IMPROVEMENT OF GALANGIN SOLUBILITY USING NATIVE AND DERIVATIVE CYCLODEXTRINS: AN UV-Vis AND NMR STUDY
The slightly water-soluble flavonoid galangin (G) and its inclusion with either β-cyclodextrin (βCD), hydro xypropyl-β-cyclodextrin (HPβCD) or Heptakis-2,6-O-di methyl-β-cyclodextrin (DMβCD) were investigated. The stoichiometric ratios and stabil...
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| Lenguaje: | English |
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Sociedad Chilena de Química
2009
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| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000200025 |
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| Sumario: | The slightly water-soluble flavonoid galangin (G) and its inclusion with either β-cyclodextrin (βCD), hydro xypropyl-β-cyclodextrin (HPβCD) or Heptakis-2,6-O-di methyl-β-cyclodextrin (DMβCD) were investigated. The stoichiometric ratios and stability constants describing the extent of the formation of the complexes have been determined by phase-solubility measurements; in all cases type-A L diagrams have been obtained (soluble 1:1 complexes). The results showed that the complex efficiency of βCD and its derivatives was the order: DMβCD > HPβCD > βCD. The NMR study indicate that the inclusion of galangin in the cyclodextrin nano-cavity is different depending on the type of cyclodextrin used. |
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