FLOW INJECTION SPECTROPHOTOMETRIC DETERMINATION OF FLUOXETINE IN BULK AND IN PHARMACEUTICAL PREPARATIONS

Sensitive and reproducible flow injection spectrophotometric method for determination of fluoxetine in pharmaceutical preparation has been developed. The method is based on base hydrolysis of the drug. The hydrolyzed product methylamine is reacted with sodium nitroprusside. The absorbance of the res...

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Autores principales:	SHAH,JASMIN, RASUL JAN,M, REHMAN,FOZIA
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2008
Materias:	Fluoxetine hydrolysis flow injection spectrophotometric
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000300011
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spelling	oai:scielo:S0717-970720080003000112008-10-23FLOW INJECTION SPECTROPHOTOMETRIC DETERMINATION OF FLUOXETINE IN BULK AND IN PHARMACEUTICAL PREPARATIONSSHAH,JASMINRASUL JAN,MREHMAN,FOZIA Fluoxetine hydrolysis flow injection spectrophotometric Sensitive and reproducible flow injection spectrophotometric method for determination of fluoxetine in pharmaceutical preparation has been developed. The method is based on base hydrolysis of the drug. The hydrolyzed product methylamine is reacted with sodium nitroprusside. The absorbance of the resulting colored product was measured spectrophtometrically at 510 nm using flow injection method. The method showed a linear range 0.5-25 mg/L with a molar absorptivity of 2.19 x 10(4). The % recovery for determination of flouxitine in formulations was found to be 99.7±0.18-99.4±0.22. The limit of detection and quantification was calculated and found 0.15±0.01 mg/L and 0.29±0.03 mg/L respectively. The proposed method was successfully applied to the pharmaceutical preparations-capsules and tabletsinfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.53 n.3 20082008-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000300011en10.4067/S0717-97072008000300011
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Fluoxetine hydrolysis flow injection spectrophotometric
spellingShingle	Fluoxetine hydrolysis flow injection spectrophotometric SHAH,JASMIN RASUL JAN,M REHMAN,FOZIA FLOW INJECTION SPECTROPHOTOMETRIC DETERMINATION OF FLUOXETINE IN BULK AND IN PHARMACEUTICAL PREPARATIONS
description	Sensitive and reproducible flow injection spectrophotometric method for determination of fluoxetine in pharmaceutical preparation has been developed. The method is based on base hydrolysis of the drug. The hydrolyzed product methylamine is reacted with sodium nitroprusside. The absorbance of the resulting colored product was measured spectrophtometrically at 510 nm using flow injection method. The method showed a linear range 0.5-25 mg/L with a molar absorptivity of 2.19 x 10(4). The % recovery for determination of flouxitine in formulations was found to be 99.7±0.18-99.4±0.22. The limit of detection and quantification was calculated and found 0.15±0.01 mg/L and 0.29±0.03 mg/L respectively. The proposed method was successfully applied to the pharmaceutical preparations-capsules and tablets
author	SHAH,JASMIN RASUL JAN,M REHMAN,FOZIA
author_facet	SHAH,JASMIN RASUL JAN,M REHMAN,FOZIA
author_sort	SHAH,JASMIN
title	FLOW INJECTION SPECTROPHOTOMETRIC DETERMINATION OF FLUOXETINE IN BULK AND IN PHARMACEUTICAL PREPARATIONS
title_short	FLOW INJECTION SPECTROPHOTOMETRIC DETERMINATION OF FLUOXETINE IN BULK AND IN PHARMACEUTICAL PREPARATIONS
title_full	FLOW INJECTION SPECTROPHOTOMETRIC DETERMINATION OF FLUOXETINE IN BULK AND IN PHARMACEUTICAL PREPARATIONS
title_fullStr	FLOW INJECTION SPECTROPHOTOMETRIC DETERMINATION OF FLUOXETINE IN BULK AND IN PHARMACEUTICAL PREPARATIONS
title_full_unstemmed	FLOW INJECTION SPECTROPHOTOMETRIC DETERMINATION OF FLUOXETINE IN BULK AND IN PHARMACEUTICAL PREPARATIONS
title_sort	flow injection spectrophotometric determination of fluoxetine in bulk and in pharmaceutical preparations
publisher	Sociedad Chilena de Química
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000300011
work_keys_str_mv	AT shahjasmin flowinjectionspectrophotometricdeterminationoffluoxetineinbulkandinpharmaceuticalpreparations AT rasuljanm flowinjectionspectrophotometricdeterminationoffluoxetineinbulkandinpharmaceuticalpreparations AT rehmanfozia flowinjectionspectrophotometricdeterminationoffluoxetineinbulkandinpharmaceuticalpreparations
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FLOW INJECTION SPECTROPHOTOMETRIC DETERMINATION OF FLUOXETINE IN BULK AND IN PHARMACEUTICAL PREPARATIONS

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