INVESTIGATIONS ON NUCLEASE ACTIVITY OF TRANS MIXED LIGAND- COPPER(II) COMPLEXES WITH ORTHO SUBSTITUTED AROMATIC OXIMES AND HETEROCYCLIC BASES

Mixed ligand complexes of copper(II) with salicyladoxime (SAO), 2-hydroxy acetophenone oxime (HAO) as primary ligands and pyridine( Py), imidazole (Im) as secondary ligands have been synthesized and characterized by molar conductivity, magnetic moments, electronic, IR and ESR spectral data. Cyclic v...

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Autores principales:	SURENDRA BABU,M.S, KRISHNA,PITCHIKA.G, HUSSAIN REDDY,K, PHILIP,G.H
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2009
Materias:	Copper(II) complexes mixed ligand complexes aromatic oximes DNA binding oxidative cleavage
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400003
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spelling	oai:scielo:S0717-970720090004000032010-04-15INVESTIGATIONS ON NUCLEASE ACTIVITY OF TRANS MIXED LIGAND- COPPER(II) COMPLEXES WITH ORTHO SUBSTITUTED AROMATIC OXIMES AND HETEROCYCLIC BASESSURENDRA BABU,M.SKRISHNA,PITCHIKA.GHUSSAIN REDDY,KPHILIP,G.H Copper(II) complexes mixed ligand complexes aromatic oximes DNA binding oxidative cleavage Mixed ligand complexes of copper(II) with salicyladoxime (SAO), 2-hydroxy acetophenone oxime (HAO) as primary ligands and pyridine( Py), imidazole (Im) as secondary ligands have been synthesized and characterized by molar conductivity, magnetic moments, electronic, IR and ESR spectral data. Cyclic voltammetric studies show quasi-reversible reduction attributable to Cu2+/ Cu+. The binding interactions between metal complexes and calf thymus DNA have been investigated by using UV -Visible titrations and cyclic voltammetry studies. The cleavage activity of complexes was carried out on double-stranded pBR322 circular plasmid DNA by using gel electrophoresis. All complexes show increased nuclease activity in the presence of oxidant (H(2)0(2)). The nuclease activity of mixed ligand complexes are compared with that of the parent copper(II) complexes. Controlled experiments suggest that the complexes cleave DNA predominantly via an oxidative mechanism.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.54 n.4 20092009-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400003en10.4067/S0717-97072009000400003
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Copper(II) complexes mixed ligand complexes aromatic oximes DNA binding oxidative cleavage
spellingShingle	Copper(II) complexes mixed ligand complexes aromatic oximes DNA binding oxidative cleavage SURENDRA BABU,M.S KRISHNA,PITCHIKA.G HUSSAIN REDDY,K PHILIP,G.H INVESTIGATIONS ON NUCLEASE ACTIVITY OF TRANS MIXED LIGAND- COPPER(II) COMPLEXES WITH ORTHO SUBSTITUTED AROMATIC OXIMES AND HETEROCYCLIC BASES
description	Mixed ligand complexes of copper(II) with salicyladoxime (SAO), 2-hydroxy acetophenone oxime (HAO) as primary ligands and pyridine( Py), imidazole (Im) as secondary ligands have been synthesized and characterized by molar conductivity, magnetic moments, electronic, IR and ESR spectral data. Cyclic voltammetric studies show quasi-reversible reduction attributable to Cu2+/ Cu+. The binding interactions between metal complexes and calf thymus DNA have been investigated by using UV -Visible titrations and cyclic voltammetry studies. The cleavage activity of complexes was carried out on double-stranded pBR322 circular plasmid DNA by using gel electrophoresis. All complexes show increased nuclease activity in the presence of oxidant (H(2)0(2)). The nuclease activity of mixed ligand complexes are compared with that of the parent copper(II) complexes. Controlled experiments suggest that the complexes cleave DNA predominantly via an oxidative mechanism.
author	SURENDRA BABU,M.S KRISHNA,PITCHIKA.G HUSSAIN REDDY,K PHILIP,G.H
author_facet	SURENDRA BABU,M.S KRISHNA,PITCHIKA.G HUSSAIN REDDY,K PHILIP,G.H
author_sort	SURENDRA BABU,M.S
title	INVESTIGATIONS ON NUCLEASE ACTIVITY OF TRANS MIXED LIGAND- COPPER(II) COMPLEXES WITH ORTHO SUBSTITUTED AROMATIC OXIMES AND HETEROCYCLIC BASES
title_short	INVESTIGATIONS ON NUCLEASE ACTIVITY OF TRANS MIXED LIGAND- COPPER(II) COMPLEXES WITH ORTHO SUBSTITUTED AROMATIC OXIMES AND HETEROCYCLIC BASES
title_full	INVESTIGATIONS ON NUCLEASE ACTIVITY OF TRANS MIXED LIGAND- COPPER(II) COMPLEXES WITH ORTHO SUBSTITUTED AROMATIC OXIMES AND HETEROCYCLIC BASES
title_fullStr	INVESTIGATIONS ON NUCLEASE ACTIVITY OF TRANS MIXED LIGAND- COPPER(II) COMPLEXES WITH ORTHO SUBSTITUTED AROMATIC OXIMES AND HETEROCYCLIC BASES
title_full_unstemmed	INVESTIGATIONS ON NUCLEASE ACTIVITY OF TRANS MIXED LIGAND- COPPER(II) COMPLEXES WITH ORTHO SUBSTITUTED AROMATIC OXIMES AND HETEROCYCLIC BASES
title_sort	investigations on nuclease activity of trans mixed ligand- copper(ii) complexes with ortho substituted aromatic oximes and heterocyclic bases
publisher	Sociedad Chilena de Química
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400003
work_keys_str_mv	AT surendrababums investigationsonnucleaseactivityoftransmixedligandcopperiicomplexeswithorthosubstitutedaromaticoximesandheterocyclicbases AT krishnapitchikag investigationsonnucleaseactivityoftransmixedligandcopperiicomplexeswithorthosubstitutedaromaticoximesandheterocyclicbases AT hussainreddyk investigationsonnucleaseactivityoftransmixedligandcopperiicomplexeswithorthosubstitutedaromaticoximesandheterocyclicbases AT philipgh investigationsonnucleaseactivityoftransmixedligandcopperiicomplexeswithorthosubstitutedaromaticoximesandheterocyclicbases
_version_	1718445410937208832

INVESTIGATIONS ON NUCLEASE ACTIVITY OF TRANS MIXED LIGAND- COPPER(II) COMPLEXES WITH ORTHO SUBSTITUTED AROMATIC OXIMES AND HETEROCYCLIC BASES

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