RUTHENIUM (III) - CATALYZED OXIDATWE CLEAVAGE OF PHENYLPROPANOLAMINE HYDROCHLORIDE WITH SODIUM N-CHOROBEZENESULFONAMIDE IN ACID MEDIUM: A KINETIC AND MECHANISTIC STUDY

Phenylpropanolamine hydrochloride (2-amino-l-phenylpropanol hydrochloride) is a sympathomimetric drug used for nasal congestión associated with the common cold, allergies, high fever, or other respiratory illness. The kinetics of oxidation of phenylpropanolamine hydrochloride (PPA) with sodium N-chl...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	MOHANA,KIKKERI N, PRASAD,NINGEGOWDA
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2008
Materias:	Phenylpropanolamine hydrochloride chloramine-B oxidation Kinetics Ru(III)-catalysis acid medium
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000400013
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-97072008000400013
record_format	dspace
spelling	oai:scielo:S0717-970720080004000132009-05-22RUTHENIUM (III) - CATALYZED OXIDATWE CLEAVAGE OF PHENYLPROPANOLAMINE HYDROCHLORIDE WITH SODIUM N-CHOROBEZENESULFONAMIDE IN ACID MEDIUM: A KINETIC AND MECHANISTIC STUDYMOHANA,KIKKERI NPRASAD,NINGEGOWDA Phenylpropanolamine hydrochloride chloramine-B oxidation Kinetics Ru(III)-catalysis acid medium Phenylpropanolamine hydrochloride (2-amino-l-phenylpropanol hydrochloride) is a sympathomimetric drug used for nasal congestión associated with the common cold, allergies, high fever, or other respiratory illness. The kinetics of oxidation of phenylpropanolamine hydrochloride (PPA) with sodium N-chlorobenzenesulfonamide or chloramine-B (CAB) catalyzed by Ru (III) in hydrochloric acid médium has been studied at 308 K. The oxidation reaction follows the rate law, - d [CAB]/dt = k [CAB] [H+]x [PPA]y [Ru(III)]z, where x, y and z are less than unity. Addition of chloride ions, perchlorate ions and the reduction product of CAB, benzenesulfonamide (BSA), have no significant effect on the rate. Decrease of dielectric permittivity of the médium by increasing the CH3CN content increased the rate. The reaction was studied at different temperatures and the activation parameters have been computed from the Arrhenius plot. The stoichiometery of the reaction was foundto be 1:1 and the main oxidation producís of PPA were found to be benzaldehyde and acetaldehyde. The rate constant decreases in D(2)0 médium and the normal isotope effect, k' (H(2)0) / k' (D(2)0) is 2.39. Proton inventory studies have been made in H(2)0-D(2)0 mixtures. Formation and decomposition constant of CAB-PPA complexes in the reaction scheme have been evaluated. The conjúgate acid C6H5S0(2)NHC1 has been assumed to be the reactive species. The observed results have been explained by plausible mechanisms and relative rate law has been deduced.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.53 n.4 20082008-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000400013en10.4067/S0717-97072008000400013
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Phenylpropanolamine hydrochloride chloramine-B oxidation Kinetics Ru(III)-catalysis acid medium
spellingShingle	Phenylpropanolamine hydrochloride chloramine-B oxidation Kinetics Ru(III)-catalysis acid medium MOHANA,KIKKERI N PRASAD,NINGEGOWDA RUTHENIUM (III) - CATALYZED OXIDATWE CLEAVAGE OF PHENYLPROPANOLAMINE HYDROCHLORIDE WITH SODIUM N-CHOROBEZENESULFONAMIDE IN ACID MEDIUM: A KINETIC AND MECHANISTIC STUDY
description	Phenylpropanolamine hydrochloride (2-amino-l-phenylpropanol hydrochloride) is a sympathomimetric drug used for nasal congestión associated with the common cold, allergies, high fever, or other respiratory illness. The kinetics of oxidation of phenylpropanolamine hydrochloride (PPA) with sodium N-chlorobenzenesulfonamide or chloramine-B (CAB) catalyzed by Ru (III) in hydrochloric acid médium has been studied at 308 K. The oxidation reaction follows the rate law, - d [CAB]/dt = k [CAB] [H+]x [PPA]y [Ru(III)]z, where x, y and z are less than unity. Addition of chloride ions, perchlorate ions and the reduction product of CAB, benzenesulfonamide (BSA), have no significant effect on the rate. Decrease of dielectric permittivity of the médium by increasing the CH3CN content increased the rate. The reaction was studied at different temperatures and the activation parameters have been computed from the Arrhenius plot. The stoichiometery of the reaction was foundto be 1:1 and the main oxidation producís of PPA were found to be benzaldehyde and acetaldehyde. The rate constant decreases in D(2)0 médium and the normal isotope effect, k' (H(2)0) / k' (D(2)0) is 2.39. Proton inventory studies have been made in H(2)0-D(2)0 mixtures. Formation and decomposition constant of CAB-PPA complexes in the reaction scheme have been evaluated. The conjúgate acid C6H5S0(2)NHC1 has been assumed to be the reactive species. The observed results have been explained by plausible mechanisms and relative rate law has been deduced.
author	MOHANA,KIKKERI N PRASAD,NINGEGOWDA
author_facet	MOHANA,KIKKERI N PRASAD,NINGEGOWDA
author_sort	MOHANA,KIKKERI N
title	RUTHENIUM (III) - CATALYZED OXIDATWE CLEAVAGE OF PHENYLPROPANOLAMINE HYDROCHLORIDE WITH SODIUM N-CHOROBEZENESULFONAMIDE IN ACID MEDIUM: A KINETIC AND MECHANISTIC STUDY
title_short	RUTHENIUM (III) - CATALYZED OXIDATWE CLEAVAGE OF PHENYLPROPANOLAMINE HYDROCHLORIDE WITH SODIUM N-CHOROBEZENESULFONAMIDE IN ACID MEDIUM: A KINETIC AND MECHANISTIC STUDY
title_full	RUTHENIUM (III) - CATALYZED OXIDATWE CLEAVAGE OF PHENYLPROPANOLAMINE HYDROCHLORIDE WITH SODIUM N-CHOROBEZENESULFONAMIDE IN ACID MEDIUM: A KINETIC AND MECHANISTIC STUDY
title_fullStr	RUTHENIUM (III) - CATALYZED OXIDATWE CLEAVAGE OF PHENYLPROPANOLAMINE HYDROCHLORIDE WITH SODIUM N-CHOROBEZENESULFONAMIDE IN ACID MEDIUM: A KINETIC AND MECHANISTIC STUDY
title_full_unstemmed	RUTHENIUM (III) - CATALYZED OXIDATWE CLEAVAGE OF PHENYLPROPANOLAMINE HYDROCHLORIDE WITH SODIUM N-CHOROBEZENESULFONAMIDE IN ACID MEDIUM: A KINETIC AND MECHANISTIC STUDY
title_sort	ruthenium (iii) - catalyzed oxidatwe cleavage of phenylpropanolamine hydrochloride with sodium n-chorobezenesulfonamide in acid medium: a kinetic and mechanistic study
publisher	Sociedad Chilena de Química
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000400013
work_keys_str_mv	AT mohanakikkerin rutheniumiiicatalyzedoxidatwecleavageofphenylpropanolaminehydrochloridewithsodiumnchorobezenesulfonamideinacidmediumakineticandmechanisticstudy AT prasadningegowda rutheniumiiicatalyzedoxidatwecleavageofphenylpropanolaminehydrochloridewithsodiumnchorobezenesulfonamideinacidmediumakineticandmechanisticstudy
_version_	1718445395012485120

RUTHENIUM (III) - CATALYZED OXIDATWE CLEAVAGE OF PHENYLPROPANOLAMINE HYDROCHLORIDE WITH SODIUM N-CHOROBEZENESULFONAMIDE IN ACID MEDIUM: A KINETIC AND MECHANISTIC STUDY

Ejemplares similares