CHEMICAL CONSTITUENTS FROM THE STEM BARK OF ZANTHOXYLUM SCANDENS

One new dioxoaporphine alkaloid, zanthodione (1), together with nineteen known compounds have been isolated from the stem bark of Zanthoxylum scandens. The structures of these compounds were determined by means of spectral analyses. Except for zanthodione (1), methyl vanillate, vanillic acid, and 2-...

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Autores principales:	CHENG,MING-JEN, LIN,CHUAN-FANG, CHANG,HSUN- SHUO, CHEN,IH-SHENG
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2008
Materias:	Zanthoxylum scandens Rutaceae stem bark dioxoaporphine anti-HIV activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000300019
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spelling	oai:scielo:S0717-970720080003000192008-10-23CHEMICAL CONSTITUENTS FROM THE STEM BARK OF ZANTHOXYLUM SCANDENSCHENG,MING-JENLIN,CHUAN-FANGCHANG,HSUN- SHUOCHEN,IH-SHENG Zanthoxylum scandens Rutaceae stem bark dioxoaporphine anti-HIV activity One new dioxoaporphine alkaloid, zanthodione (1), together with nineteen known compounds have been isolated from the stem bark of Zanthoxylum scandens. The structures of these compounds were determined by means of spectral analyses. Except for zanthodione (1), methyl vanillate, vanillic acid, and 2-(4'-hydroxyphenyl)ethyl hexacosanoate, all of the other 16 compounds, as same constituents found in Z. ailanthoides, which were evaluated for inhibition of HIV replication in H9 lymphocyte cells in our previous report in Bioorg. Med. Chem.. The reported decarine, γ-fagarine, and (+)-platydesmine were the most potent anti-HIV constituents, with EC50 values ranging from 0.1 to 1.34 µg/mL and TI (Therapeutic index) values from 74 to 231, also isolated from the stem bark of this plantinfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.53 n.3 20082008-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000300019en10.4067/S0717-97072008000300019
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Zanthoxylum scandens Rutaceae stem bark dioxoaporphine anti-HIV activity
spellingShingle	Zanthoxylum scandens Rutaceae stem bark dioxoaporphine anti-HIV activity CHENG,MING-JEN LIN,CHUAN-FANG CHANG,HSUN- SHUO CHEN,IH-SHENG CHEMICAL CONSTITUENTS FROM THE STEM BARK OF ZANTHOXYLUM SCANDENS
description	One new dioxoaporphine alkaloid, zanthodione (1), together with nineteen known compounds have been isolated from the stem bark of Zanthoxylum scandens. The structures of these compounds were determined by means of spectral analyses. Except for zanthodione (1), methyl vanillate, vanillic acid, and 2-(4'-hydroxyphenyl)ethyl hexacosanoate, all of the other 16 compounds, as same constituents found in Z. ailanthoides, which were evaluated for inhibition of HIV replication in H9 lymphocyte cells in our previous report in Bioorg. Med. Chem.. The reported decarine, γ-fagarine, and (+)-platydesmine were the most potent anti-HIV constituents, with EC50 values ranging from 0.1 to 1.34 µg/mL and TI (Therapeutic index) values from 74 to 231, also isolated from the stem bark of this plant
author	CHENG,MING-JEN LIN,CHUAN-FANG CHANG,HSUN- SHUO CHEN,IH-SHENG
author_facet	CHENG,MING-JEN LIN,CHUAN-FANG CHANG,HSUN- SHUO CHEN,IH-SHENG
author_sort	CHENG,MING-JEN
title	CHEMICAL CONSTITUENTS FROM THE STEM BARK OF ZANTHOXYLUM SCANDENS
title_short	CHEMICAL CONSTITUENTS FROM THE STEM BARK OF ZANTHOXYLUM SCANDENS
title_full	CHEMICAL CONSTITUENTS FROM THE STEM BARK OF ZANTHOXYLUM SCANDENS
title_fullStr	CHEMICAL CONSTITUENTS FROM THE STEM BARK OF ZANTHOXYLUM SCANDENS
title_full_unstemmed	CHEMICAL CONSTITUENTS FROM THE STEM BARK OF ZANTHOXYLUM SCANDENS
title_sort	chemical constituents from the stem bark of zanthoxylum scandens
publisher	Sociedad Chilena de Química
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000300019
work_keys_str_mv	AT chengmingjen chemicalconstituentsfromthestembarkofzanthoxylumscandens AT linchuanfang chemicalconstituentsfromthestembarkofzanthoxylumscandens AT changhsunshuo chemicalconstituentsfromthestembarkofzanthoxylumscandens AT chenihsheng chemicalconstituentsfromthestembarkofzanthoxylumscandens
_version_	1718445392370073600

CHEMICAL CONSTITUENTS FROM THE STEM BARK OF ZANTHOXYLUM SCANDENS

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