ENCAPSULATION OF LEU-ENKEPHALIN IN CORE-SHELL ISOBUTYLCYANOACRYLATE - THIOLATED CHITOSAN NANOPARTICLES FOR ORAL ADMINISTRATION

The present study shows the evaluation of Leu-Enkephalin (Leu-Enk) encapsulation on core-shell isobutylcyanoacrylate/thiolated chitosan (IBCA/ChitoTBA) nanoparticles as a tool of combined system of polymers and colloidal particles for oral administration of poor absorption drugs. Leu-Enk encapsulati...

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Autores principales:	CAMPOS REQUENA,VÍCTOR H, BOUCHEMAL,KAWTHAR, VAUTHIER,CHRISTINE, PONCHEL,GILLES
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2008
Materias:	nanoparticles leu-enkephalin isobutylcyanoacrylate thiolated chitosan thiomers anionic emulsion polymerization
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000400008
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spelling	oai:scielo:S0717-970720080004000082009-05-22ENCAPSULATION OF LEU-ENKEPHALIN IN CORE-SHELL ISOBUTYLCYANOACRYLATE - THIOLATED CHITOSAN NANOPARTICLES FOR ORAL ADMINISTRATIONCAMPOS REQUENA,VÍCTOR HBOUCHEMAL,KAWTHARVAUTHIER,CHRISTINEPONCHEL,GILLES nanoparticles leu-enkephalin isobutylcyanoacrylate thiolated chitosan thiomers anionic emulsion polymerization The present study shows the evaluation of Leu-Enkephalin (Leu-Enk) encapsulation on core-shell isobutylcyanoacrylate/thiolated chitosan (IBCA/ChitoTBA) nanoparticles as a tool of combined system of polymers and colloidal particles for oral administration of poor absorption drugs. Leu-Enk encapsulation using anionic emulsión polymerization technique was carried out previous depolymerization of MW 400,000 gmol"¹ commercial chitosan, followed by thiolation of this depolymerized chitosan with Traut's reagent (2-iminothiolane), and final characterization. Later, direct quantification of the encapsulated Leu-Enk into the nanoparticles was carried out evaluating two methodologies for nanoparticles rupture solubilization with: NaOH 1 N and DMSO. Physico-chemical characterization of the obtained nanoparticles showed diameters in the nano-range between 28 and 46 nm, and yields of encapsulation of Leu-Enk between 25 and 46%, and recovery yields over 96% for co-polymer nanoparticles solubilization method with DMSO.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.53 n.4 20082008-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000400008en10.4067/S0717-97072008000400008
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	nanoparticles leu-enkephalin isobutylcyanoacrylate thiolated chitosan thiomers anionic emulsion polymerization
spellingShingle	nanoparticles leu-enkephalin isobutylcyanoacrylate thiolated chitosan thiomers anionic emulsion polymerization CAMPOS REQUENA,VÍCTOR H BOUCHEMAL,KAWTHAR VAUTHIER,CHRISTINE PONCHEL,GILLES ENCAPSULATION OF LEU-ENKEPHALIN IN CORE-SHELL ISOBUTYLCYANOACRYLATE - THIOLATED CHITOSAN NANOPARTICLES FOR ORAL ADMINISTRATION
description	The present study shows the evaluation of Leu-Enkephalin (Leu-Enk) encapsulation on core-shell isobutylcyanoacrylate/thiolated chitosan (IBCA/ChitoTBA) nanoparticles as a tool of combined system of polymers and colloidal particles for oral administration of poor absorption drugs. Leu-Enk encapsulation using anionic emulsión polymerization technique was carried out previous depolymerization of MW 400,000 gmol"¹ commercial chitosan, followed by thiolation of this depolymerized chitosan with Traut's reagent (2-iminothiolane), and final characterization. Later, direct quantification of the encapsulated Leu-Enk into the nanoparticles was carried out evaluating two methodologies for nanoparticles rupture solubilization with: NaOH 1 N and DMSO. Physico-chemical characterization of the obtained nanoparticles showed diameters in the nano-range between 28 and 46 nm, and yields of encapsulation of Leu-Enk between 25 and 46%, and recovery yields over 96% for co-polymer nanoparticles solubilization method with DMSO.
author	CAMPOS REQUENA,VÍCTOR H BOUCHEMAL,KAWTHAR VAUTHIER,CHRISTINE PONCHEL,GILLES
author_facet	CAMPOS REQUENA,VÍCTOR H BOUCHEMAL,KAWTHAR VAUTHIER,CHRISTINE PONCHEL,GILLES
author_sort	CAMPOS REQUENA,VÍCTOR H
title	ENCAPSULATION OF LEU-ENKEPHALIN IN CORE-SHELL ISOBUTYLCYANOACRYLATE - THIOLATED CHITOSAN NANOPARTICLES FOR ORAL ADMINISTRATION
title_short	ENCAPSULATION OF LEU-ENKEPHALIN IN CORE-SHELL ISOBUTYLCYANOACRYLATE - THIOLATED CHITOSAN NANOPARTICLES FOR ORAL ADMINISTRATION
title_full	ENCAPSULATION OF LEU-ENKEPHALIN IN CORE-SHELL ISOBUTYLCYANOACRYLATE - THIOLATED CHITOSAN NANOPARTICLES FOR ORAL ADMINISTRATION
title_fullStr	ENCAPSULATION OF LEU-ENKEPHALIN IN CORE-SHELL ISOBUTYLCYANOACRYLATE - THIOLATED CHITOSAN NANOPARTICLES FOR ORAL ADMINISTRATION
title_full_unstemmed	ENCAPSULATION OF LEU-ENKEPHALIN IN CORE-SHELL ISOBUTYLCYANOACRYLATE - THIOLATED CHITOSAN NANOPARTICLES FOR ORAL ADMINISTRATION
title_sort	encapsulation of leu-enkephalin in core-shell isobutylcyanoacrylate - thiolated chitosan nanoparticles for oral administration
publisher	Sociedad Chilena de Química
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000400008
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_version_	1718445394146361344

ENCAPSULATION OF LEU-ENKEPHALIN IN CORE-SHELL ISOBUTYLCYANOACRYLATE - THIOLATED CHITOSAN NANOPARTICLES FOR ORAL ADMINISTRATION

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