SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL ACTIVITY OF NEW STEROIDAL CHOLEST-5-EN-7-ONE DERIVATIVES FUSED WITH SUBSTITUTED PYRAZOLINE RING
The reaction of cholest-5-en-7-one (1), its 3β-acetoxy (2) and 3β-chloro (3) analogues with thiosemicarbazide in sodium ethoxide affords 2'-thiocarbamoyl-cholest [5,7-cd] pyrazoline (4), 2'-thiocarbamoyl-3β-acetoxycholest [5,7-cd] pyrazoline (5), and 2'-thio...
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| Autores principales: | , , |
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| Lenguaje: | English |
| Publicado: |
Sociedad Chilena de Química
2009
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| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400010 |
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| Sumario: | The reaction of cholest-5-en-7-one (1), its 3β-acetoxy (2) and 3β-chloro (3) analogues with thiosemicarbazide in sodium ethoxide affords 2'-thiocarbamoyl-cholest [5,7-cd] pyrazoline (4), 2'-thiocarbamoyl-3β-acetoxycholest [5,7-cd] pyrazoline (5), and 2'-thiocarbamoyl-3β-chloro cholest [5,7-cd] pyrazoline (6), respectively. The structures of the newly synthesized compounds have been established on the basis of physical, analytical and spectral data. Their antibacterial activities were tested in vitro by disk diffusion assay against Gram-positive and Gram-negative bacterial strains of bacteria. |
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