SOLUBILIZATION OF DPPC SMALL UNILAMELLAR LIPOSOMES BY SUCROSE ESTERS: A FLUORESCENCE STUDY

The effect of the microenvironment on the Laurdan fluorescence was employed to study the solubilization mechanism of Dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) small unilamellar vesicles with several sucrose monoesters. The saturation and the solubilization concentrations (C and C ), the ester-D...

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Autores principales:	BERRIOS,EDUARDO, ZANOCCO,ANTONIO L, LEMP,ELSE, GÜNTHER,GERMÁN
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2008
Materias:	Liposomes solubilization sucrose esters Laurdan lauryl sucrose palmityl sucrose myristyl sucrose stearyl sucrose SUVs
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000400021
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spelling	oai:scielo:S0717-970720080004000212009-05-22SOLUBILIZATION OF DPPC SMALL UNILAMELLAR LIPOSOMES BY SUCROSE ESTERS: A FLUORESCENCE STUDYBERRIOS,EDUARDOZANOCCO,ANTONIO LLEMP,ELSEGÜNTHER,GERMÁN Liposomes solubilization sucrose esters Laurdan lauryl sucrose palmityl sucrose myristyl sucrose stearyl sucrose SUVs The effect of the microenvironment on the Laurdan fluorescence was employed to study the solubilization mechanism of Dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) small unilamellar vesicles with several sucrose monoesters. The saturation and the solubilization concentrations (C and C ), the ester-DPPC molar ratio (R ) and the bilayer/aqueous partition coefficients (K) were measured by monitoring changes in laurdan generalized polarization for four different alkyl esters of sucrose. All critical concentrations showed linear dependence with DPPC Hposomes concentration. The saturation and the solubilization capacity of this type of surfactant do not show a direct dependence with the length of its alkyl chain. For the studied series the lauryl sucrose derivative is the compound which presents the higher capacity to satúrate and solubilize the DPPC vesicles, while the capacity of the esters with shorter and longer alkyl chains worsen. When the results obtained for DPPC hposomes are compared with previously obtained data for DODAC a different structuration of sucrose moieties in the bilayer can be postulated.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.53 n.4 20082008-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000400021en10.4067/S0717-97072008000400021
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Liposomes solubilization sucrose esters Laurdan lauryl sucrose palmityl sucrose myristyl sucrose stearyl sucrose SUVs
spellingShingle	Liposomes solubilization sucrose esters Laurdan lauryl sucrose palmityl sucrose myristyl sucrose stearyl sucrose SUVs BERRIOS,EDUARDO ZANOCCO,ANTONIO L LEMP,ELSE GÜNTHER,GERMÁN SOLUBILIZATION OF DPPC SMALL UNILAMELLAR LIPOSOMES BY SUCROSE ESTERS: A FLUORESCENCE STUDY
description	The effect of the microenvironment on the Laurdan fluorescence was employed to study the solubilization mechanism of Dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) small unilamellar vesicles with several sucrose monoesters. The saturation and the solubilization concentrations (C and C ), the ester-DPPC molar ratio (R ) and the bilayer/aqueous partition coefficients (K) were measured by monitoring changes in laurdan generalized polarization for four different alkyl esters of sucrose. All critical concentrations showed linear dependence with DPPC Hposomes concentration. The saturation and the solubilization capacity of this type of surfactant do not show a direct dependence with the length of its alkyl chain. For the studied series the lauryl sucrose derivative is the compound which presents the higher capacity to satúrate and solubilize the DPPC vesicles, while the capacity of the esters with shorter and longer alkyl chains worsen. When the results obtained for DPPC hposomes are compared with previously obtained data for DODAC a different structuration of sucrose moieties in the bilayer can be postulated.
author	BERRIOS,EDUARDO ZANOCCO,ANTONIO L LEMP,ELSE GÜNTHER,GERMÁN
author_facet	BERRIOS,EDUARDO ZANOCCO,ANTONIO L LEMP,ELSE GÜNTHER,GERMÁN
author_sort	BERRIOS,EDUARDO
title	SOLUBILIZATION OF DPPC SMALL UNILAMELLAR LIPOSOMES BY SUCROSE ESTERS: A FLUORESCENCE STUDY
title_short	SOLUBILIZATION OF DPPC SMALL UNILAMELLAR LIPOSOMES BY SUCROSE ESTERS: A FLUORESCENCE STUDY
title_full	SOLUBILIZATION OF DPPC SMALL UNILAMELLAR LIPOSOMES BY SUCROSE ESTERS: A FLUORESCENCE STUDY
title_fullStr	SOLUBILIZATION OF DPPC SMALL UNILAMELLAR LIPOSOMES BY SUCROSE ESTERS: A FLUORESCENCE STUDY
title_full_unstemmed	SOLUBILIZATION OF DPPC SMALL UNILAMELLAR LIPOSOMES BY SUCROSE ESTERS: A FLUORESCENCE STUDY
title_sort	solubilization of dppc small unilamellar liposomes by sucrose esters: a fluorescence study
publisher	Sociedad Chilena de Química
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000400021
work_keys_str_mv	AT berrioseduardo solubilizationofdppcsmallunilamellarliposomesbysucroseestersafluorescencestudy AT zanoccoantoniol solubilizationofdppcsmallunilamellarliposomesbysucroseestersafluorescencestudy AT lempelse solubilizationofdppcsmallunilamellarliposomesbysucroseestersafluorescencestudy AT gunthergerman solubilizationofdppcsmallunilamellarliposomesbysucroseestersafluorescencestudy
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SOLUBILIZATION OF DPPC SMALL UNILAMELLAR LIPOSOMES BY SUCROSE ESTERS: A FLUORESCENCE STUDY

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