ANTIMICROBIAL ACTIVITY OF EXTRACTS, ESSENTIAL OIL AND METABOLITES OBTAINED FROM TAGETES MENDOCINA

Extracts from the Argentinean herb Tagetes mendocina Phil. (Asteraceae) were tested for antimicrobial activity against fungi, bacteria and protozoa. The different extracts (PE, DCM, MeOH and EtOAc) and the essential oil displayed activity mainly against dermatophytes, a group of fungi that produces...

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Autores principales:	LIMA,BEATRIZ, AGÜERO,MARÍA BELÉN, ZYGADLO,JULIO, TAPIA,ALEJANDRO, SOLIS,CARLOS, ROJAS DE ARIAS,ANTONIETA, YALUFF,GLORIA, ZACCHINO,SUSANA, EGLY FERESIN,GABRIELA, SCHMEDA-HIRSCHMANN,GUILLERMO
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2009
Materias:	Tagetes mendocina antimicrobial activity essential oil analysis dermatophytes Leishmania spp. thiophenes
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000100016
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spelling	oai:scielo:S0717-970720090001000162009-05-12ANTIMICROBIAL ACTIVITY OF EXTRACTS, ESSENTIAL OIL AND METABOLITES OBTAINED FROM TAGETES MENDOCINALIMA,BEATRIZAGÜERO,MARÍA BELÉNZYGADLO,JULIOTAPIA,ALEJANDROSOLIS,CARLOSROJAS DE ARIAS,ANTONIETAYALUFF,GLORIAZACCHINO,SUSANAEGLY FERESIN,GABRIELASCHMEDA-HIRSCHMANN,GUILLERMO Tagetes mendocina antimicrobial activity essential oil analysis dermatophytes Leishmania spp. thiophenes Extracts from the Argentinean herb Tagetes mendocina Phil. (Asteraceae) were tested for antimicrobial activity against fungi, bacteria and protozoa. The different extracts (PE, DCM, MeOH and EtOAc) and the essential oil displayed activity mainly against dermatophytes, a group of fungi that produces skin infections. The bioassay-guided fractionation of PE, DCM and EtOAc extracts led to the isolation of eight compounds including two thiophenes, two acetophenone derivatives, dihydrorosefuran and three flavonoids. ITie thiophenes 5-(4-hydroxy- l-butynyl)-2,2'-bithienyl (BBTOH) (1) and its acetate (BBTOAc) (2) proved to be highly active against the dermatophytes Microsporum gypseum, Trichophyton rubrum and T. mentagrophytes with MIC values of 3.12, 3.12 and 6.25 µg/mL for compound 1 and 25, 3.12 and 6.25 µg/mLfor compound 2, respectively. In turn, the essential oil displayed a weak to modérate antifungal effect against M. gypseum with MIC = 250 µg/mL. ITie essential oil was examined by GC and GC-MS and 21 constituents (97.3%) were identified. (E) p-ocimene, (Z)-tagetone, (ii)-tagetone, (Z)-ocimenone, á-pinene and (E)-ocimenone were the major components. In addition, thiophenes 1 and 2 and 2-hydroxyacetophenone 3 showed antiprotozoal activity against Leishmania amazonensis, L. brasiliensis andi. infantum promastigotes with 100% lysis at 100 µg/mL.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.54 n.1 20092009-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000100016en10.4067/S0717-97072009000100016
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Tagetes mendocina antimicrobial activity essential oil analysis dermatophytes Leishmania spp. thiophenes
spellingShingle	Tagetes mendocina antimicrobial activity essential oil analysis dermatophytes Leishmania spp. thiophenes LIMA,BEATRIZ AGÜERO,MARÍA BELÉN ZYGADLO,JULIO TAPIA,ALEJANDRO SOLIS,CARLOS ROJAS DE ARIAS,ANTONIETA YALUFF,GLORIA ZACCHINO,SUSANA EGLY FERESIN,GABRIELA SCHMEDA-HIRSCHMANN,GUILLERMO ANTIMICROBIAL ACTIVITY OF EXTRACTS, ESSENTIAL OIL AND METABOLITES OBTAINED FROM TAGETES MENDOCINA
description	Extracts from the Argentinean herb Tagetes mendocina Phil. (Asteraceae) were tested for antimicrobial activity against fungi, bacteria and protozoa. The different extracts (PE, DCM, MeOH and EtOAc) and the essential oil displayed activity mainly against dermatophytes, a group of fungi that produces skin infections. The bioassay-guided fractionation of PE, DCM and EtOAc extracts led to the isolation of eight compounds including two thiophenes, two acetophenone derivatives, dihydrorosefuran and three flavonoids. ITie thiophenes 5-(4-hydroxy- l-butynyl)-2,2'-bithienyl (BBTOH) (1) and its acetate (BBTOAc) (2) proved to be highly active against the dermatophytes Microsporum gypseum, Trichophyton rubrum and T. mentagrophytes with MIC values of 3.12, 3.12 and 6.25 µg/mL for compound 1 and 25, 3.12 and 6.25 µg/mLfor compound 2, respectively. In turn, the essential oil displayed a weak to modérate antifungal effect against M. gypseum with MIC = 250 µg/mL. ITie essential oil was examined by GC and GC-MS and 21 constituents (97.3%) were identified. (E) p-ocimene, (Z)-tagetone, (ii)-tagetone, (Z)-ocimenone, á-pinene and (E)-ocimenone were the major components. In addition, thiophenes 1 and 2 and 2-hydroxyacetophenone 3 showed antiprotozoal activity against Leishmania amazonensis, L. brasiliensis andi. infantum promastigotes with 100% lysis at 100 µg/mL.
author	LIMA,BEATRIZ AGÜERO,MARÍA BELÉN ZYGADLO,JULIO TAPIA,ALEJANDRO SOLIS,CARLOS ROJAS DE ARIAS,ANTONIETA YALUFF,GLORIA ZACCHINO,SUSANA EGLY FERESIN,GABRIELA SCHMEDA-HIRSCHMANN,GUILLERMO
author_facet	LIMA,BEATRIZ AGÜERO,MARÍA BELÉN ZYGADLO,JULIO TAPIA,ALEJANDRO SOLIS,CARLOS ROJAS DE ARIAS,ANTONIETA YALUFF,GLORIA ZACCHINO,SUSANA EGLY FERESIN,GABRIELA SCHMEDA-HIRSCHMANN,GUILLERMO
author_sort	LIMA,BEATRIZ
title	ANTIMICROBIAL ACTIVITY OF EXTRACTS, ESSENTIAL OIL AND METABOLITES OBTAINED FROM TAGETES MENDOCINA
title_short	ANTIMICROBIAL ACTIVITY OF EXTRACTS, ESSENTIAL OIL AND METABOLITES OBTAINED FROM TAGETES MENDOCINA
title_full	ANTIMICROBIAL ACTIVITY OF EXTRACTS, ESSENTIAL OIL AND METABOLITES OBTAINED FROM TAGETES MENDOCINA
title_fullStr	ANTIMICROBIAL ACTIVITY OF EXTRACTS, ESSENTIAL OIL AND METABOLITES OBTAINED FROM TAGETES MENDOCINA
title_full_unstemmed	ANTIMICROBIAL ACTIVITY OF EXTRACTS, ESSENTIAL OIL AND METABOLITES OBTAINED FROM TAGETES MENDOCINA
title_sort	antimicrobial activity of extracts, essential oil and metabolites obtained from tagetes mendocina
publisher	Sociedad Chilena de Química
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000100016
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ANTIMICROBIAL ACTIVITY OF EXTRACTS, ESSENTIAL OIL AND METABOLITES OBTAINED FROM TAGETES MENDOCINA

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