SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL SCHIFF BASE COPPER(II) COMPLEXES

Five novel copper(II) complexes have been synthesized using Schiff base ligands, synthesized by the condensation reaction of anthranilic acid and Knoevenagel β-ketoanilide condensates (obtained by the condensation of acetoacetanilide and substituted benzaldehydes). The ligands and copper(II...

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Autores principales:	RAMAN,N, JOSEPH,J, SAKTHIVEL,A, JEYAMURUGAN,R
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2009
Materias:	Schiff base ligands square-planar Knoevenagel
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400006
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spelling	oai:scielo:S0717-970720090004000062010-04-15SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL SCHIFF BASE COPPER(II) COMPLEXESRAMAN,NJOSEPH,JSAKTHIVEL,AJEYAMURUGAN,R Schiff base ligands square-planar Knoevenagel Five novel copper(II) complexes have been synthesized using Schiff base ligands, synthesized by the condensation reaction of anthranilic acid and Knoevenagel β-ketoanilide condensates (obtained by the condensation of acetoacetanilide and substituted benzaldehydes). The ligands and copper(II) complexes have been characterized on the basis of Microanalytical, Mass, UV-Vis., IR, 'H NMR, ESR, XRD and CV spectral studies, as well as magnetic susceptibility and conductivity data. On the basis of spectral studies, a square-planar geometry has been proposed for the copper(II) complexes. From the XRD data, the CuL-1 complex has the crystallite size of 50 nm respectively. The in vitro antimicrobial activity of the compounds is tested against the bacteria Escherichia coli, Salmonella typhi, Staphylococcus aureus, Klebsiella pneumoniae and Pseudonomas aeruginosa and fungi Aspergillus niger, Rhizopus stolonifer, Aspergillus flavus, Rhizoctonia bataicola and Candida albicans by well diffusion method. The complexes show stronger antimicrobial activity than the free ligands. They represent a novel class of metal-based antimicrobial agents which provide opportunities for a large number of synthetic variations for modulation of the activities.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.54 n.4 20092009-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400006en10.4067/S0717-97072009000400006
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Schiff base ligands square-planar Knoevenagel
spellingShingle	Schiff base ligands square-planar Knoevenagel RAMAN,N JOSEPH,J SAKTHIVEL,A JEYAMURUGAN,R SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL SCHIFF BASE COPPER(II) COMPLEXES
description	Five novel copper(II) complexes have been synthesized using Schiff base ligands, synthesized by the condensation reaction of anthranilic acid and Knoevenagel β-ketoanilide condensates (obtained by the condensation of acetoacetanilide and substituted benzaldehydes). The ligands and copper(II) complexes have been characterized on the basis of Microanalytical, Mass, UV-Vis., IR, 'H NMR, ESR, XRD and CV spectral studies, as well as magnetic susceptibility and conductivity data. On the basis of spectral studies, a square-planar geometry has been proposed for the copper(II) complexes. From the XRD data, the CuL-1 complex has the crystallite size of 50 nm respectively. The in vitro antimicrobial activity of the compounds is tested against the bacteria Escherichia coli, Salmonella typhi, Staphylococcus aureus, Klebsiella pneumoniae and Pseudonomas aeruginosa and fungi Aspergillus niger, Rhizopus stolonifer, Aspergillus flavus, Rhizoctonia bataicola and Candida albicans by well diffusion method. The complexes show stronger antimicrobial activity than the free ligands. They represent a novel class of metal-based antimicrobial agents which provide opportunities for a large number of synthetic variations for modulation of the activities.
author	RAMAN,N JOSEPH,J SAKTHIVEL,A JEYAMURUGAN,R
author_facet	RAMAN,N JOSEPH,J SAKTHIVEL,A JEYAMURUGAN,R
author_sort	RAMAN,N
title	SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL SCHIFF BASE COPPER(II) COMPLEXES
title_short	SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL SCHIFF BASE COPPER(II) COMPLEXES
title_full	SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL SCHIFF BASE COPPER(II) COMPLEXES
title_fullStr	SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL SCHIFF BASE COPPER(II) COMPLEXES
title_full_unstemmed	SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL SCHIFF BASE COPPER(II) COMPLEXES
title_sort	synthesis, structural characterization and antimicrobial studies of novel schiff base copper(ii) complexes
publisher	Sociedad Chilena de Química
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400006
work_keys_str_mv	AT ramann synthesisstructuralcharacterizationandantimicrobialstudiesofnovelschiffbasecopperiicomplexes AT josephj synthesisstructuralcharacterizationandantimicrobialstudiesofnovelschiffbasecopperiicomplexes AT sakthivela synthesisstructuralcharacterizationandantimicrobialstudiesofnovelschiffbasecopperiicomplexes AT jeyamuruganr synthesisstructuralcharacterizationandantimicrobialstudiesofnovelschiffbasecopperiicomplexes
_version_	1718445411510779904

SYNTHESIS, STRUCTURAL CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL SCHIFF BASE COPPER(II) COMPLEXES

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