THERMODYNAMIC CHARACTERIZATION OF DEXAMETHASONE SODIUM PHOSPHATE AND ITS COMPLEX WITH DNA AS STUDIED BY CONDUCTOMETRIC AND SPECTROSCOPIC TECHNIQUES

Electrical conductivities were measured to calculate critical aggregation concentration (cac) of dexamethasone sodium phosphate (DSP) at various temperature from 298-313K with an increment of 5 K and in this way its thermodynamic parameters like Gibbs energy of aggregation ( ΔGagg), enthalp...

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Autores principales:	SHAH,AFZAL, KHAN,ASAD M, USMAN,MUHAMMAD, QURESHl,RUMANA, SIDDIQ,MUHAMMAD, SHAH,SYED S
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2009
Materias:	dexamethasone conductivity binding constant DNA spectroscopy aggregation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000200007
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spelling	oai:scielo:S0717-970720090002000072009-10-07THERMODYNAMIC CHARACTERIZATION OF DEXAMETHASONE SODIUM PHOSPHATE AND ITS COMPLEX WITH DNA AS STUDIED BY CONDUCTOMETRIC AND SPECTROSCOPIC TECHNIQUESSHAH,AFZALKHAN,ASAD MUSMAN,MUHAMMADQURESHl,RUMANASIDDIQ,MUHAMMADSHAH,SYED S dexamethasone conductivity binding constant DNA spectroscopy aggregation Electrical conductivities were measured to calculate critical aggregation concentration (cac) of dexamethasone sodium phosphate (DSP) at various temperature from 298-313K with an increment of 5 K and in this way its thermodynamic parameters like Gibbs energy of aggregation ( ΔGagg), enthalpy of aggregation (ΔHagg ) and entropy of aggregation (ΔSagg) were estimated. The results demonstrate that DSP forms enthalpy driven aggregates through open association process. Furthermore, its interaction with DNA was studied by UV-Vis spectroscopy. The binding constant of DSP-DNA interaction was evaluated at 298 K and 310 K. Gibbs energy of drug-DNAcomplexation was determined by ΔG= -RT 1n k b , enthalpy of its interaction (ΔH) and entropy of adduct formation (ΔS) were obtained from Van't Hoff equation.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.54 n.2 20092009-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000200007en10.4067/S0717-97072009000200007
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	dexamethasone conductivity binding constant DNA spectroscopy aggregation
spellingShingle	dexamethasone conductivity binding constant DNA spectroscopy aggregation SHAH,AFZAL KHAN,ASAD M USMAN,MUHAMMAD QURESHl,RUMANA SIDDIQ,MUHAMMAD SHAH,SYED S THERMODYNAMIC CHARACTERIZATION OF DEXAMETHASONE SODIUM PHOSPHATE AND ITS COMPLEX WITH DNA AS STUDIED BY CONDUCTOMETRIC AND SPECTROSCOPIC TECHNIQUES
description	Electrical conductivities were measured to calculate critical aggregation concentration (cac) of dexamethasone sodium phosphate (DSP) at various temperature from 298-313K with an increment of 5 K and in this way its thermodynamic parameters like Gibbs energy of aggregation ( ΔGagg), enthalpy of aggregation (ΔHagg ) and entropy of aggregation (ΔSagg) were estimated. The results demonstrate that DSP forms enthalpy driven aggregates through open association process. Furthermore, its interaction with DNA was studied by UV-Vis spectroscopy. The binding constant of DSP-DNA interaction was evaluated at 298 K and 310 K. Gibbs energy of drug-DNAcomplexation was determined by ΔG= -RT 1n k b , enthalpy of its interaction (ΔH) and entropy of adduct formation (ΔS) were obtained from Van't Hoff equation.
author	SHAH,AFZAL KHAN,ASAD M USMAN,MUHAMMAD QURESHl,RUMANA SIDDIQ,MUHAMMAD SHAH,SYED S
author_facet	SHAH,AFZAL KHAN,ASAD M USMAN,MUHAMMAD QURESHl,RUMANA SIDDIQ,MUHAMMAD SHAH,SYED S
author_sort	SHAH,AFZAL
title	THERMODYNAMIC CHARACTERIZATION OF DEXAMETHASONE SODIUM PHOSPHATE AND ITS COMPLEX WITH DNA AS STUDIED BY CONDUCTOMETRIC AND SPECTROSCOPIC TECHNIQUES
title_short	THERMODYNAMIC CHARACTERIZATION OF DEXAMETHASONE SODIUM PHOSPHATE AND ITS COMPLEX WITH DNA AS STUDIED BY CONDUCTOMETRIC AND SPECTROSCOPIC TECHNIQUES
title_full	THERMODYNAMIC CHARACTERIZATION OF DEXAMETHASONE SODIUM PHOSPHATE AND ITS COMPLEX WITH DNA AS STUDIED BY CONDUCTOMETRIC AND SPECTROSCOPIC TECHNIQUES
title_fullStr	THERMODYNAMIC CHARACTERIZATION OF DEXAMETHASONE SODIUM PHOSPHATE AND ITS COMPLEX WITH DNA AS STUDIED BY CONDUCTOMETRIC AND SPECTROSCOPIC TECHNIQUES
title_full_unstemmed	THERMODYNAMIC CHARACTERIZATION OF DEXAMETHASONE SODIUM PHOSPHATE AND ITS COMPLEX WITH DNA AS STUDIED BY CONDUCTOMETRIC AND SPECTROSCOPIC TECHNIQUES
title_sort	thermodynamic characterization of dexamethasone sodium phosphate and its complex with dna as studied by conductometric and spectroscopic techniques
publisher	Sociedad Chilena de Química
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000200007
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_version_	1718445402358808576

THERMODYNAMIC CHARACTERIZATION OF DEXAMETHASONE SODIUM PHOSPHATE AND ITS COMPLEX WITH DNA AS STUDIED BY CONDUCTOMETRIC AND SPECTROSCOPIC TECHNIQUES

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