CYTOTOXICITY , SCAVENGING AND LIPID PEROXIDATION - INHIBITING ACTIVITIES OF 5,3´,4´-trihy-droxy - 7 - methoxyflavanone ISOLATED FROM HAPLOPAPPUS RIGIDUS
The cytotoxicity, scavenging and lipid peroxidation - inhibiting activities of 5,3 ',4'- trihydroxy - 7 - methoxyflavanone, isolated from Haplopappus rigidus Phil.(Asteraceae), were evaluated in a series of in vitro assays involving free radicals (ABTS, DPPH), ascorbate - induced rat liver...
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| Autores principales: | , , , |
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| Lenguaje: | English |
| Publicado: |
Sociedad Chilena de Química
2009
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| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000200001 |
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| Sumario: | The cytotoxicity, scavenging and lipid peroxidation - inhibiting activities of 5,3 ',4'- trihydroxy - 7 - methoxyflavanone, isolated from Haplopappus rigidus Phil.(Asteraceae), were evaluated in a series of in vitro assays involving free radicals (ABTS, DPPH), ascorbate - induced rat liver microsomal lipid peroxidation, and the cytotoxicities to three human tumor cell lines . 5,3',4'-trihydroxy - 7 - methoxyflavanone , at concentration of 0.3 mg/mL , elicited an 97.4 % scavenging effect on DPPH; TEAC 1.35mM on ABTS , preventing microsomal lipid peroxidation IC50 1.8 μM and ED50 3.23 - 5.66 ug/mL against three human tumor cell, indicating that the flavanone 5,3',4'-trihydroxy - 7 - methoxyflavanone was effectively cytotoxic , as well as free radicals scavenger and a good inhibitor of iron/ascorbate induced lipid peroxidation in a dose dependent manner. |
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