SYNTHESIS OF NOVEL TRYPTOPHAN DERIVATIVES OF POTENTIAL BIOLOGICAL ACTIVITY

SYNTHESIS OF NOVEL TRYPTOPHAN DERIVATIVES OF POTENTIAL BIOLOGICAL ACTIVITY

Tryptophan methyl ester 2 reacts with ethyl cyanoacetate to form acetomtrilocarbonyltryptophan methylester 3. The latter reacts with cyanomethylene reagents, hydrazines, cyanomethylenes and sulfur to form the corresponding a-pyrido-3-indolopropanoate derivatives 6a,b, pyrazolyltryptophan methyl este...

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Autores principales: MOHAREB,RAFAT M, LOUCA,NADIA A, ELMEGEED,GAMAL A, HANA,HANAA Y
Lenguaje:English
Publicado: Sociedad Chilena de Química 2009
Materias:
Teyptophane
pyrazd
pyridine
1,3- oxazine
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000200018
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spelling oai:scielo:S0717-970720090002000182009-10-07SYNTHESIS OF NOVEL TRYPTOPHAN DERIVATIVES OF POTENTIAL BIOLOGICAL ACTIVITYMOHAREB,RAFAT MLOUCA,NADIA AELMEGEED,GAMAL AHANA,HANAA Y Teyptophane pyrazd pyridine 1,3- oxazine Tryptophan methyl ester 2 reacts with ethyl cyanoacetate to form acetomtrilocarbonyltryptophan methylester 3. The latter reacts with cyanomethylene reagents, hydrazines, cyanomethylenes and sulfur to form the corresponding a-pyrido-3-indolopropanoate derivatives 6a,b, pyrazolyltryptophan methyl ester derivatives 8a,b and thiophenotryptophan methyl ester derivatives 10a,b, respectively. Also compound 3 reacts with benzaldehyde to give the condensated product 12. The reactivity of the latter product towards chemical reagents was studied to form pyridine, pyrazole and isoxazole derivatives.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.54 n.2 20092009-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000200018en10.4067/S0717-97072009000200018
institution Scielo Chile
collection Scielo Chile
language English
topic Teyptophane
pyrazd
pyridine
1,3- oxazine
spellingShingle Teyptophane
pyrazd
pyridine
1,3- oxazine
MOHAREB,RAFAT M
LOUCA,NADIA A
ELMEGEED,GAMAL A
HANA,HANAA Y
SYNTHESIS OF NOVEL TRYPTOPHAN DERIVATIVES OF POTENTIAL BIOLOGICAL ACTIVITY
description Tryptophan methyl ester 2 reacts with ethyl cyanoacetate to form acetomtrilocarbonyltryptophan methylester 3. The latter reacts with cyanomethylene reagents, hydrazines, cyanomethylenes and sulfur to form the corresponding a-pyrido-3-indolopropanoate derivatives 6a,b, pyrazolyltryptophan methyl ester derivatives 8a,b and thiophenotryptophan methyl ester derivatives 10a,b, respectively. Also compound 3 reacts with benzaldehyde to give the condensated product 12. The reactivity of the latter product towards chemical reagents was studied to form pyridine, pyrazole and isoxazole derivatives.
author MOHAREB,RAFAT M
LOUCA,NADIA A
ELMEGEED,GAMAL A
HANA,HANAA Y
author_facet MOHAREB,RAFAT M
LOUCA,NADIA A
ELMEGEED,GAMAL A
HANA,HANAA Y
author_sort MOHAREB,RAFAT M
title SYNTHESIS OF NOVEL TRYPTOPHAN DERIVATIVES OF POTENTIAL BIOLOGICAL ACTIVITY
title_short SYNTHESIS OF NOVEL TRYPTOPHAN DERIVATIVES OF POTENTIAL BIOLOGICAL ACTIVITY
title_full SYNTHESIS OF NOVEL TRYPTOPHAN DERIVATIVES OF POTENTIAL BIOLOGICAL ACTIVITY
title_fullStr SYNTHESIS OF NOVEL TRYPTOPHAN DERIVATIVES OF POTENTIAL BIOLOGICAL ACTIVITY
title_full_unstemmed SYNTHESIS OF NOVEL TRYPTOPHAN DERIVATIVES OF POTENTIAL BIOLOGICAL ACTIVITY
title_sort synthesis of novel tryptophan derivatives of potential biological activity
publisher Sociedad Chilena de Química
publishDate 2009
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000200018
work_keys_str_mv AT moharebrafatm synthesisofnoveltryptophanderivativesofpotentialbiologicalactivity
AT loucanadiaa synthesisofnoveltryptophanderivativesofpotentialbiologicalactivity
AT elmegeedgamala synthesisofnoveltryptophanderivativesofpotentialbiologicalactivity
AT hanahanaay synthesisofnoveltryptophanderivativesofpotentialbiologicalactivity
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