A VOLTAMMETRIC STUDY ON THE INTERACTION OF NOVOBIOCIN WITH CYSTEINE

The interaction of novobiocin (NOV), an aminocoumarin antibiotic, with cysteine was studied by square-wave voltammetry technique on the hanging mercury drop electrode in different pH values. After the addition of NOV into the cysteine solution, the peak current of mercurous cysteine thiolate decreas...

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Autores principales:	BÇER,ENDER, QETNKAYA,PAKZE
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2009
Materias:	Voltammetry Novobiocin Cysteine Interaction pH effect
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000100011
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spelling	oai:scielo:S0717-970720090001000112009-05-12A VOLTAMMETRIC STUDY ON THE INTERACTION OF NOVOBIOCIN WITH CYSTEINEBÇER,ENDERQETNKAYA,PAKZE Voltammetry Novobiocin Cysteine Interaction pH effect The interaction of novobiocin (NOV), an aminocoumarin antibiotic, with cysteine was studied by square-wave voltammetry technique on the hanging mercury drop electrode in different pH values. After the addition of NOV into the cysteine solution, the peak current of mercurous cysteine thiolate decreased and its voltammetric peak potential shifted to more positive values. Voltammetric results showed that NOV binds with cysteine forming 1:1 nonelectroactive molecular complex by means of electrostatic and hydrogen-bonding interactions. The binding constants of NOV with cysteine at pHs 5, 7 and 10 were calculated to be 3.06x10³, 1.54x10(4) and 1.06x10(5) M-1, respectively. Furthermore, apossible mechanism of such interaction was also discussed.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.54 n.1 20092009-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000100011en10.4067/S0717-97072009000100011
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Voltammetry Novobiocin Cysteine Interaction pH effect
spellingShingle	Voltammetry Novobiocin Cysteine Interaction pH effect BÇER,ENDER QETNKAYA,PAKZE A VOLTAMMETRIC STUDY ON THE INTERACTION OF NOVOBIOCIN WITH CYSTEINE
description	The interaction of novobiocin (NOV), an aminocoumarin antibiotic, with cysteine was studied by square-wave voltammetry technique on the hanging mercury drop electrode in different pH values. After the addition of NOV into the cysteine solution, the peak current of mercurous cysteine thiolate decreased and its voltammetric peak potential shifted to more positive values. Voltammetric results showed that NOV binds with cysteine forming 1:1 nonelectroactive molecular complex by means of electrostatic and hydrogen-bonding interactions. The binding constants of NOV with cysteine at pHs 5, 7 and 10 were calculated to be 3.06x10³, 1.54x10(4) and 1.06x10(5) M-1, respectively. Furthermore, apossible mechanism of such interaction was also discussed.
author	BÇER,ENDER QETNKAYA,PAKZE
author_facet	BÇER,ENDER QETNKAYA,PAKZE
author_sort	BÇER,ENDER
title	A VOLTAMMETRIC STUDY ON THE INTERACTION OF NOVOBIOCIN WITH CYSTEINE
title_short	A VOLTAMMETRIC STUDY ON THE INTERACTION OF NOVOBIOCIN WITH CYSTEINE
title_full	A VOLTAMMETRIC STUDY ON THE INTERACTION OF NOVOBIOCIN WITH CYSTEINE
title_fullStr	A VOLTAMMETRIC STUDY ON THE INTERACTION OF NOVOBIOCIN WITH CYSTEINE
title_full_unstemmed	A VOLTAMMETRIC STUDY ON THE INTERACTION OF NOVOBIOCIN WITH CYSTEINE
title_sort	voltammetric study on the interaction of novobiocin with cysteine
publisher	Sociedad Chilena de Química
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000100011
work_keys_str_mv	AT bcerender avoltammetricstudyontheinteractionofnovobiocinwithcysteine AT qetnkayapakze avoltammetricstudyontheinteractionofnovobiocinwithcysteine AT bcerender voltammetricstudyontheinteractionofnovobiocinwithcysteine AT qetnkayapakze voltammetricstudyontheinteractionofnovobiocinwithcysteine
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A VOLTAMMETRIC STUDY ON THE INTERACTION OF NOVOBIOCIN WITH CYSTEINE

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