DIRECT ORTHOGONAL SIGNAL CORRECTION-PARTIAL LEAST SQUARES FOR SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF SULFAMETHOXAZOLE AND TRIMETHOPRIM IN PHARMACEUTICAL FORMULATION AND SYNTHETIC SAMPLES

This work describes a very simple, novel and selective spectrophotmetric method for simultaneous determination of sulfamethoxazole and trimethoprim in pharmaceutical preparation and synthetics samples using direct orthogonal signal correction-partial least squares (DOSC-PLS). The all factors affecti...

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Autores principales:	GOODARZI,MOHAMMAD, SHAHBAZIKHAH,PARVIZ, REZA SOHRABI,MAHMOUD, FATHABADI,MOZHGAN, HASSAN NOURI,SAREZOO
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2009
Materias:	Sulfamethoxazole Trimethoprim Spectrophotometric PLS DOSC-PLS
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000300022
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spelling	oai:scielo:S0717-970720090003000222010-03-17DIRECT ORTHOGONAL SIGNAL CORRECTION-PARTIAL LEAST SQUARES FOR SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF SULFAMETHOXAZOLE AND TRIMETHOPRIM IN PHARMACEUTICAL FORMULATION AND SYNTHETIC SAMPLESGOODARZI,MOHAMMADSHAHBAZIKHAH,PARVIZREZA SOHRABI,MAHMOUDFATHABADI,MOZHGANHASSAN NOURI,SAREZOO Sulfamethoxazole Trimethoprim Spectrophotometric PLS DOSC-PLS This work describes a very simple, novel and selective spectrophotmetric method for simultaneous determination of sulfamethoxazole and trimethoprim in pharmaceutical preparation and synthetics samples using direct orthogonal signal correction-partial least squares (DOSC-PLS). The all factors affecting on the sensitivity were optimized and the linear dynamic range for determining of these drugs was found. The PLS modeling was used for the multivariate calibration of the spectrophotometric data and DOSC was used for preprocessing of data matrices and the prediction results of model. The experimental calibration matrix was designed by measuring the absorbance over the range 200-400 nm for 32 samples of 2.0-15.0 and 0.4-6.0 µg mL-1 of sulfamethoxazole and trimethoprim, respectively. The root mean square error of prediction for sulfamethoxazole and trimethoprim using DOSC-PLS and PLS were 0.02212, 0.02363 and 0.17014, 0.01660, µg mL-1 respectively. Application of the method to synthetic samples of standard solutions and in pharmaceutical formulation was performed and satisfactory results were obtained.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.54 n.3 20092009-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000300022en10.4067/S0717-97072009000300022
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Sulfamethoxazole Trimethoprim Spectrophotometric PLS DOSC-PLS
spellingShingle	Sulfamethoxazole Trimethoprim Spectrophotometric PLS DOSC-PLS GOODARZI,MOHAMMAD SHAHBAZIKHAH,PARVIZ REZA SOHRABI,MAHMOUD FATHABADI,MOZHGAN HASSAN NOURI,SAREZOO DIRECT ORTHOGONAL SIGNAL CORRECTION-PARTIAL LEAST SQUARES FOR SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF SULFAMETHOXAZOLE AND TRIMETHOPRIM IN PHARMACEUTICAL FORMULATION AND SYNTHETIC SAMPLES
description	This work describes a very simple, novel and selective spectrophotmetric method for simultaneous determination of sulfamethoxazole and trimethoprim in pharmaceutical preparation and synthetics samples using direct orthogonal signal correction-partial least squares (DOSC-PLS). The all factors affecting on the sensitivity were optimized and the linear dynamic range for determining of these drugs was found. The PLS modeling was used for the multivariate calibration of the spectrophotometric data and DOSC was used for preprocessing of data matrices and the prediction results of model. The experimental calibration matrix was designed by measuring the absorbance over the range 200-400 nm for 32 samples of 2.0-15.0 and 0.4-6.0 µg mL-1 of sulfamethoxazole and trimethoprim, respectively. The root mean square error of prediction for sulfamethoxazole and trimethoprim using DOSC-PLS and PLS were 0.02212, 0.02363 and 0.17014, 0.01660, µg mL-1 respectively. Application of the method to synthetic samples of standard solutions and in pharmaceutical formulation was performed and satisfactory results were obtained.
author	GOODARZI,MOHAMMAD SHAHBAZIKHAH,PARVIZ REZA SOHRABI,MAHMOUD FATHABADI,MOZHGAN HASSAN NOURI,SAREZOO
author_facet	GOODARZI,MOHAMMAD SHAHBAZIKHAH,PARVIZ REZA SOHRABI,MAHMOUD FATHABADI,MOZHGAN HASSAN NOURI,SAREZOO
author_sort	GOODARZI,MOHAMMAD
title	DIRECT ORTHOGONAL SIGNAL CORRECTION-PARTIAL LEAST SQUARES FOR SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF SULFAMETHOXAZOLE AND TRIMETHOPRIM IN PHARMACEUTICAL FORMULATION AND SYNTHETIC SAMPLES
title_short	DIRECT ORTHOGONAL SIGNAL CORRECTION-PARTIAL LEAST SQUARES FOR SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF SULFAMETHOXAZOLE AND TRIMETHOPRIM IN PHARMACEUTICAL FORMULATION AND SYNTHETIC SAMPLES
title_full	DIRECT ORTHOGONAL SIGNAL CORRECTION-PARTIAL LEAST SQUARES FOR SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF SULFAMETHOXAZOLE AND TRIMETHOPRIM IN PHARMACEUTICAL FORMULATION AND SYNTHETIC SAMPLES
title_fullStr	DIRECT ORTHOGONAL SIGNAL CORRECTION-PARTIAL LEAST SQUARES FOR SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF SULFAMETHOXAZOLE AND TRIMETHOPRIM IN PHARMACEUTICAL FORMULATION AND SYNTHETIC SAMPLES
title_full_unstemmed	DIRECT ORTHOGONAL SIGNAL CORRECTION-PARTIAL LEAST SQUARES FOR SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF SULFAMETHOXAZOLE AND TRIMETHOPRIM IN PHARMACEUTICAL FORMULATION AND SYNTHETIC SAMPLES
title_sort	direct orthogonal signal correction-partial least squares for simultaneous spectrophotometric determination of sulfamethoxazole and trimethoprim in pharmaceutical formulation and synthetic samples
publisher	Sociedad Chilena de Química
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000300022
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DIRECT ORTHOGONAL SIGNAL CORRECTION-PARTIAL LEAST SQUARES FOR SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF SULFAMETHOXAZOLE AND TRIMETHOPRIM IN PHARMACEUTICAL FORMULATION AND SYNTHETIC SAMPLES

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