ENCAPSULATION OF LEU-ENKEPHALIN IN CORE-SHELL ISOBUTYLCYANOACRYLATE - THIOLATED CHITOSAN NANOPARTICLES FOR ORAL ADMINISTRATION
The present study shows the evaluation of Leu-Enkephalin (Leu-Enk) encapsulation on core-shell isobutylcyanoacrylate/thiolated chitosan (IBCA/ChitoTBA) nanoparticles as a tool of combined system of polymers and colloidal particles for oral administration of poor absorption drugs. Leu-Enk encapsulati...
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| Autores principales: | , , , |
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| Lenguaje: | English |
| Publicado: |
Sociedad Chilena de Química
2008
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| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000400008 |
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| Sumario: | The present study shows the evaluation of Leu-Enkephalin (Leu-Enk) encapsulation on core-shell isobutylcyanoacrylate/thiolated chitosan (IBCA/ChitoTBA) nanoparticles as a tool of combined system of polymers and colloidal particles for oral administration of poor absorption drugs. Leu-Enk encapsulation using anionic emulsión polymerization technique was carried out previous depolymerization of MW 400,000 gmol"¹ commercial chitosan, followed by thiolation of this depolymerized chitosan with Traut's reagent (2-iminothiolane), and final characterization. Later, direct quantification of the encapsulated Leu-Enk into the nanoparticles was carried out evaluating two methodologies for nanoparticles rupture solubilization with: NaOH 1 N and DMSO. Physico-chemical characterization of the obtained nanoparticles showed diameters in the nano-range between 28 and 46 nm, and yields of encapsulation of Leu-Enk between 25 and 46%, and recovery yields over 96% for co-polymer nanoparticles solubilization method with DMSO. |
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