CYTOTOXICITY , SCAVENGING AND LIPID PEROXIDATION - INHIBITING ACTIVITIES OF 5,3´,4´-trihy-droxy - 7 - methoxyflavanone ISOLATED FROM HAPLOPAPPUS RIGIDUS

The cytotoxicity, scavenging and lipid peroxidation - inhibiting activities of 5,3 ',4'- trihydroxy - 7 - methoxyflavanone, isolated from Haplopappus rigidus Phil.(Asteraceae), were evaluated in a series of in vitro assays involving free radicals (ABTS, DPPH), ascorbate - induced rat liver...

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Autores principales:	MORALES,GLAUCO, PAREDES,ADRIAN, SIERRA,PATRICIA, LOYOLA,LUIS A
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2009
Materias:	Haplopappus rididus flavonoid 5,3 ',4'- trihydroxy - 7 - methoxyflavanone cytototoxic scavenging microsomal lipid peroxidation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000200001
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spelling	oai:scielo:S0717-970720090002000012009-10-07CYTOTOXICITY , SCAVENGING AND LIPID PEROXIDATION - INHIBITING ACTIVITIES OF 5,3´,4´-trihy-droxy - 7 - methoxyflavanone ISOLATED FROM HAPLOPAPPUS RIGIDUSMORALES,GLAUCOPAREDES,ADRIANSIERRA,PATRICIALOYOLA,LUIS A Haplopappus rididus flavonoid 5,3 ',4'- trihydroxy - 7 - methoxyflavanone cytototoxic scavenging microsomal lipid peroxidation The cytotoxicity, scavenging and lipid peroxidation - inhibiting activities of 5,3 ',4'- trihydroxy - 7 - methoxyflavanone, isolated from Haplopappus rigidus Phil.(Asteraceae), were evaluated in a series of in vitro assays involving free radicals (ABTS, DPPH), ascorbate - induced rat liver microsomal lipid peroxidation, and the cytotoxicities to three human tumor cell lines . 5,3',4'-trihydroxy - 7 - methoxyflavanone , at concentration of 0.3 mg/mL , elicited an 97.4 % scavenging effect on DPPH; TEAC 1.35mM on ABTS , preventing microsomal lipid peroxidation IC50 1.8 μM and ED50 3.23 - 5.66 ug/mL against three human tumor cell, indicating that the flavanone 5,3',4'-trihydroxy - 7 - methoxyflavanone was effectively cytotoxic , as well as free radicals scavenger and a good inhibitor of iron/ascorbate induced lipid peroxidation in a dose dependent manner.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.54 n.2 20092009-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000200001en10.4067/S0717-97072009000200001
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Haplopappus rididus flavonoid 5,3 ',4'- trihydroxy - 7 - methoxyflavanone cytototoxic scavenging microsomal lipid peroxidation
spellingShingle	Haplopappus rididus flavonoid 5,3 ',4'- trihydroxy - 7 - methoxyflavanone cytototoxic scavenging microsomal lipid peroxidation MORALES,GLAUCO PAREDES,ADRIAN SIERRA,PATRICIA LOYOLA,LUIS A CYTOTOXICITY , SCAVENGING AND LIPID PEROXIDATION - INHIBITING ACTIVITIES OF 5,3´,4´-trihy-droxy - 7 - methoxyflavanone ISOLATED FROM HAPLOPAPPUS RIGIDUS
description	The cytotoxicity, scavenging and lipid peroxidation - inhibiting activities of 5,3 ',4'- trihydroxy - 7 - methoxyflavanone, isolated from Haplopappus rigidus Phil.(Asteraceae), were evaluated in a series of in vitro assays involving free radicals (ABTS, DPPH), ascorbate - induced rat liver microsomal lipid peroxidation, and the cytotoxicities to three human tumor cell lines . 5,3',4'-trihydroxy - 7 - methoxyflavanone , at concentration of 0.3 mg/mL , elicited an 97.4 % scavenging effect on DPPH; TEAC 1.35mM on ABTS , preventing microsomal lipid peroxidation IC50 1.8 μM and ED50 3.23 - 5.66 ug/mL against three human tumor cell, indicating that the flavanone 5,3',4'-trihydroxy - 7 - methoxyflavanone was effectively cytotoxic , as well as free radicals scavenger and a good inhibitor of iron/ascorbate induced lipid peroxidation in a dose dependent manner.
author	MORALES,GLAUCO PAREDES,ADRIAN SIERRA,PATRICIA LOYOLA,LUIS A
author_facet	MORALES,GLAUCO PAREDES,ADRIAN SIERRA,PATRICIA LOYOLA,LUIS A
author_sort	MORALES,GLAUCO
title	CYTOTOXICITY , SCAVENGING AND LIPID PEROXIDATION - INHIBITING ACTIVITIES OF 5,3´,4´-trihy-droxy - 7 - methoxyflavanone ISOLATED FROM HAPLOPAPPUS RIGIDUS
title_short	CYTOTOXICITY , SCAVENGING AND LIPID PEROXIDATION - INHIBITING ACTIVITIES OF 5,3´,4´-trihy-droxy - 7 - methoxyflavanone ISOLATED FROM HAPLOPAPPUS RIGIDUS
title_full	CYTOTOXICITY , SCAVENGING AND LIPID PEROXIDATION - INHIBITING ACTIVITIES OF 5,3´,4´-trihy-droxy - 7 - methoxyflavanone ISOLATED FROM HAPLOPAPPUS RIGIDUS
title_fullStr	CYTOTOXICITY , SCAVENGING AND LIPID PEROXIDATION - INHIBITING ACTIVITIES OF 5,3´,4´-trihy-droxy - 7 - methoxyflavanone ISOLATED FROM HAPLOPAPPUS RIGIDUS
title_full_unstemmed	CYTOTOXICITY , SCAVENGING AND LIPID PEROXIDATION - INHIBITING ACTIVITIES OF 5,3´,4´-trihy-droxy - 7 - methoxyflavanone ISOLATED FROM HAPLOPAPPUS RIGIDUS
title_sort	cytotoxicity , scavenging and lipid peroxidation - inhibiting activities of 5,3´,4´-trihy-droxy - 7 - methoxyflavanone isolated from haplopappus rigidus
publisher	Sociedad Chilena de Química
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000200001
work_keys_str_mv	AT moralesglauco cytotoxicityscavengingandlipidperoxidationinhibitingactivitiesof534trihydroxy7methoxyflavanoneisolatedfromhaplopappusrigidus AT paredesadrian cytotoxicityscavengingandlipidperoxidationinhibitingactivitiesof534trihydroxy7methoxyflavanoneisolatedfromhaplopappusrigidus AT sierrapatricia cytotoxicityscavengingandlipidperoxidationinhibitingactivitiesof534trihydroxy7methoxyflavanoneisolatedfromhaplopappusrigidus AT loyolaluisa cytotoxicityscavengingandlipidperoxidationinhibitingactivitiesof534trihydroxy7methoxyflavanoneisolatedfromhaplopappusrigidus
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CYTOTOXICITY , SCAVENGING AND LIPID PEROXIDATION - INHIBITING ACTIVITIES OF 5,3´,4´-trihy-droxy - 7 - methoxyflavanone ISOLATED FROM HAPLOPAPPUS RIGIDUS

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