SIMULTANEOUS QUANTITATION OF OLMESARTAN MEDOXOMIL AND AMLODIPINE BESYLATE IN COMBINED TABLETS USING HPLC

A simple, sensitive and isocratic reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous determination of olmesartan medoxomil and amlodipine in pharmaceutical tablet formulations. HPLC analysis was carried out using reverse phase isocratic elu...

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Autores principales:	QUTAB,SYED SHANAZ, RAZZAQ,SYED NAEEM, ASHFAQ,MUHAMMAD, KHAN,ISLAM ULLAH, MUMTAZ,AHMAD MAHMOOD
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2009
Materias:	HPLC acetonitrile olmesartan amlodipine
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000300007
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spelling	oai:scielo:S0717-970720090003000072010-03-17SIMULTANEOUS QUANTITATION OF OLMESARTAN MEDOXOMIL AND AMLODIPINE BESYLATE IN COMBINED TABLETS USING HPLCQUTAB,SYED SHANAZRAZZAQ,SYED NAEEMASHFAQ,MUHAMMADKHAN,ISLAM ULLAHMUMTAZ,AHMAD MAHMOOD HPLC acetonitrile olmesartan amlodipine A simple, sensitive and isocratic reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous determination of olmesartan medoxomil and amlodipine in pharmaceutical tablet formulations. HPLC analysis was carried out using reverse phase isocratic elution with aC18 column and amobilephase of 0.05 Mammonium acetate pH 6.8 and acetonitrile intheratio of 40:60, v/v. Detection of the analytes was achieved using UV detector at 239 nm. The retention times of olmesartan medoxomil and amlodipine were 2.50 and 3.94 respectively Linearity of the method was found to be in the concentration range of 16-112 µgml-1 for olmesartan medoximil and 4-28 µgml-1 for amlodipine. The correlation coefficient value was greaterthan 0.9999 for both the analytes. The method is suitable for the estimation of both the components simultaneously in pharmaceutical tablet formulations.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.54 n.3 20092009-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000300007en10.4067/S0717-97072009000300007
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	HPLC acetonitrile olmesartan amlodipine
spellingShingle	HPLC acetonitrile olmesartan amlodipine QUTAB,SYED SHANAZ RAZZAQ,SYED NAEEM ASHFAQ,MUHAMMAD KHAN,ISLAM ULLAH MUMTAZ,AHMAD MAHMOOD SIMULTANEOUS QUANTITATION OF OLMESARTAN MEDOXOMIL AND AMLODIPINE BESYLATE IN COMBINED TABLETS USING HPLC
description	A simple, sensitive and isocratic reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous determination of olmesartan medoxomil and amlodipine in pharmaceutical tablet formulations. HPLC analysis was carried out using reverse phase isocratic elution with aC18 column and amobilephase of 0.05 Mammonium acetate pH 6.8 and acetonitrile intheratio of 40:60, v/v. Detection of the analytes was achieved using UV detector at 239 nm. The retention times of olmesartan medoxomil and amlodipine were 2.50 and 3.94 respectively Linearity of the method was found to be in the concentration range of 16-112 µgml-1 for olmesartan medoximil and 4-28 µgml-1 for amlodipine. The correlation coefficient value was greaterthan 0.9999 for both the analytes. The method is suitable for the estimation of both the components simultaneously in pharmaceutical tablet formulations.
author	QUTAB,SYED SHANAZ RAZZAQ,SYED NAEEM ASHFAQ,MUHAMMAD KHAN,ISLAM ULLAH MUMTAZ,AHMAD MAHMOOD
author_facet	QUTAB,SYED SHANAZ RAZZAQ,SYED NAEEM ASHFAQ,MUHAMMAD KHAN,ISLAM ULLAH MUMTAZ,AHMAD MAHMOOD
author_sort	QUTAB,SYED SHANAZ
title	SIMULTANEOUS QUANTITATION OF OLMESARTAN MEDOXOMIL AND AMLODIPINE BESYLATE IN COMBINED TABLETS USING HPLC
title_short	SIMULTANEOUS QUANTITATION OF OLMESARTAN MEDOXOMIL AND AMLODIPINE BESYLATE IN COMBINED TABLETS USING HPLC
title_full	SIMULTANEOUS QUANTITATION OF OLMESARTAN MEDOXOMIL AND AMLODIPINE BESYLATE IN COMBINED TABLETS USING HPLC
title_fullStr	SIMULTANEOUS QUANTITATION OF OLMESARTAN MEDOXOMIL AND AMLODIPINE BESYLATE IN COMBINED TABLETS USING HPLC
title_full_unstemmed	SIMULTANEOUS QUANTITATION OF OLMESARTAN MEDOXOMIL AND AMLODIPINE BESYLATE IN COMBINED TABLETS USING HPLC
title_sort	simultaneous quantitation of olmesartan medoxomil and amlodipine besylate in combined tablets using hplc
publisher	Sociedad Chilena de Química
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000300007
work_keys_str_mv	AT qutabsyedshanaz simultaneousquantitationofolmesartanmedoxomilandamlodipinebesylateincombinedtabletsusinghplc AT razzaqsyednaeem simultaneousquantitationofolmesartanmedoxomilandamlodipinebesylateincombinedtabletsusinghplc AT ashfaqmuhammad simultaneousquantitationofolmesartanmedoxomilandamlodipinebesylateincombinedtabletsusinghplc AT khanislamullah simultaneousquantitationofolmesartanmedoxomilandamlodipinebesylateincombinedtabletsusinghplc AT mumtazahmadmahmood simultaneousquantitationofolmesartanmedoxomilandamlodipinebesylateincombinedtabletsusinghplc
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SIMULTANEOUS QUANTITATION OF OLMESARTAN MEDOXOMIL AND AMLODIPINE BESYLATE IN COMBINED TABLETS USING HPLC

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