results have been compared with the standard drug, amphicillin. The data indícate that most of the metal complexes have higher antimicrobial activity than the free ligands and the standard. The DNA cleavage experiments, performed using gel electrophoresis with the corresponding metal complexes in the presence of H(2)0(2) showed all the complexes afford a pronounced discernible DNA cleavage evidenced by the disappearance of Form I (supercoiled) of plasmid and the production of Form III (linear)
author	RAMAN,N JOHNSON RAJA,S JOSEPH,J SAKTHIVEL,A DHAVEETHU RAJA,J
author_facet	RAMAN,N JOHNSON RAJA,S JOSEPH,J SAKTHIVEL,A DHAVEETHU RAJA,J
author_sort	RAMAN,N
title	DESIGNING, SYNTHESIS, SPECTRAL CHARACTERIZATION OF ANTIMICROBIAL AND DNA ACTIVE TRIDENTATE SCHIFF BASE LIGANDS AND THEIR COMPLEXES
title_short	DESIGNING, SYNTHESIS, SPECTRAL CHARACTERIZATION OF ANTIMICROBIAL AND DNA ACTIVE TRIDENTATE SCHIFF BASE LIGANDS AND THEIR COMPLEXES
title_full	DESIGNING, SYNTHESIS, SPECTRAL CHARACTERIZATION OF ANTIMICROBIAL AND DNA ACTIVE TRIDENTATE SCHIFF BASE LIGANDS AND THEIR COMPLEXES
title_fullStr	DESIGNING, SYNTHESIS, SPECTRAL CHARACTERIZATION OF ANTIMICROBIAL AND DNA ACTIVE TRIDENTATE SCHIFF BASE LIGANDS AND THEIR COMPLEXES
title_full_unstemmed	DESIGNING, SYNTHESIS, SPECTRAL CHARACTERIZATION OF ANTIMICROBIAL AND DNA ACTIVE TRIDENTATE SCHIFF BASE LIGANDS AND THEIR COMPLEXES
title_sort	designing, synthesis, spectral characterization of antimicrobial and dna active tridentate schiff base ligands and their complexes
publisher	Sociedad Chilena de Química
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000300010
work_keys_str_mv	AT ramann designingsynthesisspectralcharacterizationofantimicrobialanddnaactivetridentateschiffbaseligandsandtheircomplexes AT johnsonrajas designingsynthesisspectralcharacterizationofantimicrobialanddnaactivetridentateschiffbaseligandsandtheircomplexes AT josephj designingsynthesisspectralcharacterizationofantimicrobialanddnaactivetridentateschiffbaseligandsandtheircomplexes AT sakthivela designingsynthesisspectralcharacterizationofantimicrobialanddnaactivetridentateschiffbaseligandsandtheircomplexes AT dhaveethurajaj designingsynthesisspectralcharacterizationofantimicrobialanddnaactivetridentateschiffbaseligandsandtheircomplexes
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DESIGNING, SYNTHESIS, SPECTRAL CHARACTERIZATION OF ANTIMICROBIAL AND DNA ACTIVE TRIDENTATE SCHIFF BASE LIGANDS AND THEIR COMPLEXES

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