IDENTIFICATION OF KURARINONE BY LC/MS AND INVESTIGATION OF ITS THERMAL STABILITY

A herbal ingredient kurannone (7, 2', 4,-trihydroxy-8-lavandulyl-5-methoxy flavanone) was isolated from the roots of sophoraflavescens Ait by ultrasonic extraction, which is one of tradicional Chinese medicine (TCM) materials. A reliable high performance liquid chromatography with mass spectrom...

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Autores principales:	LIU,PENGFEI, DENG,TIANSHENG, YE,CUIPING, QIN,ZHANGFENG, HOU,XIANGLIN, WANG,JIANGUO
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2009
Materias:	Sophoraflavescens Ait Leguminosae Flavonoids Kurarinone HPLC-ESI-MS Ultrasonic extraction Thermal stability
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000100019
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spelling	oai:scielo:S0717-970720090001000192009-05-12IDENTIFICATION OF KURARINONE BY LC/MS AND INVESTIGATION OF ITS THERMAL STABILITYLIU,PENGFEIDENG,TIANSHENGYE,CUIPINGQIN,ZHANGFENGHOU,XIANGLINWANG,JIANGUO Sophoraflavescens Ait Leguminosae Flavonoids Kurarinone HPLC-ESI-MS Ultrasonic extraction Thermal stability A herbal ingredient kurannone (7, 2', 4,-trihydroxy-8-lavandulyl-5-methoxy flavanone) was isolated from the roots of sophoraflavescens Ait by ultrasonic extraction, which is one of tradicional Chinese medicine (TCM) materials. A reliable high performance liquid chromatography with mass spectrometry (HPLC-MS) method was used for determination of kurarinone. C18 column (150x4.6 mm, 5 µm) and methanol-water mobile phase (70:30, by volume) were used in the chromatographic separation of active components from the herb. HPLC-ESI-MS (UV, 288 nm; m/z, 437.5 [M-H]-) was adopted for kurarinone identification. Kurarinone with purity of 95.5% was obtained by silica gel column foUowed by reverse-phase column chromatography. The thermal stability of kurarinone was investigated, which illustrates that kurarinone was stable below 25 °C in 48 h, but a degradation of 25.54% was observed at 80 °C for 2 h.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.54 n.1 20092009-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000100019en10.4067/S0717-97072009000100019
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Sophoraflavescens Ait Leguminosae Flavonoids Kurarinone HPLC-ESI-MS Ultrasonic extraction Thermal stability
spellingShingle	Sophoraflavescens Ait Leguminosae Flavonoids Kurarinone HPLC-ESI-MS Ultrasonic extraction Thermal stability LIU,PENGFEI DENG,TIANSHENG YE,CUIPING QIN,ZHANGFENG HOU,XIANGLIN WANG,JIANGUO IDENTIFICATION OF KURARINONE BY LC/MS AND INVESTIGATION OF ITS THERMAL STABILITY
description	A herbal ingredient kurannone (7, 2', 4,-trihydroxy-8-lavandulyl-5-methoxy flavanone) was isolated from the roots of sophoraflavescens Ait by ultrasonic extraction, which is one of tradicional Chinese medicine (TCM) materials. A reliable high performance liquid chromatography with mass spectrometry (HPLC-MS) method was used for determination of kurarinone. C18 column (150x4.6 mm, 5 µm) and methanol-water mobile phase (70:30, by volume) were used in the chromatographic separation of active components from the herb. HPLC-ESI-MS (UV, 288 nm; m/z, 437.5 [M-H]-) was adopted for kurarinone identification. Kurarinone with purity of 95.5% was obtained by silica gel column foUowed by reverse-phase column chromatography. The thermal stability of kurarinone was investigated, which illustrates that kurarinone was stable below 25 °C in 48 h, but a degradation of 25.54% was observed at 80 °C for 2 h.
author	LIU,PENGFEI DENG,TIANSHENG YE,CUIPING QIN,ZHANGFENG HOU,XIANGLIN WANG,JIANGUO
author_facet	LIU,PENGFEI DENG,TIANSHENG YE,CUIPING QIN,ZHANGFENG HOU,XIANGLIN WANG,JIANGUO
author_sort	LIU,PENGFEI
title	IDENTIFICATION OF KURARINONE BY LC/MS AND INVESTIGATION OF ITS THERMAL STABILITY
title_short	IDENTIFICATION OF KURARINONE BY LC/MS AND INVESTIGATION OF ITS THERMAL STABILITY
title_full	IDENTIFICATION OF KURARINONE BY LC/MS AND INVESTIGATION OF ITS THERMAL STABILITY
title_fullStr	IDENTIFICATION OF KURARINONE BY LC/MS AND INVESTIGATION OF ITS THERMAL STABILITY
title_full_unstemmed	IDENTIFICATION OF KURARINONE BY LC/MS AND INVESTIGATION OF ITS THERMAL STABILITY
title_sort	identification of kurarinone by lc/ms and investigation of its thermal stability
publisher	Sociedad Chilena de Química
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000100019
work_keys_str_mv	AT liupengfei identificationofkurarinonebylcmsandinvestigationofitsthermalstability AT dengtiansheng identificationofkurarinonebylcmsandinvestigationofitsthermalstability AT yecuiping identificationofkurarinonebylcmsandinvestigationofitsthermalstability AT qinzhangfeng identificationofkurarinonebylcmsandinvestigationofitsthermalstability AT houxianglin identificationofkurarinonebylcmsandinvestigationofitsthermalstability AT wangjianguo identificationofkurarinonebylcmsandinvestigationofitsthermalstability
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IDENTIFICATION OF KURARINONE BY LC/MS AND INVESTIGATION OF ITS THERMAL STABILITY

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